DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and IGSF9

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	284	Identity:	54/284 - (19%)
Similarity:	104/284 - (36%)	Gaps:	74/284 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PTAAYTHPKWME------PYFDPSTPRNVTALMGKSAYLSCRVRNLANKTVSW-IRHRDIHILTV 118
            |...:.:..|:.      |.|..:.|..:.....:...|.|..|......|:| :|.:|:.
Human   118 PEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLG---- 178

  Fly   119 GSYTYTSDQRFQATHHQDTEDWTLQIKWAQKRDAGMYECQI-STQPVRSYFVRLNVVVPTATILG 182
                       |.......::.||:|:..::..:|:|.||. ||:...::..:|.|:.|...::.
Human   179 -----------QGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVP 232

  Fly   183 GPDLHVDKGSTINLTCTVKFSPEPPAYIFWYHHEEVINYDSSRGGVSVITEKGDVTTSFLLIQNA 247
            ..:..|:....::|.|..:..|....|.::..:..|.:....:..|.::.: |.:.   ||....
Human   233 PKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVD-GSLR---LLATQP 293

  Fly   248 DLADSGKYSCAPSNADVASVRVHVLNVRAIISGEHPEAMQTGSSGCQYNWLTIVLLLGLVLCYSS 312
            |  |:|.|:|.|||..:                 ||.:...        :||::
Human   294 D--DAGCYTCVPSNGLL-----------------HPPSASA--------YLTVL----------- 320

  Fly   313 QQCSSAVPASLTSSLPLPSQLPLP 336
                  .||.:|:   :|.:.|||
Human   321 ------YPAQVTA---MPPETPLP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	19/96 (20%)
		IG_like	80..175	CDD:214653	20/96 (21%)
		IG_like	184..271	CDD:214653	18/86 (21%)
		IGc2	191..262	CDD:197706	16/70 (23%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	2/13 (15%)
		IG_like	28..110	CDD:214653
		I-set	136..223	CDD:254352	21/101 (21%)
		Ig	154..220	CDD:143165	17/80 (21%)
		Ig_3	226..305	CDD:290638	17/84 (20%)
		IG_like	233..319	CDD:214653	21/116 (18%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810