DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32354 and AGRN

DIOPT Version :9

Sequence 1:	NP_729380.1	Gene:	CG32354 / 50302	FlyBaseID:	FBgn0052354	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001292204.1	Gene:	AGRN / 375790	HGNCID:	329	Length:	2068	Species:	Homo sapiens

Alignment Length:	792	Identity:	189/792 - (23%)
Similarity:	264/792 - (33%)	Gaps:	305/792 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 LLREETEQQQLSQM------GRRNRASNTGT---GNCPRS---------CPPSITVGAE-PVCGS 182
            |.|.:..||:..::      |.|:..||...   ..|.||         ||.:.....| .||||
Human   223 LQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGS 287

  Fly   183 DGLIYANICELRKKTCSRSGVSLIKDVRDGCERSKGS------DCK--------------HRCST 227
            ||..|...|:|.::.|:|. .::.|.....|:..:|:      .|:              ..|..
Human   288 DGADYPGECQLLRRACARQ-ENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPA 351

  Fly   228 EKDPVCGTDGRTYLNRCMLRVQSCRVGLAAVKLSHVGPCSNTSAVRESCPVDC---------NSA 283
            .:.||||.||.||.|.|::.......||...|: ..|.|..    |:.||..|         ...
Human   352 RQAPVCGDDGVTYENDCVMGRSGAARGLLLQKV-RSGQCQG----RDQCPEPCRFNAVCLSRRGR 411

  Fly   284 PK--------DG---PVCSSDGNVYNSTCEMKLKTCGQ--------------------GV----- 312
            |:        ||   |||:.||..|:|.|..:...|.|                    ||
Human   412 PRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFG 476

  Fly   313 ----VKTSRKHCQSTRMCRESCWRVARPTCGSDGRLYASPCKMRSSNC--GKHVFEV----PLSY 367
                ||..:..|:    |.::|..:..|.|||||..|.|.|::.::.|  |:.: :|    |...
Human   477 ATCAVKNGQAACE----CLQACSSLYDPVCGSDGVTYGSACELEATACTLGREI-QVARKGPCDR 536

  Fly   368 CMSQERHGA-------SDACPTECPKSDTDSSSQYVCGSDGNIYSSLCELKMLNCGPQRKSIQKV 425
            | .|.|.||       ...||:||.     :.:|.||||||:.|.|.|.|.:..|..| .|:...
Human   537 C-GQCRFGALCEAETGRCVCPSECV-----ALAQPVCGSDGHTYPSECMLHVHACTHQ-ISLHVA 594

  Fly   426 SMDKCKNRLTRCKQLPPCKDFNSLFGSIFSSKR----------NDKLCGTDAKTYNNECELAHAT 480
            |...|:.          |.|....||::.|:.:          ...:||:|..||.:.|||..|.
Human   595 SAGPCET----------CGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAA 649

  Fly   481 CLRGVNL--AHIGPCTDLNSPTKDCGDACTRA----DLEQQ------------------------ 515
            ||:...:  |..|||..     .:||...:.:    |.||:
Human   650 CLQQTQIEEARAGPCEQ-----AECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSC 709

  Fly   516 ------PVCGSDGNTFASMCEFKRRTCDLR------------------VVPVSLKNCALT----- 551
                  |||||||.|:::.||.|:..|:.:                  :.||:..:||.|
Human   710 QSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCC 774

  Fly   552 ------------ADCESDCDAQP------------------------------PSF--------- 565
                        |.|.|.|...|                              |.|
Human   775 QDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTD 839

  Fly   566 ------VCGSD-NNLYKSECHMRKENC-------GKHVFVVPLKRCLAAFQLKGC---------- 606
                  .|..| ....:.:|......|       |......|..|.|..   .||
Human   840 GRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGP---AGCEADASAPATC 901

  Fly   607 --------AR----------ICPREFEP------VCGSDNKTYLNDCFLEIENCRANQTVNVNYY 647
                    ||          :||....|      |||||..||.|:|.|:...||....:::...
Human   902 AEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSL 966

  Fly   648 GACGRPEAPSTN 659
            |.|....||||:
Human   967 GPCQEAVAPSTH 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:294071	16/46 (35%)
		KAZAL	220..266	CDD:197624	16/59 (27%)
		KAZAL_FS	326..>359	CDD:294071	13/34 (38%)
		KAZAL	380..430	CDD:197624	19/49 (39%)
		KAZAL	452..493	CDD:197624	14/52 (27%)
		KAZAL	502..>536	CDD:197624	16/67 (24%)
		KAZAL_FS	553..597	CDD:294071	12/96 (13%)
		KAZAL	606..650	CDD:197624	19/77 (25%)
AGRN	NP_001292204.1	NtA	44..146	CDD:308653
		KAZAL	196..242	CDD:197624	4/18 (22%)
		KAZAL	272..317	CDD:197624	15/45 (33%)
		KAZAL_FS	349..389	CDD:320757	15/40 (38%)
		KAZAL_FS	421..461	CDD:238052	12/39 (31%)
		KAZAL	489..534	CDD:197624	14/49 (29%)
		KAZAL	554..599	CDD:197624	19/50 (38%)
		KAZAL	619..664	CDD:197624	13/44 (30%)
		KAZAL	704..750	CDD:197624	12/45 (27%)
		Laminin_EGF	793..835	CDD:278482	4/41 (10%)
		Laminin_EGF	847..>883	CDD:278482	6/35 (17%)
		KAZAL	922..969	CDD:197624	16/46 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	995..1096
		SEA	1130..1254	CDD:214554
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1277..1334
		EGF	1333..1363	CDD:306513
		Laminin_G_1	1400..1531	CDD:278483
		EGF_CA	1555..1585	CDD:238011
		Laminin_G_1	1668..1803	CDD:278483
		EGF_CA	1825..1857	CDD:238011
		Laminin_G_1	1921..2051	CDD:278483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7617
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860