DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr12 and Dscam

DIOPT Version :9

Sequence 1:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	221	Identity:	58/221 - (26%)
Similarity:	86/221 - (38%)	Gaps:	42/221 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LGGTAFLVCKVSGVDRVGVNWNQISWIRRRDWHILSSGAQLYTNDERFAILHTPGSNMWTLQIKF 155
            :|....|.|.|:|.:.     .::||.|..:  ||:.|..          :...|.|...|.:..
Mouse   327 VGSQVSLSCSVTGNED-----QELSWYRNGE--ILNPGKN----------VRITGLNHANLIMDH 374

  Fly   156 VQRRDHGMYECQVSTPTGIISHFVNLQVVVPEA---FILGSGELHVDMGSTINLVCIIEKSPTPP 217
            :.:.|.|.|:|.|.........:|  |||:.:.   .|....|..|.....::|||.::.:|.|.
Mouse   375 MVKSDGGAYQCFVRKDKLSAQDYV--QVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPT 437

  Fly   218 QYVYWQKNDRLINYVDSRRDITIETTPGPRTQSRLIIREPQVTDSGNYTCSASNTE--------- 273
              |.|..:|..|......|...:.|:.| ...|.|.|...||.|.|.|.|:|:|:.
Mouse   438 --VTWTLDDDPILKGSGHRISQMITSEG-NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI 499

  Fly   274 ----PASIYVFVSKGDNMAAISRRKT 295
                ||||...    .|:.||:.|.|
Mouse   500 NVRGPASIRPM----KNITAIAGRDT 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr12	NP_652462.3	IG	86..183	CDD:214652	20/91 (22%)
		Ig_3	193..271	CDD:404760	24/77 (31%)
		Ig strand B	204..208	CDD:409353	1/3 (33%)
		Ig strand C	219..223	CDD:409353	1/3 (33%)
		Ig strand E	250..254	CDD:409353	2/3 (67%)
		Ig strand F	264..269	CDD:409353	2/4 (50%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652	20/91 (22%)
		Ig_3	410..488	CDD:372822	25/80 (31%)
		IGc2	518..575	CDD:197706	2/4 (50%)
		Ig	596..686	CDD:386229
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900