Protein Alignment CG32354 and SPINK5

DIOPT Version :10

• Sequence 1: NP_729380.1
• Gene: CG32354 / 50302
• FlyBaseID: FBgn0052354
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_001121170.1
• Gene: SPINK5 / 11005
• HGNCID: 15464
• Length: 1094
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 146/773 - (18%)
• Similarity: 237/773 - (30%)
• Gaps: 314/773 - (40%)

  Fly   124 MQAP-----GAAAAALESLLREETEQQQLSQMGRRNRASNTGTGNCPRSCPP----------SIT 173
            :|.|     |...:..|...:.|.|:::..:...||:..:..|.:....|..          ..|
Human   388 IQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCT 452

  Fly   174 VGAEPVCGSDGLIYANIC-------------------ELRKKTCSRSGVSLIKD-VRDGCERSKG 218
            ...:|:.|.||.::.|.|                   |..|:.||.     .:| ||:|
Human   453 RENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSE-----FRDQVRNG------ 506

  Fly   219 SDCKHRCSTEKDPVCGTDGRTYLNRCML---------------RVQSCRVGLAAVKLSHVGPCSN 268
               ...|:.|.:||.|.||:.:.|:|.:               :.:..:|....||
Human   507 ---TLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVK--------- 559

  Fly   269 TSAVRESCP----------VDCNSAPKDGPVCSSDGNVYNSTCEM---------KLKTCGQGVVK 314
            ..||:|.|.          :.|..  ::.|:...||.::.:||.|         |.|...:...|
Human   560 REAVQELCSEYRHYVRNGRLPCTR--ENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAK 622

  Fly   315 TSR----KHCQSTRMCRES----CWRVARPTCGSDGRLYASPCKMRSSNCGKHVFEVPLSYCMSQ 371
            ..|    :.|...|...::    |.|...|..|.||:.:.:.|.|    | |.||:..     ::
Human   623 VKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAM----C-KAVFQKE-----NE 677

  Fly   372 ER-------------HGAS--------DACP----------TECPKSDTDSSSQYVCGSDGNIYS 405
            ||             ||:|        |.|.          ..|.:     .|..|..:||..|:
Human   678 ERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTR-----ESDPVRDADGKSYN 737

  Fly   406 ---SLCELKMLNCGPQRKSIQKVSMDKCKNRLTRCKQ-LPPCKDFNSLF--GSIFSSKRNDKLCG 464
               ::|:.|:     :|::.:|....:.::..|..:. ...|.:|.|..  |.:..::.:|.:.|
Human   738 NQCTMCKAKL-----EREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRG 797

  Fly   465 TDAKTYNNECEL-------------------------------------------------AHAT 480
            .|.||:.|:|.:                                                 ....
Human   798 PDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLI 862

  Fly   481 CLRGVN-------LAHIGPCTDLNS--------------------PTKDCGDACTRADLE----- 513
            |.|..|       ..||..|....|                    |:.:..|.|.:...|
Human   863 CTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAK 927

  Fly   514 -QQPVCGSDGNTFASMCEFKRRTC-DLRVVPVSLKNCALTADCESDCDAQPPSFVCGSDNNLYKS 576
             :||     |.:.||:.......| :.|..   ::|..|....|:|     |  |.|:|...|.:
Human   928 FRQP-----GRSLASVARMSTDECSEFRNY---IRNNELICPREND-----P--VHGADGKFYTN 977

  Fly   577 ECHMRKENCGKHVFVVPLKRCLAAFQLKGCAR--------------------------------- 608
            :|:|                |.|.|..:...|
Human   978 KCYM----------------CRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDY 1026

  Fly   609 --------ICPREFEPVCGSDNKTYLNDCFLEIENCRANQTVNVNYYGACGRPEAPST 658
                    :||::.:||||.|.:||.|.|.|..||.......::...|.|.....|.|
Human  1027 RVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGT 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:412159	11/65 (17%)
		KAZAL	220..266	CDD:197624	12/60 (20%)
		KAZAL_FS	326..>359	CDD:412159	9/36 (25%)
		KAZAL	380..430	CDD:197624	11/62 (18%)
		KAZAL	452..493	CDD:197624	12/96 (13%)
		KAZAL	502..>536	CDD:197624	8/39 (21%)
		KAZAL_FS	553..597	CDD:412159	9/43 (21%)
		KAZAL	606..650	CDD:197624	16/84 (19%)
SPINK5	NP_001121170.1	KAZAL_PSTI	107..151	CDD:238648
		KAZAL	175..>199	CDD:197624
		KAZAL	238..272	CDD:197624
		KAZAL_FS	310..346	CDD:412159
		KAZAL_FS	509..>533	CDD:412159	9/23 (39%)
		KAZAL	645..>673	CDD:197624	11/32 (34%)
		KAZAL	721..>749	CDD:197624	8/37 (22%)
		KAZAL	787..827	CDD:197624	7/39 (18%)
		KAZAL_FS	862..902	CDD:412159	7/39 (18%)
		KAZAL_PSTI	1032..1076	CDD:238648	15/43 (35%)