DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr6 and rig-4

DIOPT Version :9

Sequence 1:	NP_001287018.1	Gene:	dpr6 / 50296	FlyBaseID:	FBgn0040823	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_501339.2	Gene:	rig-4 / 177597	WormBaseID:	WBGene00004371	Length:	2325	Species:	Caenorhabditis elegans

Alignment Length:	404	Identity:	79/404 - (19%)
Similarity:	143/404 - (35%)	Gaps:	110/404 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VMSDMTNGGVQGPIEGYNSLDDLLT-TTPTPGQAALLLPTAPTAAYTHPKWMEPYF------DPS 78
            |.::|:..|:        ||::.:: .||.|.:...         :.:.|..|..|      :||
Worm   410 VATEMSEDGM--------SLEEEISMETPPPRKLKF---------FDNSKSQEQLFPFTSELEPS 457

  Fly    79 -----TPRNVTALMGKS-AYLSCRVRNLANKTVSWIRHRDIHILTVGSYTYTSDQRFQATHHQDT 137
                 ||:::|...|.. ..:.|.........:.|:.:        |....|.:.::..|:.
Worm   458 QKLIKTPKDLTVASGTDRIMMECAATGSPPPNIIWLLN--------GHEIQTDNVKYDLTND--- 511

  Fly   138 EDWTLQIKWAQKRDAGMYECQISTQPVRSYFVRLNVVVPTATIL--GGPDLHVDKGSTINLTCTV 200
               .|.|...:|.|.|.|.|:||...|::   ..||.|...:::  |..|.....|:.:..:|.|
Worm   512 ---GLAIHDIRKSDEGEYTCEISGSNVKA---TANVQVNGDSLIEYGPADQKSLIGTNVEFSCEV 570

  Fly   201 KFSPEPPAYIFWYHHEEVINYDSSRGGVSVITEKGDVTTSFLLIQNADLADSGKYSC---APSNA 262
            .......|.:.||.::.::..:.:.|.......||.     |:|:.....::|:|.|   .....
Worm   571 AKEYVRKASVEWYLNDVLLPVNGNSGLRISRNRKGS-----LIIRQVGPDNTGEYRCRVTVDGRE 630

  Fly   263 DVASVRVHVL-------NVRAIISGE----------------------HPEAMQT-GSSGCQYNW 297
            :.||..:.::       .|||.:..|                      |...|:| |.:|...:|
Worm   631 ENASAMLQIIEKPAMPERVRAELHNETMPAKVRVRWNEGFDGNEPIIKHAIEMRTMGPTGLWSDW 695

  Fly   298 LTIVLLL----GLVLCY-----------------SSQQCSSAVPASLTSSLPLPSQLPLPAAAAA 341
            .|.:..:    |...|:                 :|.:.....|:..:.|:.:|.| | |:||..
Worm   696 TTAIDNIPKEEGKPCCWTDIEDLRPSSTAEFRVVASNKHGPGKPSLPSYSVTMPQQ-P-PSAAPR 758

  Fly   342 TTTATGESASSESV 355
            ...|:..|..|..|
Worm   759 NVAASARSPHSVMV 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr6	NP_001287018.1	V-set	79..174	CDD:284989	20/95 (21%)
		IG_like	80..175	CDD:214653	20/95 (21%)
		IG_like	184..271	CDD:214653	17/89 (19%)
		IGc2	191..262	CDD:197706	14/73 (19%)
rig-4	NP_501339.2	IG_like	330..402	CDD:214653
		IGc2	338..393	CDD:197706
		I-set	459..543	CDD:254352	21/100 (21%)
		IGc2	478..534	CDD:197706	14/69 (20%)
		IG_like	553..639	CDD:214653	17/90 (19%)
		Ig	564..635	CDD:143165	14/75 (19%)
		FN3	643..747	CDD:238020	16/103 (16%)
		FN3	756..850	CDD:238020	5/17 (29%)
		FN3	858..954	CDD:238020
		FN3	959..1042	CDD:238020
		FN3	1057..1151	CDD:238020
		FN3	1156..1251	CDD:238020
		FN3	1258..1356	CDD:238020
		FN3	1361..1453	CDD:238020
		FN3	1464..1560	CDD:238020
		FN3	1572..1664	CDD:238020
		FN3	1679..1764	CDD:238020
		FN3	1774..1858	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810