DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and NCAM1

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	350	Identity:	72/350 - (20%)
Similarity:	116/350 - (33%)	Gaps:	106/350 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 GKSAYLSCRVRNLANKTVSWIRH--RDIHILTVGSYTYTSDQRFQATHHQDTEDWTLQIKWAQKR 150
            |:.|.:.|.|.:....|:.| :|  ||:.:        ..|.||....:.     .|||:..:|.
Human   132 GEDAVIVCDVVSSLPPTIIW-KHKGRDVIL--------KKDVRFIVLSNN-----YLQIRGIKKT 182

  Fly   151 DAGMYECQ-----------------ISTQPVRSYFVRLNVVVPTATILGGPDLHVDKGSTINLTC 198
            |.|.|.|:                 ::..|  :...|.|:|..||.:          |.::.|.|
Human   183 DEGTYRCEGRILARGEINFKDIQVIVNVPP--TIQARQNIVNATANL----------GQSVTLVC 235

  Fly   199 TVKFSPEPPAYIFWYHHEEVINYDSSRGGVSVITEKGDV------TTSFLLIQNADLADSGKYSC 257
            ..:..|||.  :.|           ::.|..:..|:.|.      .:|.|.|:..|..|..:|.|
Human   236 DAEGFPEPT--MSW-----------TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287

  Fly   258 APSN---ADVASVRVHVLNVRAIISGEHPEAMQ-----------TGSSGCQYNWLTIVLLLGLVL 308
            ...|   ...|::.:.|.....|...|:..||:           :|.......|.|
Human   288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRT--------- 343

  Fly   309 CYSSQQCSSAVPASLTSSLPLPSQLPLP----------AAAAATTTATGESASSESVTAARASAA 363
              |::..||...||.|.  |...::..|          .|.:|....:.|:.....|..:.|..:
Human   344 --STRNISSEEKASWTR--PEKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVS 404

  Fly   364 TTTT-----TTATRKRCPAVKSCRQ 383
            :.|.     |.|....|.|..:..|
Human   405 SLTLKSIQYTDAGEYICTASNTIGQ 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	23/104 (22%)
		IG_like	80..175	CDD:214653	23/105 (22%)
		IG_like	184..271	CDD:214653	19/95 (20%)
		IGc2	191..262	CDD:197706	18/79 (23%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	19/71 (27%)
		Ig	211..307	CDD:325142	26/120 (22%)
		Ig	306..438	CDD:325142	25/136 (18%)
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810