DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr6 and Igsf9

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	74/404 - (18%)
Similarity:	126/404 - (31%)	Gaps:	151/404 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WLLLLVVIVMSDMTNGGVQGPIEGYNSLDDLLTTTPTPGQAAL----LLPTAPTAAYTHPKWM-- 71
            |.|.|.  ::|.:.:.|..|     ....::::.....|::|:    |||.|........:|:
  Rat     3 WCLRLT--ILSLILSQGADG-----RRKPEVVSVVGRAGESAVLGCDLLPPAGRPPLHVIEWLRF 60

  Fly    72 -------------EPYFDPSTPRNVTALMGKS-----------AYLSCRV---------RNLANK 103
                         .|..||.....|....|.|           .:..|||         ::.||.
  Rat    61 GFLLPIFIQFGLYSPRIDPDYVGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANG 125

  Fly   104 TVSWIRHRDIHILTVGSYTYTSDQRFQAT-------------------------------HHQD- 136
              ||     :|:      |..|..:||.|                               ..||
  Rat   126 --SW-----VHL------TVNSPPQFQETPPLVLEVKELEAVTLRCVALGSPQPYVTWKFRGQDL 177

  Fly   137 --------TEDWTLQIKWAQKRDAGMYECQI-STQPVRSYFVRLNVVVPTATILGGPDLHVDKGS 192
                    ..:.||.|:..::..||.|.||. ||:...::..:|.|:.|...::...:..|:...
  Rat   178 GKGQGQVQVRNGTLWIRRVERGSAGDYTCQASSTEGSVTHTTQLLVLGPPVIVVPPNNNTVNASQ 242

  Fly   193 TINLTCTVKFSPEPPAYIFWYHHEEVINYDSSRGGVSVITEKGDVTTSFLLIQNADLADSGKYSC 257
            .::|.|..:..|....|.::.....|.:....:..|.::.:      ..|.:|.....|:|.|:|
  Rat   243 DVSLACRAEAYPANLTYSWFQDRINVFHISRLQSRVRILVD------GSLWLQATQPDDAGHYTC 301

  Fly   258 APSNADVASVRVHVLNVRAIISGEHPEAMQTGSSGCQYNWLTIVLLLGLVLCYSSQQCSSAVPAS 322
            .|||                 ...||.:...        :||::                 .||.
  Rat   302 VPSN-----------------GFPHPPSASA--------YLTVL-----------------YPAQ 324

  Fly   323 LTSSLPLPSQLPLP 336
            :|   .:|.:.|||
  Rat   325 VT---VMPPETPLP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	29/155 (19%)
		IG_like	80..175	CDD:214653	30/155 (19%)
		IG_like	184..271	CDD:214653	16/86 (19%)
		IGc2	191..262	CDD:197706	14/70 (20%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	14/81 (17%)
		Ig strand A	136..139	CDD:409353	0/2 (0%)
		IG_like	143..223	CDD:214653	13/79 (16%)
		Ig strand A'	145..148	CDD:409353	0/2 (0%)
		Ig strand B	154..161	CDD:409353	0/6 (0%)
		Ig strand C	167..172	CDD:409353	0/4 (0%)
		Ig strand C'	175..177	CDD:409353	1/1 (100%)
		Ig strand D	183..187	CDD:409353	0/3 (0%)
		Ig strand E	189..193	CDD:409353	2/3 (67%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	1/9 (11%)
		Ig_3	226..305	CDD:404760	15/84 (18%)
		putative Ig strand A	226..230	CDD:409353	1/3 (33%)
		putative Ig strand A'	235..239	CDD:409353	0/3 (0%)
		putative Ig strand B	241..251	CDD:409353	2/9 (22%)
		putative Ig strand C'	267..270	CDD:409353	1/2 (50%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	1/5 (20%)
		putative Ig strand F	297..305	CDD:409353	4/7 (57%)
		putative Ig strand G	310..319	CDD:409353	2/16 (13%)
		Ig	322..407	CDD:416386	7/17 (41%)
		Ig strand A'	324..328	CDD:409353	1/6 (17%)
		Ig strand B	333..347	CDD:409353	3/3 (100%)
		Ig strand C	353..359	CDD:409353
		Ig strand C'	362..364	CDD:409353
		Ig strand D	371..374	CDD:409353
		Ig strand E	378..382	CDD:409353
		Ig strand F	391..399	CDD:409353
		Ig	418..503	CDD:416386
		Ig strand A	418..421	CDD:409353
		Ig strand A'	427..430	CDD:409353
		Ig strand B	436..443	CDD:409353
		Ig strand C	449..454	CDD:409353
		Ig strand C'	457..459	CDD:409353
		Ig strand D	462..466	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	482..490	CDD:409353
		Ig strand G	493..503	CDD:409353
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900