DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and Ncam1

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	272	Identity:	59/272 - (21%)
Similarity:	105/272 - (38%)	Gaps:	45/272 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LEPDQKSILTDNDWKKLWMRG---GINGDSKLDNNLDSSDSPMFEDSELMAH------------N 86
            |:.|.:.|:..|::  |.:||   ...|..:.:..:.:.....|:|.:::.:            |
Mouse   160 LKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVN 222

  Fly    87 TTVQLGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWHILSSGAQLYTNDERFAILHTPGSNMWTL 151
            .|..||.:..|||...|.....::|              :...:...|:|.....|....:...|
Mouse   223 ATANLGQSVTLVCDADGFPEPTMSW--------------TKDGEPIENEEEDDEKHIFSDDSSEL 273

  Fly   152 QIKFVQRRDHGMYECQVSTPTGIISHFVNLQVVVPEAFILGSGELHVDMGSTINLVCIIEKSPTP 216
            .|:.|.:.|...|.|......|.....::|:|...........:..:::...:.|.|  |.|..|
Mouse   274 TIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMELEEQVTLTC--EASGDP 336

  Fly   217 PQYVYWQKNDRLINYVDS---RRDITIETTPG---PRTQSR---LIIREPQVTDSGNYTCSASNT 272
            ...:.|:.:.|.|:..:.   .|....||..|   .|:.:|   |.::..|.||:|.|.|:||||
Mouse   337 IPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 401

  Fly   273 ---EPASIYVFV 281
               :..|:|:.|
Mouse   402 IGQDSQSMYLEV 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	20/96 (21%)
		Ig_3	193..271	CDD:404760	22/86 (26%)
		Ig strand B	204..208	CDD:409353	1/3 (33%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	2/6 (33%)
		Ig strand F	264..269	CDD:409353	2/4 (50%)
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	8/31 (26%)
		Ig3_NCAM-1_like	211..308	CDD:143207	21/110 (19%)
		Ig_NCAM-1	307..413	CDD:143277	27/107 (25%)
		Ig_3	417..494	CDD:372822
		FN3	509..606	CDD:238020
		fn3	649..731	CDD:365830
		PHA03247	<905..1140	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810