DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001101611.1	Gene:	Dscaml1 / 315615	RGDID:	1304887	Length:	2111	Species:	Rattus norvegicus

Alignment Length:	338	Identity:	76/338 - (22%)
Similarity:	124/338 - (36%)	Gaps:	95/338 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 RNVTALMGKSAYLSCRVRNLANKTVSWIRHRDIHILTVGSYTYTSDQRFQATHHQDT-EDWTLQI 144
            ||:||:.|:...::|||......::.|  ::|..:|             ...|.|.. |:.||::
  Rat   570 RNITAVAGRDTLINCRVIGYPYYSIKW--YKDALLL-------------PDNHRQVVFENGTLKL 619

  Fly   145 KWAQK-RDAGMYECQISTQPVRSYFVRLNVVV-----------PTATILGGPDLHVDKGSTINLT 197
            ...|| .|.|.|.|.:..||..|....::|.|           |.|:|          |..:.:.
  Rat   620 TDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI----------GQLLYIP 674

  Fly   198 CTVKFSPEPPAYIFWYHHEEVINYDSSRGGVSVITEKGDVTTSFLLIQNADLADSGKYSCAPSNA 262
            |.|. |.:.|..|.|....:||   .|..||::.:::   ..|.|.|.:..|..:|.|:|..|||
  Rat   675 CVVS-SGDMPIRITWRKDGQVI---ISGSGVTIESKE---FMSSLQISSVSLKHNGNYTCIASNA 732

  Fly   263 DVASVRVHVLNVRA----IISGEH--------------------PEAMQTGSSGC----QYNWLT 299
            .....|...|.||.    ::...:                    |:.|...:.|.    ||:.:.
  Rat   733 AATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVP 797

  Fly   300 IV----------LL--------LGLVLCYSSQQCSSAVPASLTSSLPLPSQLPLPAAAAATTTAT 346
            :.          ||        :|..||    |.|:.|...::.::.|..::|....:...||..
  Rat   798 LTGRIQILPNSSLLIRHVLEEDIGYYLC----QASNGVGTDISKAMFLTVKIPAMITSHPNTTIA 858

  Fly   347 GESASSESVTAAR 359
            .:..:.|....||
  Rat   859 IKGHAKELNCTAR 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	25/94 (27%)
		IG_like	80..175	CDD:214653	26/95 (27%)
		IG_like	184..271	CDD:214653	23/86 (27%)
		IGc2	191..262	CDD:197706	20/70 (29%)
Dscaml1	NP_001101611.1	IG	101..173	CDD:214652
		IGc2	101..168	CDD:197706
		Ig	183..276	CDD:299845
		IG_like	195..276	CDD:214653
		I-set	291..369	CDD:254352
		IGc2	298..359	CDD:197706
		IGc2	386..447	CDD:197706
		I-set	466..560	CDD:254352
		Ig	466..556	CDD:299845
		IGc2	577..635	CDD:197706	18/72 (25%)
		IG_like	665..744	CDD:214653	26/95 (27%)
		Ig	673..739	CDD:143165	21/72 (29%)
		I-set	748..843	CDD:254352	14/98 (14%)
		Ig7_DSCAM	765..843	CDD:143211	14/81 (17%)
		I-set	849..942	CDD:254352	5/23 (22%)
		Ig	861..949	CDD:299845	3/11 (27%)
		FN3	945..1039	CDD:238020
		FN3	1046..1143	CDD:238020
		fn3	1151..1237	CDD:278470
		FN3	1249..1340	CDD:238020
		IGc2	1364..1428	CDD:197706
		FN3	1442..1532	CDD:238020
		FN3	1546..1618	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810