DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32354 and F29G6.1

DIOPT Version :9

Sequence 1:	NP_729380.1	Gene:	CG32354 / 50302	FlyBaseID:	FBgn0052354	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_509920.3	Gene:	F29G6.1 / 181339	WormBaseID:	WBGene00009257	Length:	1189	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	146/754 - (19%)
Similarity:	252/754 - (33%)	Gaps:	243/754 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TKSQRQLFGALLAMFTLAAFASTTSGAVTDSPIKIIRLPAQAPVIRYRSADAAPNSLLINYRQDA 115
            |...:|...:....|.::||.            |:::.....|         :|:|.::
Worm   474 TSQLKQTVASEKTTFIVSAFE------------KVLKSTTSTP---------SPSSTIV------ 511

  Fly   116 RPELSSTLMQAPGAAAAAL-----ESLLREETEQQQLSQMGRRNRASNTGTGNCPR-SCPPSITV 174
                 :|.::.|....:.|     :|:|..|.|         .....:....:||: :||    .
Worm   512 -----TTTIKVPTVTFSTLPDPTTKSILEIEIE---------TTTPLDVAFFDCPKPNCP----T 558

  Fly   175 GAEPVCGSDGLIYANICELRKKTC--SRSGVSLIKDVRDGCERSKGSDCKHRCSTEKDPVCGTDG 237
            ..:|||.|.|.::.|:||.....|  :..|..:.....:.|...:.  |:..|:.:|.|:|.:|.
Worm   559 DGQPVCDSAGNLHGNLCEFTYSRCIAASKGHQIHIATEENCISKEA--CQMPCTDDKHPICASDF 621

  Fly   238 RTYLNRCMLRVQSCRVGLAAVKLSHVGPCS-------------------------NTSAVRE--- 274
            .||.|.|..|.|.|..  :.:::...|.||                         :|.::.|
Worm   622 STYENLCQFRKQKCLD--SELEVLFKGKCSECLDSPCALPAENSPDESFVCLEDQSTKSLCEYQM 684

  Fly   275 -SC--------------------PVDCNSAPKDGPVCSSDGNVYNSTCEMKLKTC---------- 308
             ||                    ||:.....|..|||:..|..:.:.||:.::.|
Worm   685 LSCIFERGYGVNLTVQYIGVCCPPVESCDTEKPDPVCTDSGATFLTECELNIENCKLKKLDQPKL 749

  Fly   309 ---GQGVVK--------TSRKHCQ---------STRMCRESCWRVARPTCGSDGRLYASPCKMRS 353
               .||:.:        :|.::.|         :|..|...|.....|.||::|..:.:.|.::.
Worm   750 VVVSQGICEKDMLTDDFSSNRNFQKPNIEFKRENTFNCSMECDNSYDPLCGTNGVTFTNACSLQK 814

  Fly   354 SNCGKHVFEVPLSYCMSQERHGASDACPTECPKSDTDSSSQYVCGSDGNIYSSLCELKMLNCGPQ 418
            ..|......:.::|        ....|.|.||     |....||.|.|:.:.::|...:..|..:
Worm   815 EICESANSTIEVAY--------TGMCCDTNCP-----SDFSPVCDSKGSTHQNICHFGVKRCIAE 866

  Fly   419 RKSIQKVSMDKCK--NRLTRCKQLPPCKDFNSLFGSIFSSKRNDKLCGTDAKTYNNECELAHATC 481
            |.....:::||.:  |.:..|....|              |....:|.::.:...|||||....|
Worm   867 RTFGDVLTIDKFEVCNEVKECNNACP--------------KEYSPVCASNGQNIVNECELDKIRC 917

  Fly   482 LRGVNLAHIGPCTDLNSPTKDCGDACTR---ADLEQ-QPVCGSDGNTFASMCEFKRRTC-----D 537
            |...|:      |..:...||....|.|   .|:.. .|||.::|.|.|:||...:..|     :
Worm   918 LVENNV------TTGDKLVKDYDGECCRIENCDISVFSPVCDTEGVTHANMCLMDQNACIQMKKN 976

  Fly   538 LRVVPVSLKNCALTADCESD----CD--------------------------------------- 559
            .:.:.||.:.......|:.|    ||
Worm   977 KKTIQVSYQGQCCNQPCDEDKTPVCDGTITHPNICRFRIAQCEAERVNKTLSIAYSGECCLLPKG 1041

  Fly   560 -AQPPSFVCGSDNNLYKSECHMRKENC------GKHVFVVPLKRCLAAFQLKGCARICPREFEPV 617
             .:....||.|:...:.:.|..::..|      .|.:.:|....|.|...       ||:..:||
Worm  1042 ECESSGAVCDSEGQTHMNHCVYQQRRCMAQTISQKTLNIVHTGECCALAS-------CPKTGQPV 1099

  Fly   618 CGSDNKTYLNDCFLEIENC------RANQTVNVNYYGAC 650
            |.|..:|:.:.|......|      ..|.|:.::|.|.|
Worm  1100 CDSRGRTHDSLCHFHNSKCIFDKIHTQNTTLTLDYQGKC 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:294071	13/39 (33%)
		KAZAL	220..266	CDD:197624	14/45 (31%)
		KAZAL_FS	326..>359	CDD:294071	8/32 (25%)
		KAZAL	380..430	CDD:197624	13/49 (27%)
		KAZAL	452..493	CDD:197624	10/40 (25%)
		KAZAL	502..>536	CDD:197624	12/37 (32%)
		KAZAL_FS	553..597	CDD:294071	11/93 (12%)
		KAZAL	606..650	CDD:197624	13/49 (27%)
F29G6.1	NP_509920.3	KAZAL_FS	40..79	CDD:238052
		KAZAL_FS	133..>168	CDD:294071
		KAZAL	274..320	CDD:197624
		KAZAL	389..>424	CDD:197624
		KAZAL	550..599	CDD:197624	14/52 (27%)
		KAZAL	605..648	CDD:197624	14/44 (32%)
		KAZAL	786..832	CDD:197624	9/53 (17%)
		KAZAL	833..881	CDD:197624	14/52 (27%)
		KAZAL	886..937	CDD:197624	15/70 (21%)
		KAZAL	941..988	CDD:197624	12/46 (26%)
		KAZAL	1092..1138	CDD:197624	13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1283825at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_111109
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.710