DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and Dscam1

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	303	Identity:	75/303 - (24%)
Similarity:	117/303 - (38%)	Gaps:	96/303 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VAWLLLLVVIVMSD------MTNGGVQGPIEGYNSLDDLLTTTPTPGQAALLLPTAPTAAYTHPK 69
            |:..|::...|:.|      :.|..|.|     .|::.:||.            |||.:|
  Fly   307 VSGTLIIKDAVVEDSGKYLCVVNNSVGG-----ESVETVLTV------------TAPLSA----- 349

  Fly    70 WMEPYFDPSTPRNVTALMGKSAYLSCRVRNLANKTVSWIRHRDIHILTVGSYTYTSDQRFQATHH 134
                ..||.|.   |...|:.|..:|:......|||||::..                  :|..|
  Fly   350 ----KIDPPTQ---TVDFGRPAVFTCQYTGNPIKTVSWMKDG------------------KAIGH 389

  Fly   135 QDTEDWTLQIKWAQKRDAGMYECQISTQPVRSYFVRLNVVVPTATI---LGG----PDLH----- 187
            .:.   .|:|:..:|.|.|||:|          |||.:.....|:.   |||    |.:.
  Fly   390 SEP---VLRIESVKKEDKGMYQC----------FVRNDQESAEASAELKLGGRFDPPVIRQAFQE 441

  Fly   188 --VDKGSTINLTCTVKFSPEPPAYIFW-YHHEEVINYDSSRGGVSVITEKGDVTTSFLLIQNADL 249
              ::.|.::.|.|....:|.|.  |.| ...:::.|.|..:.| ..:|..||| .|:|.|.:...
  Fly   442 ETMEPGPSVFLKCVAGGNPTPE--ISWELDGKKIANNDRYQVG-QYVTVNGDV-VSYLNITSVHA 502

  Fly   250 ADSGKYSC-APSNADVA--SVRVHV--------LNVRAIISGE 281
            .|.|.|.| |.|...||  |.:::|        :..:||::||
  Fly   503 NDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIVAGE 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	23/94 (24%)
		IG_like	80..175	CDD:214653	22/94 (23%)
		IG_like	184..271	CDD:214653	27/97 (28%)
		IGc2	191..262	CDD:197706	23/72 (32%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	9/40 (23%)
		Ig	269..340	CDD:143165	8/37 (22%)
		IG_like	353..425	CDD:214653	25/105 (24%)
		IGc2	361..413	CDD:197706	20/82 (24%)
		I-set	433..527	CDD:254352	27/97 (28%)
		IGc2	446..517	CDD:197706	23/74 (31%)
		I-set	533..618	CDD:254352	4/13 (31%)
		IGc2	544..607	CDD:197706	2/2 (100%)
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900