DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY1 and Octbeta3R

DIOPT Version :9

Sequence 1:	NP_002554.1	Gene:	P2RY1 / 5028	HGNCID:	8539	Length:	373	Species:	Homo sapiens
Sequence 2:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster

Alignment Length:	341	Identity:	74/341 - (21%)
Similarity:	136/341 - (39%)	Gaps:	78/341 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    13 TDAAF----LAGPGSSWGNSTVA--STAAVSSSF--KCALTKTGFQFYYLPAVYILVFIIGFLGN 69
            :|:.|    ..||..:...|.:|  :.|.:..|:  ...|...||       ::..:.:...|||
  Fly   100 SDSTFELLSTVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGF-------IFSSIILAAVLGN 157

Human    70 SVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKT------DWIFGDAMCKLQR 128
            ::.|.....:.|.....:.::.:||:||.|.     ||....||.:      .|:||..||.:..
  Fly   158 ALVIISVQRNRKLRVITNYFVVSLAMADMLV-----ALCAMTFNASVELSGGKWMFGPFMCNVYN 217

Human   129 FIFHVNLY---GSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLI-VVVAISPIL-- 187
               .:::|   .|||.|.|||..||..:|.||:....:..|....:...||:: .:::.:||.
  Fly   218 ---SLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLG 279

Human   188 FYSGTGVRKNKTITCYDTTSDEYLR---------SYFI---YSMCTTVAMFCVPLVLILGCYGLI 240
            :|                |::|:||         |:.:   |::.::...|.:|.:::|..|..|
  Fly   280 WY----------------TTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRI 328

Human   241 VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYAT 305
            .:..|.:   ...|.|.|..:::..:          |:..|.. ...|.:..|:.|..| ...|.
  Fly   329 FKEAIRQ---RKALSRTSSNILLNSV----------HMGHTQQ-PTSLSYLHPSDCDLN-ATSAR 378

Human   306 YQVTRGLASLNSCVDP 321
            .:....|::|...:.|
  Fly   379 EETHSALSNLEDMLQP 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY1	NP_002554.1	7tmA_P2Y1	52..335	CDD:320499	63/294 (21%)
		TM helix 1	52..79	CDD:320499	4/26 (15%)
		TM helix 2	86..111	CDD:320499	7/24 (29%)
		TM helix 3	124..154	CDD:320499	11/32 (34%)
		TM helix 4	166..188	CDD:320499	5/24 (21%)
		TM helix 5	214..243	CDD:320499	6/31 (19%)
		TM helix 6	253..283	CDD:320499	5/29 (17%)
		TM helix 7	303..328	CDD:320499	4/19 (21%)
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	53/226 (23%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	51/214 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910