DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32354 and Spink5

DIOPT Version :9

Sequence 1:	NP_729380.1	Gene:	CG32354 / 50302	FlyBaseID:	FBgn0052354	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001074649.1	Gene:	Spink5 / 72432	MGIID:	1919682	Length:	1017	Species:	Mus musculus

Alignment Length:	848	Identity:	169/848 - (19%)
Similarity:	255/848 - (30%)	Gaps:	374/848 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 LMQAPGAAAAALESLLREETEQQQLSQMGRRNRASNTGTGNCPRSCPPSITVGAEPVCGSDGLIY 187
            |.:|...|....||.:|.:.|::...:.  .|:..| |...|.|.        ::|:.|.||.::
Mouse   203 LKEAKENATRNRESRIRRDAEKELCKEF--ENQVRN-GRLFCTRE--------SDPIRGPDGKMH 256

  Fly   188 ANICEL------RKKTCSRSGVSLIKDVRDGCERSKG--------SDCKHR-------CSTEKDP 231
            .|.|.|      |:.|..:....  |:.:|..||:|.        |:.:.|       |:.|.||
Mouse   257 GNKCALCAEIFMRQFTEEKGKAE--KNQKDAEERAKAKMEIQKRCSEFQDRARNGTLFCTRENDP 319

  Fly   232 VCGTDGRTYLNRCMLRVQSCRVGL---AAVKLSHVGP---------------CSNTSAVRESCPV 278
            :.|.||:|:.|.|.:    |:...   |..|.:..|.               |......|::..:
Mouse   320 IRGLDGKTHGNLCSM----CQAFFKTEAEEKKAEAGSRNRRGSEESETYAKLCDEYRKARKNGQL 380

  Fly   279 DC--NSAPKDGPVCSSDGNVYNSTCEMKLKTCGQGVVKTSRKHCQSTR-----MCRE-------- 328
            .|  .:||..||    ||.::.:||.|    |....::..:...:..|     ||.|
Mouse   381 YCTRENAPIRGP----DGKIHGNTCSM----CQAFFIQEDKARAKVKREAAKEMCSEFRNQARNG 437

  Fly   329 --SCWRVARPTCGSDGRLYASPCKMRSS------------------NCGKHVFEVPLSYCM---S 370
              .|.|...|..|.||:.:::.|.|.:|                  :.||...|.....|.   :
Mouse   438 MLMCTRENDPVVGPDGKRHSNKCAMCASVFLLEEEEKKKDDKTEKVDAGKAKKEAVQELCRKYHT 502

  Fly   371 QERHGASDACPTECPKSDTDSSSQYVCGSDGNIYSSLC---------ELKMLNCGPQRKSIQKVS 426
            |.|:|     |..|.:.:..     :.|.||.:|.:.|         |.|....|.:.|..::|.
Mouse   503 QLRNG-----PLRCTRRNNP-----IEGLDGKMYKNACFMCWAFFQQEAKKSGAGFRPKVKREVK 557

  Fly   427 MDKCKNRLTRCKQLPPCKDFNSLFGSIFSSKRNDKLCGTDAKTYNNECELAHA------------ 479
            :| |...|...|:           |.||.::.||.:.|.|.||:.|:|.:..|
Mouse   558 VD-CSEYLALSKR-----------GEIFCTRENDPVRGPDGKTHGNKCAMCKAVFKKENEERKRK 610

  Fly   480 ------------------------------------TC------LRGVNLAHI-GPC-------- 493
                                                :|      :|||:..|. ..|
Mouse   611 EGENQRITSGESSSGGNPKAKDECAQYRESMKHGQLSCTRESDPVRGVDGEHYNNKCVMCKELLQ 675

  Fly   494 -----TDLNSPTKDCGDA---------------------CTRADLEQQPVCGSDGNTFASMC--- 529
                 |:.||.::..|..                     |||   |..|..|.||....:.|
Mouse   676 KEMEETNKNSASRSNGTGSATGKDVCDQFRSQMKNGKLLCTR---ESDPTRGPDGAMHGNKCAMC 737

  Fly   530 ----------------EFKRRT----------C--------DLRVV------PV-------SLKN 547
                            |.||.|          |        |.|::      ||       .:..
Mouse   738 KERLEKEAAEKKKKEDEEKRNTETNKSDKEDKCHEYRSMQLDGRLICTRENDPVRDADGKMHVNK 802

  Fly   548 CAL-----------------------TADCESDC--------DAQP-------PSF--------- 565
            ||:                       |.:.:..|        ||:|       ||.
Mouse   803 CAMCQMMFEREANERKMREENSRSQPTNEAKDQCGEVHNSVEDAKPRPARSSLPSIRGISKDECS 867

  Fly   566 -------------------VCGSDNNLYKSECHMRKENCGKHVFVVPLKR--------------- 596
                               |.|:|...|:::|||    |...:....:||
Mouse   868 EFQNLMKNEKLTCPETDDPVRGADGTFYQNKCHM----CRDVLKNEAMKRSGLQEKSSDIRSTKE 928

  Fly   597 --------------CLAAFQLKGCARICPREFEPVCGSDNKTYLNDCFLEIENCRANQTVNVNYY 647
                          |.....|.....:||:...||||.|.:||.|.|.|..||........::..
Mouse   929 GDPEFSSSSRDSDMCKNYRILPRMGYLCPKNLNPVCGDDGQTYSNPCMLCHENLMRQTNTRIHKQ 993

  Fly   648 GAC 650
            |||
Mouse   994 GAC 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:294071	11/42 (26%)
		KAZAL	220..266	CDD:197624	15/70 (21%)
		KAZAL_FS	326..>359	CDD:294071	12/60 (20%)
		KAZAL	380..430	CDD:197624	13/58 (22%)
		KAZAL	452..493	CDD:197624	16/95 (17%)
		KAZAL	502..>536	CDD:197624	14/83 (17%)
		KAZAL_FS	553..597	CDD:294071	16/115 (14%)
		KAZAL	606..650	CDD:197624	15/43 (35%)
Spink5	NP_001074649.1	KAZAL_PSTI	108..152	CDD:238648
		KAZAL_FS	176..>200	CDD:381802
		KAZAL	240..275	CDD:197624	11/42 (26%)
		KAZAL	312..351	CDD:197624	13/42 (31%)
		KAZAL_FS	441..>464	CDD:381802	8/22 (36%)
		KAZAL	573..613	CDD:197624	10/39 (26%)
		KAZAL_FS	648..>672	CDD:381802	6/23 (26%)
		KAZAL_FS	715..>740	CDD:381802	9/27 (33%)
		KAZAL_FS	783..821	CDD:381802	4/37 (11%)
		KAZAL_PSTI	953..996	CDD:238648	15/42 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5238
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860