DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and lrit3a

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio

Alignment Length:	239	Identity:	47/239 - (19%)
Similarity:	74/239 - (30%)	Gaps:	70/239 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LTTTPTPGQAALL----LPTAPTAAYTHPKWMEPYFDP---------STPRNVTALMGKSAYLSC 95
            ||:.|......|:    |..:.....|.|..:...:.|         ::.:.|..|.....|..|
Zfish   141 LTSVPVEAAPYLINITYLDISSNKLTTLPSDLVDIWPPFSGIQPSANTSQKTVLGLQDNPWYCDC 205

  Fly    96 RVRNLANKTVSWIRHRDI------HILTVGSYTYTSDQRFQATHHQDTEDWTLQIKWAQKRDAGM 154
            |:    :|.:...:...|      .:||.....:.|...||.                    |.:
Zfish   206 RI----SKLIELSKMAGIPVVLMDQVLTCSGPEHLSGVLFQR--------------------AEL 246

  Fly   155 YECQISTQPVRSYFVRLNVVVPTATILGGPDLHVDKGSTINLTCTVKFSPEPPAYIFWYHHEEVI 219
            .:|...|            |:.:||.:..|     .||.:.|.|.....|.|.  :.|      .
Zfish   247 DQCVKPT------------VMTSATKITSP-----LGSNVLLRCDANGFPTPT--LLW------T 286

  Fly   220 NYDSSRGGVSVITEK-GD-VTTSFLLIQNADLADSGKYSCAPSN 261
            ..|.|....:|:.|. |: |..|.|.:.:....|:|.|.|...|
Zfish   287 TADGSVVNNTVVQESPGEGVRWSILSLHSIVFKDAGDYRCKAKN 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	15/100 (15%)
		IG_like	80..175	CDD:214653	15/100 (15%)
		IG_like	184..271	CDD:214653	21/80 (26%)
		IGc2	191..262	CDD:197706	20/73 (27%)
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566	47/239 (20%)
		leucine-rich repeat	83..106	CDD:275378
		LRR_4	107..145	CDD:289563	2/3 (67%)
		leucine-rich repeat	107..130	CDD:275378
		LRR_8	129..>171	CDD:290566	7/29 (24%)
		LRR_4	129..170	CDD:289563	6/28 (21%)
		leucine-rich repeat	131..154	CDD:275378	4/12 (33%)
		leucine-rich repeat	155..168	CDD:275378	1/12 (8%)
		TPKR_C2	199..249	CDD:301599	11/73 (15%)
		Ig	252..343	CDD:299845	25/104 (24%)
		IG_like	261..343	CDD:214653	21/83 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900