DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment P2RY1 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_002554.1	Gene:	P2RY1 / 5028	HGNCID:	8539	Length:	373	Species:	Homo sapiens
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	91/382 - (23%)
Similarity:	158/382 - (41%)	Gaps:	29/382 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    11 NGTDAAFLAGPGSSW--GNSTVASTAAVSSS-----FKCALTKTGFQFYYLPAVYILVFIIGFLG 68
            |..::.:.......|  |:||:....::..:     ..|..|:..|...:...:|..|.|||..|
  Fly    30 NTNESLYTTELNHRWISGSSTIQPEESLYGTDLPTYQHCIATRNSFADLFTVVLYGFVCIIGLFG 94

Human    69 NSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHV 133
            |::.|::.:...|..:..::|:.|||:||..:::.:|.|: |......|.||:.|||.......:
  Fly    95 NTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGIPFLL-YTMRICSWRFGEFMCKAYMVSTSI 158

Human   134 NLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGT-----G 193
            ..:.|.:||..:||.||..|.:|:.|........|..:|.:.|....|.:.|::.|:.|     |
  Fly   159 TSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLMLPVILYASTVEQEDG 223

Human   194 VRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALI-------YKDLDN 251
            :..:..|...|........::.:|   |....|..||..||..|.|::|.|.       .|..:.
  Fly   224 INYSCNIMWPDAYKKHSGTTFILY---TFFLGFATPLCFILSFYYLVIRKLRSVGPKPGTKSKEK 285

Human   252 SPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLN 316
            ....||...||:.|::|:.:.::|..:.     :..|....||....:......:.:...|...|
  Fly   286 RRAHRKVTRLVLTVISVYILCWLPHWIS-----QVALIHSNPAQRDLSRLEILIFLLLGALVYSN 345

Human   317 SCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL 373
            |.|:||||....:.||:...:|. ....:.:.|.|.:.|..........|:.|...|
  Fly   346 SAVNPILYAFLSENFRKSFFKAF-TCMNKQDINAQLQLEPSVFTKQGSKKRGGSKRL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY1	NP_002554.1	7tmA_P2Y1	52..335	CDD:320499	76/294 (26%)
		TM helix 1	52..79	CDD:320499	8/26 (31%)
		TM helix 2	86..111	CDD:320499	8/24 (33%)
		TM helix 3	124..154	CDD:320499	9/29 (31%)
		TM helix 4	166..188	CDD:320499	5/21 (24%)
		TM helix 5	214..243	CDD:320499	9/28 (32%)
		TM helix 6	253..283	CDD:320499	7/29 (24%)
		TM helix 7	303..328	CDD:320499	8/24 (33%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	74/288 (26%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	67/267 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910