DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prosap and SHANK3

DIOPT Version :10

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:NP_001358973.1 Gene:SHANK3 / 85358 HGNCID:14294 Length:1806 Species:Homo sapiens


Alignment Length:2075 Identity:535/2075 - (25%)
Similarity:783/2075 - (37%) Gaps:703/2075 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PPPEPRDGW-------LLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFA 68
            |.|.|..|.       ::||:.:|:|...|||:......||..||:||.:|...|:::.|||||.
Human    68 PGPGPGAGMDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQ 132

  Fly    69 PPANGKAGKFLDEERRLGDYPFN--GPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRFLEC 131
            ||:.|:|||||||||.|.:||.|  .|:.|||.:||||||....:|::|...|||:|||::|::.
Human   133 PPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDY 197

  Fly   132 INGGHVEKIAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTAL 196
            :.....:|:|::..||||||||..:||:.||::|........||..|.||||.||:||:||.||:
Human   198 VQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAV 262

  Fly   197 HRAVEHDSLEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWN 261
            |.|....:..|::|||:|||||:|:|.||:||||.|.....:|...|.||||||.|||.|..||.
Human   263 HCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQ 327

  Fly   262 EVHQACRHGLVQHLEHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQ 326
            |:|||||.|.||||||||||||||..:|||||:.||:||:.|||:|||:||||||.|..:|:.:|
Human   328 EIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQ 392

  Fly   327 TPYQVAVIAGNLELAEIIENYKSEDIVPFRGPPRYNPKRR----SGIG-----WLSAN--GAAGA 380
            |.:|||:||||.||||:|:.:|..|:||||..|.|..:||    ||:.     ..||:  ...|.
Human   393 TAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGE 457

  Fly   381 ALLAAAGG-----------------------------GFGGAMVGSNGAAN-GNNGAGGVGLMLS 415
            |..||:.|                             ...|.:.|..|.:. ..:|.||.|    
Human   458 AQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISPSGPGGPG---- 518

  Fly   416 HQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHG-------PPSPCPSEHMLGAY 473
                                                    ...|       ||:|.|.......|
Human   519 ----------------------------------------PAPGPGPAPPAPPAPPPRGPKRKLY 543

  Fly   474 SSASSSLSEGSSGHRSHEDDISIVTDKSLGDTSDIISDSSGVGTNSDSAACSIGHPSTTVVCMEP 538
            |:.                                                    |....:.::.
Human   544 SAV----------------------------------------------------PGRKFIAVKA 556

  Fly   539 YAGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKHITNVMTASTG 603
            ::....|.|.|..|:.::|:...:.|..||.|:|  ::|:||||||:||.:|| |.|.       
Human   557 HSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKG--RTGWFPADCVEEVQMRQ-HDTR------- 611

  Fly   604 MAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQPLES 668
              |:.::.:                            :..|.:                      
Human   612 --PETREDR----------------------------TKRLFR---------------------- 624

  Fly   669 NEGGASGNGINNRNNNHSVGQYSSATAPRIKKSAY--NAPRSVVLHRAKRGFGFILRGAKASSQL 731
                           :::||.|.|.|:    .|.|  :...:|:..|...||||:||||||.:.:
Human   625 ---------------HYTVGSYDSLTS----HSDYVIDDKVAVLQKRDHEGFGFVLRGAKAETPI 670

  Fly   732 MQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLT 796
            .:..|:..|||||||:.||..|||..||||.||||:.:||.:|....|:|||.:||..|..:.:.
Human   671 EEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMK 735

  Fly   797 VVSPQFPHQMQASAQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSV 861
            |||                                         :.||          ....|:.
Human   736 VVS-----------------------------------------VTRK----------PEEDGAR 749

  Fly   862 RMAPMPPRRDPKTTLSVGRARAKSMVAGLE-------NGGEKEDDLPHTKSNSVESIATPTPTGI 919
            |.||.||:|.|.|||::   |:|||.|.||       ..|||.|::       :.:.|.||    
Human   750 RRAPPPPKRAPSTTLTL---RSKSMTAELEELASIRRRKGEKLDEM-------LAAAAEPT---- 800

  Fly   920 QTGPG-TPVQLRTASIKARPTSSRITAAELEELFQRQQGEG----------------SAANASRY 967
             ..|. .....|.|::|.||||.|||.||:..||:||...|                |.....:.
Human   801 -LRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKL 864

  Fly   968 ATMMTSSRFQSGT-------DSGAATPPASNGSPMRSGPLVYGSVAEMKRKTARSKHGSGTLRGK 1025
            |::: ..||...|       :.....||.....|....|..:.|                   |.
Human   865 ASLL-EGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDS-------------------GP 909

  Fly  1026 PVA-TPTVGPGGAGGGRDLKRFHSTPDLHGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRL- 1088
            |.| :|...||.|   .|..|....|.|.. :|...|:.:::..              |:|..| 
Human   910 PPAFSPPPPPGRA---YDTVRSSFKPGLEA-RLGAGAAGLYEPG--------------AALGPLP 956

  Fly  1089 -NSNQGELKLGGLGAGSATGAGGAVLPPPNHPPPPPPVGQVVKVETRSSVSEYESTISLQQKLKK 1152
             ...|...:...:...||..:|.|..|||...||..|                          |:
Human   957 YPERQKRARSMIILQDSAPESGDAPRPPPAATPPERP--------------------------KR 995

  Fly  1153 RTENDAVTSAAIDGVQSSFNPSAN-----AKIYA--SPQELRNVMAWKLRQAQEKPSQETSA--- 1207
            |.......|           |.||     |.::|  .||..::.:   ::|.|.:.:||.:|   
Human   996 RPRPPGPDS-----------PYANLGAFSASLFAPSKPQRRKSPL---VKQLQVEDAQERAALAV 1046

  Fly  1208 GSQQP----VSQYAAPTQM--RPAQQQQQAQQPPTALASHYAAPQVQVQQVQQVQQS----PQQS 1262
            ||..|    .::..:||..  ||......|...| .||.....| .:.:::::.::|    ...:
Human  1047 GSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGP-GLAFGGPGP-AKDRRLEERRRSTVFLSVGA 1109

  Fly  1263 APQSPPAPPLPQAAPVPAQNGN--GNGSTSGAGSAPPIP----EPDYSCSESDGEDENSI---LV 1318
            ...|.|...||...|..:.:..  |.|.|:|.....|.|    :|..| ..|.|...::.   |.
Human  1110 IEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALKPLVS-GPSLGPSGSTFIHPLT 1173

  Fly  1319 ARNTKLNEKIALFDVPETSGNSQASGSSSNSGSASISHS----------LSVEEIQRIRSNLKTS 1373
            .:....:..:||    ..:...:|..|.:.|.|.:..||          :.|:.....|.:|.:.
Human  1174 GKPLDPSSPLAL----ALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDPERGSLASP 1234

  Fly  1374 KSSPNGFA-----------KKPEEEKPQQEQQQSH---------QQPQQLL---------QP--- 1406
            ..||...|           |.|.||:...|.::|.         |:|..|:         :|   
Human  1235 AFSPRSPAWIPVPARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRL 1299

  Fly  1407 --GEDECDNSSSGVSSEQEQLALAAGV----TLPGGGKPTDTIKKKPSVTIVEEPKTI------P 1459
              .|:|...:.....:..:..|:|..:    ..|.||.|.|....:.|..  |||:.:      |
Human  1300 GGAEEERPGTPELAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSE--EEPELVFAVNLPP 1362

  Fly  1460 DQPSSNTSHTTKPMAKTTI---------------SIGGGGSAVPTATLTVKQLVQQQHAPVIQQQ 1509
            .|.||:...|.:.:|:..:               .:.|.|.: ||...:..........|...:.
Human  1363 AQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPS-PTTVPSPASGKPSSEPPPAPES 1426

  Fly  1510 QQQLGSKQPVTAASTNKFTQQSNINSNVMSPQVL----GRIPSHH------H----QQQSSNPNQ 1560
            ....|.::..|.:|::...:.::..|.|.|...|    |.:...|      |    ::....|..
Human  1427 AADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKP 1491

  Fly  1561 KL--------IATQQQILQQ-QQQQLAHQQHLQQILKAKAAAAGGASNTAVLVAKHQQKLHKGTS 1616
            ||        :..:..:|:| ...:|..|||       .||:||.||                 :
Human  1492 KLKSPLGKGPVTFRDPLLKQSSDSELMAQQH-------HAASAGLAS-----------------A 1532

  Fly  1617 SGHESEMETRSDLEDDDGDLSPSPPAKAFQRHNSLTRKQAAAIAMQRGATRTTAVSLMQLPPPLE 1681
            :|                   |:.|...|||.:.|......:    ||           ||.|  
Human  1533 AG-------------------PARPRYLFQRRSKLWGDPVES----RG-----------LPGP-- 1561

  Fly  1682 ADSDGEPSQLTLQRQQSHHPSQTHPHPHQLQQQLQLQQQQQQQQQQQQPMAAHIVGMLPS----- 1741
              .|.:|:.::                       :|..:.||..:..:.:....||.|.|     
Human  1562 --EDDKPTVIS-----------------------ELSSRLQQLNKDTRSLGEEPVGGLGSLLDPA 1601

  Fly  1742 --------------GQLVAVASGAVAGVPGVGATAVQQGNNNLQQLCTDNLVLAPPPQFCDCNDA 1792
                          |:|.::::....|.||.||                :..:.|..::   ..|
Human  1602 KKSPIAAARLFSSLGELSSISAQRSPGGPGGGA----------------SYSVRPSGRY---PVA 1647

  Fly  1793 KHAPQPHLPTSQYHPQQQQQQQHQQQQQQQQQLQQQLQQQQMLQMHQRLSG-GAGAGAVG 1851
            :.||.|..|.|.                                  :|:.| |||||..|
Human  1648 RRAPSPVKPASL----------------------------------ERVEGLGAGAGGAG 1673

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_F0_SHANK 20..103 CDD:340611 41/84 (49%)
ANKYR 109..348 CDD:440430 131/238 (55%)
ANK repeat 157..189 CDD:293786 14/31 (45%)
ANK repeat 191..222 CDD:293786 16/30 (53%)
ANK repeat 224..289 CDD:293786 42/64 (66%)
ANK repeat 291..322 CDD:293786 20/30 (67%)
ANK repeat 324..353 CDD:293786 16/28 (57%)
SH3 532..586 CDD:473055 17/53 (32%)
PDZ_SHANK1_3-like 703..800 CDD:467228 46/98 (47%)
SHANK3NP_001358973.1 Intramolecular interaction with the ANK repeats. /evidence=ECO:0000250 76..150 32/73 (44%)
FERM_F0_SHANK3 83..169 CDD:340697 41/85 (48%)
ANKYR 155..408 CDD:440430 139/252 (55%)
ANK repeat 223..255 CDD:293786 14/31 (45%)
ANK 1 223..253 13/29 (45%)
ANK repeat 257..288 CDD:293786 16/30 (53%)
ANK 2 257..286 15/28 (54%)
ANK repeat 290..355 CDD:293786 42/64 (66%)
ANK 3 290..320 16/29 (55%)
ANK 4 324..353 23/28 (82%)
ANK repeat 357..388 CDD:293786 20/30 (67%)
ANK 5 357..386 20/28 (71%)
ANK 6 390..420 16/29 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..467 22/59 (37%)
SH3_Shank3 549..600 CDD:212917 15/52 (29%)
PDZ_SHANK1_3-like 639..740 CDD:467228 47/141 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..689 10/23 (43%)
Required for interaction with ABI1. /evidence=ECO:0000250 753..760 4/6 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 760..853 36/107 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 871..1021 43/223 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1115..1460 69/352 (20%)
PRK12323 <1208..>1412 CDD:481241 40/206 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1475..1525 10/56 (18%)
SH3-binding. /evidence=ECO:0000255 1485..1491 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1546..1584 11/79 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1627..1664 13/89 (15%)
SAM_Shank1,2,3 1739..1804 CDD:188905
Blue background indicates that the domain is not in the aligned region.

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