DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and Lrit1

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	82/426 - (19%)
Similarity:	128/426 - (30%)	Gaps:	126/426 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PIEGYNSLDDLLTTTPTPGQAALLLPTAPTAAYTHPKWMEPYFDPSTPRNVTALMGKSAYLSCRV 97
            |.|..:.|:: ||.........:.||......:.|.| ..||......|.|..|........||:
  Rat   147 PPEAVHFLEN-LTFLDLSNNQLMRLPEELLDTWAHLK-TGPYLSSRRTRLVLGLQDNPWVCDCRL 209

  Fly    98 RNLANKTVSWIRHRDIHILTVGSYTYTSDQRFQATHHQDTEDWTLQIKWAQKR--------DAGM 154
            .:|            :|:|                     :.|...:.:.:.|        .||:
  Rat   210 YDL------------VHLL---------------------DGWASNLIFIEARLRCGSPRSLAGV 241

  Fly   155 YECQISTQPVRSYFVRLNVVVPTATILGGPDLHVDKGSTINLTCTVKFSPEPPAYIFWYH----- 214
            ...|:..:..:|..:|     |..|.:..|     .|||:.|.|.....|.|.  :.|..
  Rat   242 AFSQLELRKCQSPELR-----PGVTSIISP-----LGSTVLLRCGATGIPGPE--MSWRRANGRP 294

  Fly   215 -----HEEVINYDSSRGGVSVITEKGDVTTSFLLIQNADLADSGKYSCAPSN-ADVASVRVHVLN 273
                 |:||    ||.|.          :.:.|.:....|.|||.|.|...| ...:...:.::.
  Rat   295 LNGTVHQEV----SSDGS----------SWTLLDLPVVSLFDSGDYICQAKNFLGASETLISLIV 345

  Fly   274 VRAIISGEH---PEAMQT----GSSGCQYNWLTIVLLLGLVLCYSSQQCSSAVPASLTSSLPLPS 331
            .....|.|:   |.|:..    |:....||...:...:..|....:.....:|| |:...|||.:
  Rat   346 TEPQTSTEYTGIPGALWARTGEGAEAAAYNNKLVARHVPHVPEPVALATKPSVP-SIKEELPLQN 409

  Fly   332 -QLPLP------------AAAAATTTATGESASSESVTAARASAATTT----------------- 366
             |:.:|            .....:....|::..|.|:......|..||
  Rat   410 FQMDVPGEFSREPSEHQETQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGQRDMRRM 474

  Fly   367 ------TTTATRKRCPAVK--SCRQTAGRVLTKRSC 394
                  |:.......|..|  :|....|.|.||..|
  Rat   475 TVEAGKTSVTIEGLAPKTKYVACVCVRGLVPTKEQC 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	15/102 (15%)
		IG_like	80..175	CDD:214653	15/102 (15%)
		IG_like	184..271	CDD:214653	23/97 (24%)
		IGc2	191..262	CDD:197706	22/81 (27%)
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..128
		LRR_8	131..>176	CDD:290566	7/29 (24%)
		LRR_4	131..172	CDD:289563	6/25 (24%)
		LRR 4	132..153		2/5 (40%)
		leucine-rich repeat	133..156	CDD:275378	3/8 (38%)
		LRR 5	156..177		4/21 (19%)
		leucine-rich repeat	157..180	CDD:275378	4/22 (18%)
		leucine-rich repeat	181..205	CDD:275378	6/24 (25%)
		TPKR_C2	201..>240	CDD:301599	7/71 (10%)
		Ig	257..345	CDD:299845	26/113 (23%)
		IG_like	267..345	CDD:214653	22/93 (24%)
		FN3	431..501	CDD:214495	10/69 (14%)
		LRR 6	525..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900