Protein Alignment dpr6 and NCAM2

DIOPT Version :10

• Sequence 1: NP_001287018.1
• Gene: dpr6 / 50296
• FlyBaseID: FBgn0040823
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: XP_011527877.1
• Gene: NCAM2 / 4685
• HGNCID: 7657
• Length: 874
• Species: Homo sapiens
• Alignment Length: 181
• Identity: 47/181 - (25%)
• Similarity: 73/181 - (40%)
• Gaps: 31/181 - (17%)

  Fly    88 GKSAYLSCRVRNLANKTVSWIRHRDIHILTVGSYTYTSDQRFQATHHQDTEDWTLQIKWAQKRDA 152
            |:.|.:.|||.:.....|||:.|.:       ..|..||.||....:.:     |||....|.|.
Human   154 GEDAEVVCRVSSSPAPAVSWLYHNE-------EVTTISDNRFAMLANNN-----LQILNINKSDE 206

  Fly   153 GMYECQISTQ-----PVRSYFVRLNVVVPTATILGGPDLH--VDKGSTINLTCTVKFSPEPPAYI 210
            |:|.|:...:     ..|...|.:|  ||.|..:.....:  .::|..:..:|....||||.  |
Human   207 GIYRCEGRVEARGEIDFRDIIVIVN--VPPAISMPQKSFNATAERGEEMTFSCRASGSPEPA--I 267

  Fly   211 FWYHHEEVINYDSSRGGVSVITEKGDVTTSFLLIQNADLADSGKYSCAPSN 261
            .|:.:.::|..:..      ...||..|.  |.::|...:|.|.|.|..:|
Human   268 SWFRNGKLIEENEK------YILKGSNTE--LTVRNIINSDGGPYVCRATN 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	FR1	79..96	CDD:409355	2/7 (29%)
		IG_like	80..175	CDD:214653	25/91 (27%)
		Ig strand A'	83..85	CDD:409355
		Ig strand B	89..97	CDD:409355	2/7 (29%)
		CDR1	97..104	CDD:409355	1/6 (17%)
		FR2	105..114	CDD:409355	4/8 (50%)
		Ig strand C	105..110	CDD:409355	3/4 (75%)
		CDR2	115..129	CDD:409355	3/13 (23%)
		Ig strand D	129..135	CDD:409355	1/5 (20%)
		FR3	130..159	CDD:409355	8/28 (29%)
		Ig strand E	139..145	CDD:409355	2/5 (40%)
		Ig strand F	153..160	CDD:409355	3/6 (50%)
		IG_like	184..271	CDD:214653	19/80 (24%)
		Ig strand B	194..198	CDD:409353	0/3 (0%)
		Ig strand C	209..213	CDD:409353	1/3 (33%)
		Ig strand E	240..244	CDD:409353	1/3 (33%)
		Ig strand F	254..259	CDD:409353	2/4 (50%)
		Ig strand G	268..271	CDD:409353
NCAM2	XP_011527877.1	IgI_1_NCAM-2	46..138	CDD:409452
		Ig strand A	46..51	CDD:409452
		Ig strand A'	54..58	CDD:409452
		Ig strand B	60..70	CDD:409452
		Ig strand C	74..80	CDD:409452
		Ig strand C'	83..85	CDD:409452
		Ig strand D	91..97	CDD:409452
		Ig strand E	99..107	CDD:409452
		Ig strand F	114..121	CDD:409452
		Ig strand G	126..137	CDD:409452
		Ig	142..218	CDD:472250	22/75 (29%)
		Ig strand C	170..174	CDD:409353	2/3 (67%)
		Ig strand E	193..197	CDD:409353	0/8 (0%)
		IgI_1_MuSK	234..323	CDD:409562	20/87 (23%)
		Ig strand A	234..237	CDD:409562	1/2 (50%)
		Ig strand A'	242..247	CDD:409562	0/4 (0%)
		Ig strand B	253..260	CDD:409562	1/6 (17%)
		Ig strand C	266..271	CDD:409562	2/6 (33%)
		Ig strand C'	273..275	CDD:409562	0/1 (0%)
		Ig strand D	282..285	CDD:409562	0/2 (0%)
		Ig strand E	289..295	CDD:409562	2/7 (29%)
		Ig strand F	302..309	CDD:409562	3/6 (50%)
		Ig strand G	315..323	CDD:409562
		IgI_NCAM-2	325..422	CDD:143278
		Ig strand A	325..330	CDD:143278
		Ig strand A'	334..338	CDD:143278
		Ig strand B	342..350	CDD:143278
		Ig strand C	356..362	CDD:143278
		Ig strand C'	365..368	CDD:143278
		Ig strand D	378..384	CDD:143278
		Ig strand E	387..393	CDD:143278
		Ig strand F	401..409	CDD:143278
		Ig strand G	412..422	CDD:143278
		Ig_3	426..504	CDD:464046
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:394996