DRSC/TRiP Functional Genomics Resources

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Protein Alignment P2RY1 and npr-17

DIOPT Version :9

Sequence 1:NP_002554.1 Gene:P2RY1 / 5028 HGNCID:8539 Length:373 Species:Homo sapiens
Sequence 2:NP_498743.2 Gene:npr-17 / 176124 WormBaseID:WBGene00015559 Length:436 Species:Caenorhabditis elegans


Alignment Length:351 Identity:86/351 - (24%)
Similarity:145/351 - (41%) Gaps:62/351 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    58 YILVFIIGFLGNSVAIWMFVFHMKPWSGIS-----VYMFNLALADFLYVLTLPALIFYYFNKTD- 116
            |:|:|::|..|| ||:...::|:...|..:     :|:..|:..||...|:||..:.      | 
 Worm    61 YLLLFLLGTCGN-VAVLTTIYHVIRSSRATLDNTLIYVIVLSCVDFGVCLSLPITVI------DQ 118

Human   117 ----WIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKN-AICISVLVW 176
                |:||...|||.....:.....|.|.||.:|..||:||.:|.:.  ||:.:| ||.|.:::.
 Worm   119 ILGFWMFGKIPCKLHAVFENFGKILSALILTAMSFDRYAGVCHPQRK--RLRSRNFAITILLVLA 181

Human   177 LIVVVAISPILFYSGTG--------------VRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFC 227
            :...:.:.|:| :|.|.              :.:.|...|......:...::.||..   :..:|
 Worm   182 VYAFITLCPLL-WSFTAREIILYAKETAPGMLTRMKIEKCTVDIDSQMFTAFTIYQF---ILCYC 242

Human   228 VPLVLILGCYGLIVRAL-----IYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKT-----M 282
            .|||||...|..::..|     .:|. ...|....|:|.:.:....| :.:.||. |.|     :
 Worm   243 TPLVLIAFFYTKLLSKLREHTRTFKS-SQIPFLHISLYTLAVACFYF-LCWTPFW-MATLFAVYL 304

Human   283 NLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILY-FLAG---DTFRRRLSRATRKAS 343
            ...|......|..      ||..|.: ..|...||.::.||| .|.|   ..:|...|.:|:|.:
 Worm   305 ENSANSSSVPPVF------VYIMYFI-HALPFTNSAINWILYGALNGQLQQRYRSNRSNSTKKTT 362

Human   344 RRSEANLQSKSEDMTLNILPEFKQNG 369
            ..:.:....:.:...||....::.||
 Worm   363 TTTASTALLEKKITNLNTNSNYQVNG 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
P2RY1NP_002554.1 7tmA_P2Y1 52..335 CDD:320499 79/315 (25%)
TM helix 1 52..79 CDD:320499 8/20 (40%)
TM helix 2 86..111 CDD:320499 7/29 (24%)
TM helix 3 124..154 CDD:320499 11/29 (38%)
TM helix 4 166..188 CDD:320499 5/22 (23%)
TM helix 5 214..243 CDD:320499 9/28 (32%)
TM helix 6 253..283 CDD:320499 8/34 (24%)
TM helix 7 303..328 CDD:320499 9/25 (36%)
npr-17NP_498743.2 7tm_4 61..>191 CDD:304433 40/138 (29%)
7tm_1 71..339 CDD:278431 70/290 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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