DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and CADM3

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	XP_024304528.1	Gene:	CADM3 / 57863	HGNCID:	17601	Length:	481	Species:	Homo sapiens

Alignment Length:	413	Identity:	86/413 - (20%)
Similarity:	138/413 - (33%)	Gaps:	104/413 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AWLLLLVVIVMSDMTNGGVQGPIEGYNSLDDLLTTTPTPGQAA----------LLLPTAPTAAYT 66
            |.||||:::.......||.....:||....||...|..|...|          :|....|...:.
Human     6 ASLLLLLLLFACCWAPGGANLSQDGYWQEQDLELGTLAPLDEAISSTVWSSPDMLASQGPLLCWE 70

  Fly    67 HP-----KWMEP---------------------------YFDPSTP--RNVTALMGKSAYLSCRV 97
            ||     ||...                           .|..|.|  .:.|.:.|.:..|.|:|
Human    71 HPLAISWKWNSSNQERNKQTGRGKVVAGRPNVEQQICLCVFRDSQPWTSDETVVAGGTVVLKCQV 135

  Fly    98 RNLANKTVSWIRHRDIHILTVGSYTYTSDQRFQ---ATHHQDTEDWTLQIKWAQKRDAGMYECQI 159
            ::..:.::.|..... ..|..|......|.|.|   :|.|    :.::.|......|.|.|.|.|
Human   136 KDHEDSSLQWSNPAQ-QTLYFGEKRALRDNRIQLVTSTPH----ELSISISNVALADEGEYTCSI 195

  Fly   160 STQPVRSYFVRLNVV-VPTATILGGPDLHVDKGSTINLTCTVKFSPEPPAYIFWYHHEEVINYDS 223
            .|.|||:....:.|: :|...|:.|....:.:..|..|.|....| :|.|.:.|...::.::.:.
Human   196 FTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTATLNCQSSGS-KPAARLTWRKGDQELHGEP 259

  Fly   224 SRGGVSVITE----KGDVTTSFLLIQNADLADSGKYSCAPSNADV------ASVRVHVL-NVRAI 277
            :|     |.|    |....:|.:..|.....|.....|:.::..:      .|.|:.|| ...|:
Human   260 TR-----IQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAM 319

  Fly   278 ISGE--HPEAMQTGSSGC---------QYNW--------LTIVLLLGLVLCYSSQQCSSAVPASL 323
            |..:  ||...|.....|         ||.|        |.:.....|:..:.::..|.....:.
Human   320 IRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEGSVPPLKMTQESALIFPFLNKSDSGTYGCTA 384

  Fly   324 TSSL---------------PLPS 331
            ||::               |:||
Human   385 TSNMGSYKAYYTLNVNDPSPVPS 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	24/99 (24%)
		IG_like	80..175	CDD:214653	25/100 (25%)
		IG_like	184..271	CDD:214653	17/96 (18%)
		IGc2	191..262	CDD:197706	15/74 (20%)
CADM3	XP_024304528.1	Ig1_Necl-1	115..209	CDD:143290	24/98 (24%)
		Ig2_Necl-1	230..312	CDD:143329	17/87 (20%)
		IG_like	328..399	CDD:214653	10/70 (14%)
		4.1m	437..452	CDD:128590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5236
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960