Protein Alignment CG32354 and RECK

DIOPT Version :10

• Sequence 1: NP_729380.1
• Gene: CG32354 / 50302
• FlyBaseID: FBgn0052354
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_066934.1
• Gene: RECK / 8434
• HGNCID: 11345
• Length: 971
• Species: Homo sapiens
• Alignment Length: 753
• Identity: 157/753 - (20%)
• Similarity: 233/753 - (30%)
• Gaps: 284/753 - (37%)

  Fly    42 PSLGL--------SFGGTKSQRQLFGALLAMFTLAAFASTTSGAVTD-----SPIKI-------- 85
            ||.||        |...|.:.|:|...|.:|    ::.:|.|....|     :|:::
Human   281 PSTGLDGAKLHCCSKANTSTCRELCTKLYSM----SWGNTQSWQEFDRFCEYNPVEVSMLTCLAD 341

  Fly    86 IRLPAQ--------------APVIRYRSADA-----APNSL-----------LINYR----QDAR 116
            :|.|.|              .|...:||.:|     |.|.:           .||..    :..:
Human   342 VREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQ 406

  Fly   117 PELSSTL---MQAPGAAAAALESLLREETEQQQLSQMGRRNR--ASNTGTGNCP--------RSC 168
            ||:...:   :|.....:.:..|::.:....:.|.:.|.:|:  ..:|....|.        ::|
Human   407 PEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNC 471

  Fly   169 PP------SITVG--AEPV---CGSDGLIYANICELRKKTCSRSGVSLIKDVRDGCERSKGSD-- 220
            .|      ..|:|  .|.|   |..:......:||:.:|.|......|......||:..:.||
Human   472 IPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFI 536

  Fly   221 -----------------CKHRCSTEKDPVCGTDGRTYLNRCM----LRVQ-SCRVGLAAVKLSHV 263
                             |...||      ||..|  .|..||    :.:| ||.||  ..:.||
Human   537 VRQGTLIQVPSSAGEVGCYKICS------CGQSG--LLENCMEMHCIDLQKSCIVG--GKRKSH- 590

  Fly   264 GPCSNTSAVRESCPVDCNSAPKDGPVCSSDGNVYNSTCEMKLKTCGQGVVKTSRKHCQSTRMCRE 328
                     ..|..:|||       |||                |..|.:..|.:.|.|.....:
Human   591 ---------GTSFSIDCN-------VCS----------------CFAGNLVCSTRLCLSEHSSED 623

  Fly   329 ----------SCWRVARPTCGSDGRLYASPCKMRSSNCGKHVFEVPLSYCMSQERHGASDAC-PT 382
                      :|.....|.||.:||.|.|.|..|......|.||  ...|||:      |.| |.
Human   624 DRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFE--FGSCMSK------DPCNPN 680

  Fly   383 ECPKSDTDSSSQYVCGSDGNIYSSLCELKMLNCGPQRKSIQKVSMDKCKNRLTRCKQLPPCKDFN 447
            .|.|:........||         |.......|          |..:|..|...|.|:
Human   681 PCQKNQRCIPKPQVC---------LTTFDKFGC----------SQYECVPRQLACDQV------- 719

  Fly   448 SLFGSIFSSKRNDKLCGTDAKTYNNECELAHATCLRGVNLAHIGPCTDLNSPTKDCGDACTRADL 512
                       .|.:|.||...:||.|.|..    ||.:|::.|||......|
Human   720 -----------QDPVCDTDHMEHNNLCTLYQ----RGKSLSYKGPCQPFCRAT------------ 757

  Fly   513 EQQPVCGSDGNTFASMC-EFKRRTC-----DLRVVPV-----SLKNCA-------LTADCESDCD 559
              :||||.:|.|::|:| .:..|..     |.:.|.|     |:..||       |.|.|:   .
Human   758 --EPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCK---P 817

  Fly   560 AQPPSFVC-------------------GSDNN---------LYKSECHMRKENCGKH-------- 588
            ..||...|                   ....|         |.|...|:....|...
Human   818 IIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESE 882

  Fly   589 --VFVVPLKRCLAAFQLKGCARICPREFEPVCGSDNKT 624
              :.::|:.....|.|::.|.:.. .:.|.:..||:.|
Human   883 IVILIIPVDHYPKALQIEACNKEA-EKIESLINSDSPT 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:412159	12/55 (22%)
		KAZAL	220..266	CDD:197624	17/69 (25%)
		KAZAL_FS	326..>359	CDD:412159	10/42 (24%)
		KAZAL	380..430	CDD:197624	9/50 (18%)
		KAZAL	452..493	CDD:197624	12/40 (30%)
		KAZAL	502..>536	CDD:197624	9/34 (26%)
		KAZAL_FS	553..597	CDD:412159	10/81 (12%)
		KAZAL	606..650	CDD:197624	5/19 (26%)
RECK	NP_066934.1	MFS	<633..699	CDD:475125	24/82 (29%)
		Amnionless	<802..>886	CDD:464340	13/86 (15%)