DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY1 and 5-HT7

DIOPT Version :9

Sequence 1:	NP_002554.1	Gene:	P2RY1 / 5028	HGNCID:	8539	Length:	373	Species:	Homo sapiens
Sequence 2:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	86/435 - (19%)
Similarity:	150/435 - (34%)	Gaps:	143/435 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    11 NGTDAAFLAGPGSSWGNSTVASTAAVS-SSFKCALTKTGFQFYYLP-------AVYILVFIIG-F 66
            |.:..|.::..|.:..|...::|..|. |.....|.:.....:.||       ::.:|:.|:| .
  Fly   113 NSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTV 177

Human    67 LGN---SVAIWMFVFHMKPWSGISVYMFNLALADF-LYVLTLP-ALIFYYFNKTDWIFGDAMCKL 126
            :||   .:|:.|.....:|.:.:.|   :|||:|. :.:|.:| ||::....|  |.||..:|.:
  Fly   178 VGNVLVCIAVCMVRKLRRPCNYLLV---SLALSDLCVALLVMPMALLYEVLEK--WNFGPLLCDI 237

Human   127 QRFIFHVNLYGSILFLTCISAHRYSGVVYPLK-SLGRLKKKNAICISVLVWLIVV-VAISPILFY 189
            ......:....|||.|..||..||..:..||: .:.|..::..:|:.: |||... :::.|:|..
  Fly   238 WVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGI-VWLAAACISLPPLLIL 301

Human   190 SGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRA----------- 243
            ......:.....|  |....     |.|.:..|:..|.:||.::|..|..|.||
  Fly   302 GNEHEDEEGQPIC--TVCQN-----FAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRA 359

Human   244 -------------------------------------------LIYK------------------ 247
                                                       |.|.
  Fly   360 QTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSG 424

Human   248 -------DLDNSPLRRKSIYLVI----------IVLTVFAVSYIPFHVMKTMNLRARLDFQTPAM 295
                   .|..||..:|..:.:.          |:::.|.|.::||.::..:
  Fly   425 GGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALI------------- 476

Human   296 CAFNDRVYATYQVTRGLASL-------NSCVDPILYFLAGDTFRR 333
                 |.:.|..|...|:||       ||.::||:|......||:
  Fly   477 -----RPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY1	NP_002554.1	7tmA_P2Y1	52..335	CDD:320499	78/393 (20%)
		TM helix 1	52..79	CDD:320499	9/37 (24%)
		TM helix 2	86..111	CDD:320499	9/26 (35%)
		TM helix 3	124..154	CDD:320499	9/29 (31%)
		TM helix 4	166..188	CDD:320499	5/22 (23%)
		TM helix 5	214..243	CDD:320499	9/28 (32%)
		TM helix 6	253..283	CDD:320499	7/39 (18%)
		TM helix 7	303..328	CDD:320499	10/31 (32%)
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	47/181 (26%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	70/358 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910