DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and Tyro3

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_058788.1	Gene:	Tyro3 / 25232	RGDID:	3923	Length:	880	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	80/362 - (22%)
Similarity:	131/362 - (36%)	Gaps:	73/362 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GQAALLLPTAPTAAYTHPKWMEPYFDPSTPRNVTALMGKSAYLSCRVRNLANKTVSWIRHRDIHI 115
            |.|:||||.:..|..   |.|      ..|..:|...|:...|:|.|..:.:..:.|::.
  Rat    19 GLASLLLPGSAAAGL---KLM------GAPVKMTVSQGQPVKLNCSVEGMDDPDIHWMKD----- 69

  Fly   116 LTVGSYTYTSDQRFQATHHQDTEDW--TLQIKWAQKRDAGMYECQI----STQPVRSYFVRLNVV 174
               |:....:.|...:...|   :|  .|.:|.|::.|||:|.||:    .|:..:|.::
  Rat    70 ---GAVVQNASQVSISISEQ---NWIGLLSLKSAERSDAGLYWCQVKDGEETKISQSVWL----- 123

  Fly   175 VPTATILGGP-------DLHVDKGSTINLTCTVKFSPEPPAYIFWYHHEEVINYDSSRGGVSVIT 232
                |:.|.|       ||.|.......|:|.....|| |..|||:           ||.    |
  Rat   124 ----TVEGVPFFTVEPKDLAVPPNVPFQLSCEAVGPPE-PVTIFWW-----------RGP----T 168

  Fly   233 EKGDVTTSFLLIQNADLADSGKYSCAPSN-ADVASVRVHVLNVRAIISGEHPEAMQT-GSSGCQY 295
            :.|...:|..::....:....::||...| ..:|:.|..::.::|..:......:.| .||....
  Rat   169 KVGGPASSPSVLNVTGVTQRTEFSCEAHNIKGLATSRPAIIRLQAPPAAPFNITVTTISSSNASV 233

  Fly   296 NWLTIVLLLGLVLCYSSQQCSSAVPA---SLTSSLPLPSQLPLPAAAAATTTATGESASSESVTA 357
            .|  :....||.|.:|.....:..|.   :|...:|:|   |..........||..|.......|
  Rat   234 AW--VPGADGLALLHSCTVQVAHAPGEWEALAVVVPVP---PFTCLLRNLAPATNYSLRVRCANA 293

  Fly   358 ARASAATTTTTTATRKRCPA-----VKSCRQTAGRVL 389
            ...|.........|:...||     ..:.|..:|.:|
  Rat   294 LGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLIL 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	22/100 (22%)
		IG_like	80..175	CDD:214653	22/100 (22%)
		IG_like	184..271	CDD:214653	22/94 (23%)
		IGc2	191..262	CDD:197706	16/71 (23%)
Tyro3	NP_058788.1	IG_like	39..125	CDD:214653	22/105 (21%)
		IGc2	46..111	CDD:197706	18/75 (24%)
		Ig2_Tyro3_like	131..209	CDD:143226	21/93 (23%)
		IG_like	135..204	CDD:214653	20/84 (24%)
		FN3	215..307	CDD:238020	18/96 (19%)
		fn3	315..396	CDD:278470	3/16 (19%)
		PTKc_Tyro3	498..781	CDD:270659
		Pkinase_Tyr	508..776	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..827
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	842..864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910