DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment P2RY1 and AkhR

DIOPT Version :9

Sequence 1:	NP_002554.1	Gene:	P2RY1 / 5028	HGNCID:	8539	Length:	373	Species:	Homo sapiens
Sequence 2:	NP_995639.1	Gene:	AkhR / 33942	FlyBaseID:	FBgn0025595	Length:	455	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	94/385 - (24%)
Similarity:	160/385 - (41%)	Gaps:	81/385 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    23 SSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFV-FHMKPWSGI 86
            |:|.|  |..|.......|..:...|.:...  .||.::|:|..:|||..:::.. ..::....|
  Fly    14 SNWSN--VNDTNGTIHLTKDMVFNDGHRLSI--TVYSILFVISTIGNSTVLYLLTKRRLRGPLRI 74

Human    87 SVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYS 151
            .:.:.:||:||.:..|.|..:...:.....|:..|.||:|..|.....||.|...:.|||..||.
  Fly    75 DIMLMHLAIADLMVTLLLMPMEIVWAWTVQWLSTDLMCRLMSFFRVFGLYLSSYVMVCISLDRYF 139

Human   152 GVVYPLK---SLGRLKKKNAICISVLVWLIVVVAISP--ILFY-----SGTGVRKNKTITCYDTT 206
            .::.|||   :.||:       :....||..||...|  .||:     :.||..:......:.:.
  Fly   140 AILKPLKRSYNRGRI-------MLACAWLGSVVCSIPQAFLFHLEEHPAVTGYFQCVIFNSFRSD 197

Human   207 SDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRAL------IYKDLDNSPLRR--------- 256
            .||.|  |...|||   :|:..||::.:.|||.|...:      :.||:.....||
  Fly   198 FDEKL--YQAASMC---SMYAFPLIMFIYCYGAIYLEIYRKSQRVLKDVIAERFRRSNDDVLSRA 257

Human   257 --KSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQT---------PAMCAFNDRVYATYQVTR 310
              :::.:.|.::.||.:.:.|::   |:::...||..:         .|:..|
  Fly   258 KKRTLKMTITIVIVFIICWTPYY---TISMWYWLDKHSAGKINPLLRKALFIF------------ 307

Human   311 GLASLNSCVDPILYFLAGDTFRRRL--------SRATRKASRRSEANLQSKSEDMTLNIL 362
              ||.|||::|::|.|.  ..|.|:        :|.|..::|...:| |...:.:|.|.|
  Fly   308 --ASTNSCMNPLVYGLY--NIRGRMNNNNPSVNNRHTSLSNRLDSSN-QLMQKQLTNNSL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
P2RY1	NP_002554.1	7tmA_P2Y1	52..335	CDD:320499	78/319 (24%)
		TM helix 1	52..79	CDD:320499	7/27 (26%)
		TM helix 2	86..111	CDD:320499	7/24 (29%)
		TM helix 3	124..154	CDD:320499	11/29 (38%)
		TM helix 4	166..188	CDD:320499	5/23 (22%)
		TM helix 5	214..243	CDD:320499	11/28 (39%)
		TM helix 6	253..283	CDD:320499	7/40 (18%)
		TM helix 7	303..328	CDD:320499	8/24 (33%)
AkhR	NP_995639.1	7tm_1	55..319	CDD:278431	71/292 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910