DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY2 and TkR86C

DIOPT Version :9

Sequence 1:	NP_002555.4	Gene:	P2RY2 / 5029	HGNCID:	8541	Length:	377	Species:	Homo sapiens
Sequence 2:	NP_001097741.1	Gene:	TkR86C / 41286	FlyBaseID:	FBgn0004841	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	314	Identity:	68/314 - (21%)
Similarity:	137/314 - (43%)	Gaps:	37/314 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    25 CRFNEDFKYVLLP--------VSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDAL 81
            |.|....:...||        :.:|::....:..|.:.|:|..........:..::.:|:::|.|
  Fly    67 CLFPSPTRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLL 131

Human    82 YAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGR 146
            .::...:..:.:.....|||.::.|.:..|:....:..|:..|..||..|.:.::.||:  |...
  Fly   132 MSSLNCVFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLK--RRTS 194

Human   147 ARYARRVAGAVWVLVLACQAPVLYFVTTSAR-----GGRVTCH----DTSAPELFSRFVAYSSVM 202
            .|..|.:...:|.|.....||.|.:.:...:     ..|..|.    |...|...:.: ||:.::
  Fly   195 RRKVRIILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADY-AYNLII 258

Human   203 LGLLFAVPFAVILVCYVLMARRLLKPAYGTSG---------GLPRAKRKSVRTIAVVLAVFALCF 258
            |.|.:.:|..|:|:||.||.|.|    :|:..         ...::|||.||....::::||:|:
  Fly   259 LVLTYGIPMIVMLICYSLMGRVL----WGSRSIGENTDRQMESMKSKRKVVRMFIAIVSIFAICW 319

Human   259 LPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQR 312
            ||:|    |::.:...:....:...:...|.....||.:|:.::|::|:...:|
  Fly   320 LPYH----LFFIYAYHNNQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKR 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY2	NP_002555.4	7tmA_P2Y2	34..317	CDD:320495	66/305 (22%)
		TM helix 1	34..61	CDD:320495	6/34 (18%)
		TM helix 2	68..93	CDD:320495	3/24 (13%)
		TM helix 3	106..136	CDD:320495	7/29 (24%)
		TM helix 4	148..170	CDD:320495	6/21 (29%)
		TM helix 5	195..224	CDD:320495	11/28 (39%)
		TM helix 6	238..268	CDD:320495	11/29 (38%)
		TM helix 7	285..310	CDD:320495	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..377
TkR86C	NP_001097741.1	7tm_4	92..376	CDD:304433	63/289 (22%)
TkR86C	NP_001097741.1	7tm_1	100..363	CDD:278431	61/273 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910