DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr6 and CADM4

DIOPT Version :9

Sequence 1:NP_001287018.1 Gene:dpr6 / 50296 FlyBaseID:FBgn0040823 Length:396 Species:Drosophila melanogaster
Sequence 2:NP_660339.1 Gene:CADM4 / 199731 HGNCID:30825 Length:388 Species:Homo sapiens


Alignment Length:253 Identity:61/253 - (24%)
Similarity:100/253 - (39%) Gaps:54/253 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 ALMGKSAYLSCRV-RNLANKTVSWIRHRDIHILTVGSYTYTSDQRFQATHHQDTEDW----TLQI 144
            |:.|....|||.| |:....|:.|.|.|             .:.:..::..::.:.|    |::.
Human   135 AVEGGEVELSCLVPRSRPAATLRWYRDR-------------KELKGVSSSQENGKVWSVASTVRF 186

  Fly   145 KWAQKRDAGMYECQISTQPVRSYFVRLNVVV------PTATILGGPDLHVDKGSTINLTCTVKFS 203
            :..:|.|.|:..|:...|.:.|...:....|      |||.|.....: |.:|.|:.|||.|..:
Human   187 RVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDV
QYSPTARIHASQAV-VREGDTLVLTCAVTGN 250

  Fly   204 PEPPAYIFWYHHEEVINYDSSRGGVSVITEKGDVTTSFLLIQNADLADSGKYSCAPSNADVASVR 268
            |. |..|.|           :||..| :.|:.:.....|.:.....||:|.|:|..||....:..
Human   251 PR-PNQIRW-----------NRGNES-LPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARA 302

  Fly   269 VHVLNVRAIISGEHPEAMQTGSSGCQYN----------WLTIVLLLGLVLCYSSQQCS 316
            ::||.|      ..|.|:....:...|.          :|.|.:|:|:|.|...|:.|
Human   303 LYVLVV------YDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGS 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr6NP_001287018.1 V-set 79..174 CDD:284989 19/93 (20%)
IG_like 80..175 CDD:214653 19/94 (20%)
IG_like 184..271 CDD:214653 23/86 (27%)
IGc2 191..262 CDD:197706 21/70 (30%)
CADM4NP_660339.1 Ig 29..120 CDD:416386
FR1 29..45 CDD:409353
Ig strand A' 30..36 CDD:409353
Ig strand B 38..46 CDD:409353
CDR1 46..51 CDD:409353
FR2 52..59 CDD:409353
Ig strand C 52..58 CDD:409353
CDR2 60..71 CDD:409353
Ig strand C' 62..66 CDD:409353
Ig strand C' 68..71 CDD:409353
FR3 72..107 CDD:409353
Ig strand D 76..83 CDD:409353
Ig strand E 86..92 CDD:409353
Ig strand F 99..107 CDD:409353
CDR3 108..111 CDD:409353
Ig strand G 111..120 CDD:409353
FR4 113..120 CDD:409353
IgI_2_Necl-4 121..220 CDD:409468 20/97 (21%)
Ig strand B 141..145 CDD:409468 1/3 (33%)
Ig strand C 155..159 CDD:409468 1/3 (33%)
Ig strand E 182..186 CDD:409468 1/3 (33%)
Ig strand F 196..201 CDD:409468 1/4 (25%)
Ig strand G 213..216 CDD:409468 0/2 (0%)
Ig_3 224..295 CDD:404760 25/84 (30%)
Ig strand A' 231..235 CDD:409353 0/4 (0%)
Ig strand B 241..248 CDD:409353 3/6 (50%)
Ig strand C 255..260 CDD:409353 2/15 (13%)
Ig strand C' 262..264 CDD:409353 0/1 (0%)
Ig strand E 274..280 CDD:409353 1/5 (20%)
Ig strand F 287..294 CDD:409353 3/6 (50%)
Ig strand G 300..308 CDD:409353 2/7 (29%)
4.1m 344..362 CDD:128590 4/11 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 79 1.000 Inparanoid score I5236
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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