DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and Jaml

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	XP_038938277.1	Gene:	Jaml / 315610	RGDID:	1562572	Length:	379	Species:	Rattus norvegicus

Alignment Length:	345	Identity:	78/345 - (22%)
Similarity:	146/345 - (42%)	Gaps:	81/345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 MGKSAYLSCRVRNLANK---TVSWIRHRDIH-----ILTVGSYTYTS----DQRFQATHHQDTE- 138
            :|:||.:.|.|::...|   .|.|:..:..|     :|    |.|:|    ..|||.......:
  Rat    37 VGESALMGCVVQSTEEKPVDKVDWVFSKGEHAENEYVL----YYYSSLSVPTGRFQNRSRLVGDL 97

  Fly   139 ---DWTLQIKWAQKRDAGMYECQISTQ---PVRSYFVRLNVVVPTATILGGPDLHVDKGSTINLT 197
               |.:|.::..||.|.|:|.|:|..:   .|...||.|:|:....     .:|.|..|..|.:.
  Rat    98 LRNDGSLLLQDVQKADEGIYTCEIRLKNEGSVSKKFVLLHVLPEEP-----KELRVHVGDPIQMG 157

  Fly   198 CTVKFSPE-PPAYIFWY-----HHEE--VINYDSS------------RGGVSVITEKGDVTTS-- 240
            |..:.:.| ....:.|.     |.:|  |::||.:            |..|.:   .||::.:
  Rat   158 CFFRSTEERRVTRVNWMFSSGKHAQEEIVLSYDFNMHSGTFQGQGRFRNRVDL---TGDISRNDG 219

  Fly   241 FLLIQNADLADSGKYSCAPSNADVASVRVHVLNVRAIISGEHPEAMQ--TGSSGCQYNWL---TI 300
            .:::|....:|.|.|:|:.....:.|.:..||:|   |..|.|.::.  |.::|.|...|   .:
  Rat   220 SIMLQTVKKSDQGVYTCSIYLGKLESRKTIVLHV---IQDESPRSISTTTETAGKQQGILDGNQL 281

  Fly   301 VLLLGLVLCYSSQQCSSAVPASLTSSLPLPSQLPLPA-----AAAATTTATGESASSESVTAARA 360
            |:::|:|       |::.        |.||..:.:..     .::.::.|:.:|..::..|::..
  Rat   282 VIIVGIV-------CATL--------LLLPVLILIVKKTKWNKSSVSSIASVKSLENKEKTSSEK 331

  Fly   361 SAATTTTTTATRKRCPAVKS 380
            ...::.||..|.:|.|:.:|
  Rat   332 HVYSSITTWETAERGPSGES 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	29/105 (28%)
		IG_like	80..175	CDD:214653	30/106 (28%)
		IG_like	184..271	CDD:214653	22/108 (20%)
		IGc2	191..262	CDD:197706	19/92 (21%)
Jaml	XP_038938277.1	V-set	33..139	CDD:400157	29/105 (28%)
		FR2	58..69	CDD:409353	3/10 (30%)
		CDR2	70..82	CDD:409353	4/15 (27%)
		Ig strand C'	71..77	CDD:409353	2/9 (22%)
		Ig strand C'	78..82	CDD:409353	1/3 (33%)
		FR3	87..121	CDD:409353	10/33 (30%)
		Ig strand D	90..96	CDD:409353	0/5 (0%)
		Ig strand E	100..108	CDD:409353	2/7 (29%)
		Ig strand F	115..122	CDD:409353	3/6 (50%)
		V-set	141..253	CDD:400157	24/119 (20%)
		Ig strand A'	144..150	CDD:409353	2/5 (40%)
		Ig strand B	152..162	CDD:409353	2/9 (22%)
		CDR1	162..169	CDD:409353	1/6 (17%)
		Ig strand C	169..176	CDD:409353	1/6 (17%)
		FR2	170..181	CDD:409353	1/10 (10%)
		CDR2	182..196	CDD:409353	4/13 (31%)
		Ig strand C'	183..189	CDD:409353	2/5 (40%)
		Ig strand C'	191..196	CDD:409353	0/4 (0%)
		FR3	204..238	CDD:409353	9/36 (25%)
		Ig strand D	207..213	CDD:409353	1/8 (13%)
		Ig strand E	217..225	CDD:409353	0/7 (0%)
		Ig strand F	232..238	CDD:409353	3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	48	1.000	Inparanoid score	I5388
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050