DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32354 and FST

DIOPT Version :9

Sequence 1:	NP_729380.1	Gene:	CG32354 / 50302	FlyBaseID:	FBgn0052354	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_005248457.1	Gene:	FST / 10468	HGNCID:	3971	Length:	357	Species:	Homo sapiens

Alignment Length:	372	Identity:	84/372 - (22%)
Similarity:	125/372 - (33%)	Gaps:	143/372 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 ELRKKTCSRSG-VSLI---KDVRD--------------GCERSKGSDCKHRCSTEKDPVCGTDGR 238
            ||.|:.|..:| :|..   :||.|              .|     ..||..|   ::..||...:
Human    49 ELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNC-----IPCKETC---ENVDCGPGKK 105

  Fly   239 TYLN-----RCMLRVQSCRVGLAAVKLSHVGPCSNTSAVRESCPVDCNSAPKDGPVCSSDGNVYN 298
            ..:|     ||:                              |..||::....||||..||..|.
Human   106 CRMNKKNKPRCV------------------------------CAPDCSNITWKGPVCGLDGKTYR 140

  Fly   299 STCEMKLKTCGQGVVKTSRKHCQSTRMCRESCWRVARPTCGSDGRLYASPCKMRSSNCGKHVFEV 363
            :.|.:....|.:    ......|....|:::|..|..|  ||      |.|.:..:|
Human   141 NECALLKARCKE----QPELEVQYQGRCKKTCRDVFCP--GS------STCVVDQTN-------- 185

  Fly   364 PLSYCMSQERHGASDACPTECPKSDTDSSSQYVCGSDGNIYSSLCELKMLNC------------- 415
             .:||::         |...||  :..||.||:||:||..|||.|.|:...|
Human   186 -NAYCVT---------CNRICP--EPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGK 238

  Fly   416 -----GPQRKSIQKVSMDKC------------------KNRLTRCKQLPPCKDFNSLFGSIFSSK 457
                 ...||..:|.....|                  :.|.:.|.:|  |.|          ||
Human   239 CISRYSGLRKEKEKTEAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDEL--CPD----------SK 291

  Fly   458 RNDKLCGTDAKTYNNECELAHATCLRGV--NLAHIGPCTDLNSPTKD 502
            .::.:|.:|..||.:||.:..|.|..||  .:.|.|.|..::..|::
Human   292 SDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEDTEE 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32354	NP_729380.1	KAZAL_FS	163..>200	CDD:294071	4/7 (57%)
		KAZAL	220..266	CDD:197624	8/50 (16%)
		KAZAL_FS	326..>359	CDD:294071	9/32 (28%)
		KAZAL	380..430	CDD:197624	20/67 (30%)
		KAZAL	452..493	CDD:197624	14/42 (33%)
		KAZAL	502..>536	CDD:197624	0/1 (0%)
		KAZAL_FS	553..597	CDD:294071
		KAZAL	606..650	CDD:197624
FST	XP_005248457.1	FOLN	94..117	CDD:128570	5/25 (20%)
		KAZAL	117..164	CDD:197624	13/80 (16%)
		FOLN	167..190	CDD:128570	9/39 (23%)
		KAZAL	192..239	CDD:197624	17/48 (35%)
		KAZAL	283..329	CDD:197624	18/57 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5159
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840