DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32354 and RECK

DIOPT Version :9

Sequence 1:	NP_729380.1	Gene:	CG32354 / 50302	FlyBaseID:	FBgn0052354	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_066934.1	Gene:	RECK / 8434	HGNCID:	11345	Length:	971	Species:	Homo sapiens

Alignment Length:	753	Identity:	157/753 - (20%)
Similarity:	233/753 - (30%)	Gaps:	284/753 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PSLGL--------SFGGTKSQRQLFGALLAMFTLAAFASTTSGAVTD-----SPIKI-------- 85
            ||.||        |...|.:.|:|...|.:|    ::.:|.|....|     :|:::
Human   281 PSTGLDGAKLHCCSKANTSTCRELCTKLYSM----SWGNTQSWQEFDRFCEYNPVEVSMLTCLAD 341

  Fly    86 IRLPAQ--------------APVIRYRSADA-----APNSL-----------LINYR----QDAR 116
            :|.|.|              .|...:||.:|     |.|.:           .||..    :..:
Human   342 VREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQ 406

  Fly   117 PELSSTL---MQAPGAAAAALESLLREETEQQQLSQMGRRNR--ASNTGTGNCP--------RSC 168
            ||:...:   :|.....:.:..|::.:....:.|.:.|.:|:  ..:|....|.        ::|
Human   407 PEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNC 471

  Fly   169 PP------SITVG--AEPV---CGSDGLIYANICELRKKTCSRSGVSLIKDVRDGCERSKGSD-- 220
            .|      ..|:|  .|.|   |..:......:||:.:|.|......|......||:..:.||
Human   472 IPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFI 536

  Fly   221 -----------------CKHRCSTEKDPVCGTDGRTYLNRCM----LRVQ-SCRVGLAAVKLSHV 263
                             |...||      ||..|  .|..||    :.:| ||.||  ..:.||
Human   537 VRQGTLIQVPSSAGEVGCYKICS------CGQSG--LLENCMEMHCIDLQKSCIVG--GKRKSH- 590

  Fly   264 GPCSNTSAVRESCPVDCNSAPKDGPVCSSDGNVYNSTCEMKLKTCGQGVVKTSRKHCQSTRMCRE 328
                     ..|..:|||       |||                |..|.:..|.:.|.|.....:
Human   591 ---------GTSFSIDCN-------VCS----------------CFAGNLVCSTRLCLSEHSSED 623

  Fly   329 ----------SCWRVARPTCGSDGRLYASPCKMRSSNCGKHVFEVPLSYCMSQERHGASDAC-PT 382
                      :|.....|.||.:||.|.|.|..|......|.||  ...|||:      |.| |.
Human   624 DRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFE--FGSCMSK------DPCNPN 680

  Fly   383 ECPKSDTDSSSQYVCGSDGNIYSSLCELKMLNCGPQRKSIQKVSMDKCKNRLTRCKQLPPCKDFN 447
            .|.|:........||         |.......|          |..:|..|...|.|:
Human   681 PCQKNQRCIPKPQVC---------LTTFDKFGC----------SQYECVPRQLACDQV------- 719

  Fly   448 SLFGSIFSSKRNDKLCGTDAKTYNNECELAHATCLRGVNLAHIGPCTDLNSPTKDCGDACTRADL 512
                       .|.:|.||...:||.|.|..    ||.:|::.|||......|
Human   720 -----------QDPVCDTDHMEHNNLCTLYQ----RGKSLSYKGPCQPFCRAT------------ 757

  Fly   513 EQQPVCGSDGNTFASMC-EFKRRTC-----DLRVVPV-----SLKNCA-------LTADCESDCD 559
              :||||.:|.|::|:| .:..|..     |.:.|.|     |:..||       |.|.|:   .
Human   758 --EPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCK---P 817

  Fly   560 AQPPSFVC-------------------GSDNN---------LYKSECHMRKENCGKH-------- 588
            ..||...|                   ....|         |.|...|:....|...
Human   818 IIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESE 882

  Fly   589 --VFVVPLKRCLAAFQLKGCARICPREFEPVCGSDNKT 624
              :.::|:.....|.|::.|.:.. .:.|.:..||:.|
Human   883 IVILIIPVDHYPKALQIEACNKEA-EKIESLINSDSPT 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:294071	12/55 (22%)
		KAZAL	220..266	CDD:197624	17/69 (25%)
		KAZAL_FS	326..>359	CDD:294071	10/42 (24%)
		KAZAL	380..430	CDD:197624	9/50 (18%)
		KAZAL	452..493	CDD:197624	12/40 (30%)
		KAZAL	502..>536	CDD:197624	9/34 (26%)
		KAZAL_FS	553..597	CDD:294071	10/81 (12%)
		KAZAL	606..650	CDD:197624	5/19 (26%)
RECK	NP_066934.1	OATP	<633..>658	CDD:281175	9/24 (38%)
RECK	NP_066934.1	Amnionless	<802..>886	CDD:291494	13/86 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900