DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32354 and TMEFF2

DIOPT Version :9

Sequence 1:	NP_729380.1	Gene:	CG32354 / 50302	FlyBaseID:	FBgn0052354	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_057276.2	Gene:	TMEFF2 / 23671	HGNCID:	11867	Length:	374	Species:	Homo sapiens

Alignment Length:	328	Identity:	67/328 - (20%)
Similarity:	112/328 - (34%)	Gaps:	112/328 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 CKHRCSTEKDPVCGTDGRTYLNRCMLRVQSCRVGLAAVKLSHVGPCSNTSAVRE-SCPVDCNSAP 284
            |:.:|:.:..||||::|.:|.|.|.||..:|:            ..|....|.| ||..|..|..
Human    91 CQFKCNNDYVPVCGSNGESYQNECYLRQAACK------------QQSEILVVSEGSCATDAGSGS 143

  Fly   285 KDGPVCSSDGNVYNSTCEMKLKTCGQGVVKTSRKHCQSTRMCRESCWRVARPTCGSDGRLYASPC 349
            .||                    ..:|..:||:|...:..:|:
Human   144 GDG--------------------VHEGSGETSQKETSTCDICQ---------------------- 166

  Fly   350 KMRSSNCGKHVFEVPLSYCMSQERHGASDACPTECPKSDTDSSSQYVCGSDGNIYSSLCELKMLN 414
              ..:.|.:...:|   :|:          |..:|.:::.:.    :|.|||..|.:.|::|..:
Human   167 --FGAECDEDAEDV---WCV----------CNIDCSQTNFNP----LCASDGKSYDNACQIKEAS 212

  Fly   415 CGPQRKSIQKVSMDKCKNRLTRCKQLP----PCKDFNSLFGSIFSSKRNDKL-CGTDAKTYNNEC 474
            |..|.| |:.:|:.:|::..|...:..    ...|:......:..|.|...: |   .:.||..|
Human   213 CQKQEK-IEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPC---PEHYNGFC 273

  Fly   475 ELAHATCLRGVNLAHIGPCTDLNSPTKDCGDACTRADLEQQPVCGSDGNTFASMCEFKRRTCDLR 539
              .|..|...:|:                          |:|.|..|.......|| |:....|.
Human   274 --MHGKCEHSINM--------------------------QEPSCRCDAGYTGQHCE-KKDYSVLY 309

  Fly   540 VVP 542
            |||
Human   310 VVP 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:294071
		KAZAL	220..266	CDD:197624	13/44 (30%)
		KAZAL_FS	326..>359	CDD:294071	2/32 (6%)
		KAZAL	380..430	CDD:197624	14/49 (29%)
		KAZAL	452..493	CDD:197624	9/41 (22%)
		KAZAL	502..>536	CDD:197624	7/33 (21%)
		KAZAL_FS	553..597	CDD:294071
		KAZAL	606..650	CDD:197624
TMEFF2	NP_057276.2	KAZAL_FS	95..135	CDD:238052	15/51 (29%)
		KAZAL	181..227	CDD:197624	14/60 (23%)
		PHA02887	<236..301	CDD:165214	14/95 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810