DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32354 and Reck

DIOPT Version :9

Sequence 1:	NP_729380.1	Gene:	CG32354 / 50302	FlyBaseID:	FBgn0052354	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_057887.2	Gene:	Reck / 53614	MGIID:	1855698	Length:	971	Species:	Mus musculus

Alignment Length:	792	Identity:	156/792 - (19%)
Similarity:	246/792 - (31%)	Gaps:	305/792 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHHKQHLH----LHLQPPAPNATQTQAHGLGQTPSQIAR--CSHNHSPSLGLSFGGTKSQRQLFG 59
            :...|.:|    :| .||:......:.|...:..:...|  |:..:|    :|:|.|:|.:: |.
Mouse   265 LESSQSVHPGVTVH-PPPSTGLDGAKLHCCSKANTSTCRELCTKLYS----MSWGNTQSWQE-FD 323

  Fly    60 AL-------LAMFTLAA--------------------------FASTTS----GAVTDSPIKI-- 85
            .:       ::|.|..|                          |.|.|:    ||::|  :|:
Mouse   324 RICEYNPVEVSMLTCLADVREPCQLGCTNLTYCTNFNNRPTELFRSCTAQSDQGAMSD--MKLWE 386

  Fly    86 ---IRLP-AQAPVIRYRSADAAPNSLLINYRQDARPELSSTL---MQAPGAAAAALESLLREETE 143
               |::| ...||:..::               .:||:...:   :|.....:.:..|::.:...
Mouse   387 KGSIKMPFISIPVLDIKT---------------CQPEMWKAVACSLQIKPCHSKSRGSIICKSDC 436

  Fly   144 QQQLSQMGRRNR--ASNTGTGNCP--------RSCPP-----------SITVGAEPVCGSDGLIY 187
            .:.|.:.|.:|:  ..:|....|.        .||.|           :|.......|..:....
Mouse   437 VEILKKCGDQNKFPEEHTAESICEFLSPADDLESCIPLDTYLRPSALGNIIEEVTHPCNPNPCPA 501

  Fly   188 ANICELRKKTCSRSGVSLIKDVRDGCERSKGSD-------------------CKHRCSTEKDPVC 233
            ..:||:.:|.|..:...|......||:..:.||                   |...||      |
Mouse   502 NELCEVNRKGCPSADPCLPYSCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICS------C 560

  Fly   234 GTDGRTYLNRCM----LRVQ-SCRVGLAAVKLSHVGPCSNTSAVRESCPVDCNSAPKDGPVCSSD 293
            |..|  .|..||    :.:| ||.||  ..:.||          ..|..:|||       |||..
Mouse   561 GQSG--LLENCMEMHCIDLQKSCIVG--GKRKSH----------GTSFTIDCN-------VCSCF 604

  Fly   294 GNVYNSTCEMKLKTCGQGVVKTSRKHCQSTRMCRE----------------SCWRVARPTCGSDG 342
            ..  |..|                    |||:|..                :|.....|.|..:|
Mouse   605 AG--NLVC--------------------STRLCLSEHSSDDDRRTFTGLPCNCADQFVPVCAQNG 647

  Fly   343 RLYASPCKMRSSNCGKHVFEVPLSYCMSQERHGASDAC-PTECPKSDTDSSSQYVCGSDGNIYSS 406
            |.|.|.|..|......|.||  ...|:|:      :.| |..||||........||
Mouse   648 RTYPSACIARCVGLQDHQFE--FGPCISK------NPCNPNLCPKSQRCVPKPQVC--------- 695

  Fly   407 LCELKMLNCGPQRKSIQKVSMDKCKNRLTRCKQLPPCKDFNSLFGSIFSSKRNDKLCGTDAKTYN 471
            |.......|          |..:|..|...|.|                  ..|.:|.||...::
Mouse   696 LTTFDKFGC----------SQYECVPRQLTCDQ------------------ARDPVCDTDHMEHS 732

  Fly   472 NECELAHATCLRGVNLAHIGPCTDLNSPTKDCGDACTRADLEQQPVCGSDGNTFASMC-EFKRRT 535
            |.|.|..    ||.:|::.|||...          | ||   ::||||.:|.|::|:| .:..|.
Mouse   733 NLCTLYQ----RGKSLSYRGPCQPF----------C-RA---KEPVCGHNGETYSSVCAAYSDRV 779

  Fly   536 C-----DLRVVPVSLKNCALTADCES-DCDAQ---------PPSFVC----GSDNNLYKSE---- 577
            .     ..:.|.| |...:..|:|.: .|.:.         ||...|    |....|:..|
Mouse   780 AVDYYGPCQAVGV-LSEYSAVAECAAVKCPSLSAIGCKPIIPPGACCPLCAGMLRVLFDKEKLDT 843

  Fly   578 --------------------CHMRKENCGKH----------VFVVPLKRCLAAFQLKGCARICPR 612
                                .|:....|...          :.::|:.....|.|::.|.:.. .
Mouse   844 IAKVTSKKPITVVEILQKVRMHVSVPQCDVFGYLSIESEIVILIIPVDHYPKALQIEACNKEA-E 907

  Fly   613 EFEPVCGSDNKT 624
            :.|.:..||:.|
Mouse   908 KIESLINSDSPT 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:294071	10/55 (18%)
		KAZAL	220..266	CDD:197624	17/69 (25%)
		KAZAL_FS	326..>359	CDD:294071	10/48 (21%)
		KAZAL	380..430	CDD:197624	11/50 (22%)
		KAZAL	452..493	CDD:197624	11/40 (28%)
		KAZAL	502..>536	CDD:197624	12/34 (35%)
		KAZAL_FS	553..597	CDD:294071	11/91 (12%)
		KAZAL	606..650	CDD:197624	5/19 (26%)
Reck	NP_057887.2	5 X Knot repeats	37..338		15/78 (19%)
Reck	NP_057887.2	Amnionless	<802..>867	CDD:291494	9/64 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900