DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prosap and Shank1

DIOPT Version :9

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:NP_113939.2 Gene:Shank1 / 78957 RGDID:621011 Length:2167 Species:Rattus norvegicus


Alignment Length:2000 Identity:505/2000 - (25%)
Similarity:750/2000 - (37%) Gaps:597/2000 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 PPEPRDGWLLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAG 76
            |.:.....::.||.:|:|:..|||:|..:..:|..|||||.:|.:.|::..|||||.|..:|:..
  Rat    65 PDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDA 129

  Fly    77 KFLDEERRLGDYP--FNGPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEK 139
            .||:|||.|.:||  |...|.|||.:||.||||...|||:||..|||:..|::|||.:..|..:|
  Rat   130 NFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDK 194

  Fly   140 IAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDS 204
            :|::..||||||:|.|:||:||||:|...:...:::..|..|||.:|:|.:||.||||:|.....
  Rat   195 VARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARH 259

  Fly   205 LEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRH 269
            ..|::.||:||.||||:|.||:|||:.:.....:.:..|.||::.|.|||.|..||.|:||||:.
  Rat   260 CLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLYNRAQLGIADENGWQEIHQACQR 324

  Fly   270 GLVQHLEHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVI 334
            |..|||||||||||:...:|||||:.||:||:.|:|.|||:||:|||.:..:|...|||:|||||
  Rat   325 GHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGANKDVKNNNGQTPFQVAVI 389

  Fly   335 AGNLELAEIIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNG 399
            |||.||.|:|.|::.:|:|||:..|:|..:||         |..||.|....      |::.:|.
  Rat   390 AGNFELGELIRNHREQDVVPFQESPKYAARRR---------GPPGAGLTVPP------ALLRANS 439

  Fly   400 ------------AANGNNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHL 452
                        :|.|.:.:|..|.....|...|..|                            
  Rat   440 DTSMALPDWMVFSAPGASSSGTPGPTSGPQGQSQPSA---------------------------- 476

  Fly   453 HTLQLHGPPSPCPSEHMLGAYSSASSSLSEGSSGHRSHED----------DISIVTDKSLGDTSD 507
                    ||...|...|.:.||...:.:...|..|..||          ......|...|.|..
  Rat   477 --------PSTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPRDGPAGGTGG 533

  Fly   508 IISDSSGVGTNSDSAACSIGHPSTTVVCMEPYAGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRG 572
            .......:|:...........|..:.:.::.|.....|.|.|..|:.|:|:...:.|..||.|:|
  Rat   534 SGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQGEGEISLSKGEKIKVLSIGEGGFWEGQVKG 598

  Fly   573 TNQSGFFPADCVQEVSLRQKHITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGH 637
              :.|:||:||::||:.|.               |:.:|:                       ..
  Rat   599 --RVGWFPSDCLEEVANRS---------------QEGRQE-----------------------SR 623

  Fly   638 SGSSSTLLQQPHQSPSLSVASNGSCQQPLESNEGGASGNGINNRNNNHSVGQYSSATAPRI---- 698
            |..:..|.:                                     :::||.|.|..||.:    
  Rat   624 SDKAKRLFR-------------------------------------HYTVGSYDSFDAPSLIDGI 651

  Fly   699 -KKSAYNAPRSVVLHRAK--RGFGFILRGAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGL 760
             ..|.|......||.:.|  .||||:||||||.:.:.:..|:..|||||||:.||.||||..|||
  Rat   652 DSGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGL 716

  Fly   761 RPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQASAQYLPSGARAGSHHLN 825
            |.||||:.:||::|....|.|||.|||..|..:.:.||.                        :.
  Rat   717 RMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVM------------------------VT 757

  Fly   826 SGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRR------DPKTTLSVGRARAK 884
            ..|...::.|::.:...:::..|..|....|....:.....|.::      .|....|:.:.|..
  Rat   758 RHPDMDEAVHKKASQQAKRLPPPAISLRSKSMTSELEEMVSPWKKKIEYEQQPAAVPSMEKKRTV 822

  Fly   885 SMVAGLENGGEKEDDLPHTKSNSVESIATPTPTGIQTGPGTPVQLRTASI-KARPTSSRITAAEL 948
            ..:|     ..|.|::......::.:..:|.|.|:            ||: |.||.....|.:..
  Rat   823 YQMA-----LNKLDEILAAAQQTISASESPGPGGL------------ASLGKHRPKGFFATESSF 870

  Fly   949 EE-------------------LFQRQQGEGSAANASRYAT--MMTSSRFQSGTDSGAATPPASNG 992
            :.                   |..||:..|:|.:...|..  .|..||..|...|....||.:..
  Rat   871 DPHHRSQPSYDRPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTS 935

  Fly   993 SPMRSGPLVYGSVAEMKRKTARSKHGSGTL----RGKPVATPTVGPGGA---------------G 1038
            .|            |....|..:...||.|    ||.|....:.||..|               |
  Rat   936 PP------------EPPYSTPPAPSSSGRLTPSPRGGPFNPSSGGPLPASSPSSFDGPSPPDTRG 988

  Fly  1039 GGRDLKRFHST---PDLHGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRLNSNQGELKLGGL 1100
            |||:...:||.   |..|.|..|             ||.       ||                 
  Rat   989 GGREKSLYHSAALPPAHHHPPHH-------------HHH-------HA----------------- 1016

  Fly  1101 GAGSATGAGGAVLPPPN------HPPPPPPVGQVVKVETRSSVSEYESTISL--QQKLKK-RTEN 1156
                         |||.      |||.||      ::||..|..:....::|  |..|:. |...
  Rat  1017 -------------PPPQPHHHHAHPPHPP------EMETGGSPDDPPPRLALGPQPSLRGWRGGG 1062

  Fly  1157 DAVTSAAIDGVQSSFNPSANAKIYASPQELRNVMAWKLRQAQEKPSQETSAGSQQPVSQYAAPTQ 1221
            .:.||.|         ||                          ||..:|:|..      :.|||
  Rat  1063 PSPTSGA---------PS--------------------------PSHHSSSGGS------SGPTQ 1086

  Fly  1222 MRPAQQQQQAQQPP-TALASHYA---------APQVQVQQVQQVQQSPQQSAPQSPPAPPLPQAA 1276
               |...:..|.|| .|.|:.|.         .|.|:..:|:...|.....:..||.:|.||::.
  Rat  1087 ---APALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGSIPSASSPTSPALPRSE 1148

  Fly  1277 PVPAQNGNGNGSTSGAGSAPPIPEPDYSCSESDGEDENSILVARNTKLNEKIALFDVPETSGNSQ 1341
            |.||          |......||.|             :|::             ..|.||.:.:
  Rat  1149 PPPA----------GPSEKNSIPIP-------------TIII-------------KAPSTSSSGR 1177

  Fly  1342 AS-GSSSNS-----------GSASISHSLSVEEIQRIRSNLKTSKSSPNGFAKKPEEEK------ 1388
            :| |||:.:           |.:|.|.:.:...:....|.:.| .:||:|.|......:      
  Rat  1178 SSQGSSTEAEPPTQPDGAGGGGSSPSPAPATSPVPPSPSPVPT-PASPSGPATLDFTSQFGAALV 1241

  Fly  1389 --PQQE---QQQSHQQPQQLLQPGEDECDNSSSGVSSEQEQLALAAGVTLPGGGKPTDTIKKKPS 1448
              .::|   |.::.::....|.....:.|...||               |..||.|...::...|
  Rat  1242 GAARREGGWQNEARRRSTLFLSTDAGDEDGGDSG---------------LGPGGPPGPRLRHSKS 1291

  Fly  1449 VTIVEEPKTIPDQP-----SSNTSHTTKPMAKTTISIGGGGSAVP-TATLTVKQLVQQQHAPVIQ 1507
            :    :......:|     |..:|......|..:.:.||.||:.. |:.|..:.||.......:.
  Rat  1292 I----DEGMFSAEPYLRLESGGSSGGYGAYAAGSRAYGGSGSSSAFTSFLPPRPLVHPLTGKALD 1352

  Fly  1508 QQQQQLGSKQPVTAASTNKFTQQSNINSNVMSPQVLGRIPS----------HHHQQQS-SNPNQK 1561
            .     .|...:..|:..:..::|:....  :||...|.||          |||...| .:|:  
  Rat  1353 P-----ASPLGLALAARERALKESSEGGG--TPQPPPRPPSPRYDAPPPTLHHHSPHSPHSPH-- 1408

  Fly  1562 LIATQQQILQ----QQQQQLAHQQHLQQILKAKAAA---------------AGGASNTAVLVAKH 1607
              |..:.:|:    ..:::|.::..|....||..|:               |.|.....:.:...
  Rat  1409 --ARHEPVLRLWGDPARRELGYRAGLGSQEKALTASPPAARRSLLHRLPPTAPGVGPLLLQLGPE 1471

  Fly  1608 QQKLHKGTSSG--------------HESEME----------TR-SDLEDDDGDLSPSPPAKAFQR 1647
            ....|.|.|..              |...:|          || |..||..|...|||       
  Rat  1472 PPTPHPGVSKAWRTAAPEEPERLPLHVRFLENCQARPPPAGTRGSSTEDGPGVPPPSP------- 1529

  Fly  1648 HNSLTRKQAAAIAMQRGATRTTAVSLMQLPPP---LEADSDGE---------PSQLTLQRQQSHH 1700
                .|....:....|| .....:.|:.||||   ::.| |||         |.:.:...::...
  Rat  1530 ----RRVLPTSPTSPRG-NEENGLPLLVLPPPAPSVDVD-DGEFLFAEPLPPPLEFSNSFEKPES 1588

  Fly  1701 PSQTHPHPHQLQQQLQLQQQQQQQQQQQQPMAAHIVGMLPSGQLVAVASGAVAGVPGV---GATA 1762
            |....| ||.|                ..|.:       |:..|.|....|||..|..   .|::
  Rat  1589 PLTPGP-PHPL----------------PDPPS-------PATPLPAAPPPAVAAAPPTLDSTASS 1629

  Fly  1763 VQQGNNNLQQLCTDNLVLAP--PPQFCDCNDAKHAPQPHLPTSQYHPQQQ 1810
            :...::.:..| |.....||  ||          ||.|..|.:...|..|
  Rat  1630 LTSYDSEVATL-TQGAPAAPGDPP----------APGPPAPAAPAPPAPQ 1668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_f0 20..103 CDD:293120 37/84 (44%)
Ank_2 128..222 CDD:289560 43/93 (46%)
ANK 131..233 CDD:238125 46/101 (46%)
ANK repeat 157..189 CDD:293786 12/31 (39%)
ANK 186..312 CDD:238125 65/125 (52%)
ANK repeat 191..222 CDD:293786 16/30 (53%)
Ank_2 196..322 CDD:289560 64/125 (51%)
ANK repeat 224..289 CDD:293786 32/64 (50%)
ANK repeat 291..322 CDD:293786 17/30 (57%)
ANK repeat 324..353 CDD:293786 17/28 (61%)
SH3 532..586 CDD:302595 17/53 (32%)
PDZ_signaling 706..798 CDD:238492 46/93 (49%)
Shank1NP_113939.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63
FERM_f0 73..156 CDD:293120 36/82 (44%)
Ank_2 187..277 CDD:289560 40/89 (45%)
ANK 1 195..210 8/14 (57%)
ANK 206..334 CDD:238125 59/127 (46%)
ANK 2 212..245 13/32 (41%)
ANK repeat 212..244 CDD:293786 12/31 (39%)
ANK 3 246..278 16/31 (52%)
ANK repeat 246..277 CDD:293786 16/30 (53%)
ANK 274..399 CDD:238125 69/124 (56%)
ANK 4 279..312 12/32 (38%)
ANK repeat 279..311 CDD:293786 12/31 (39%)
Ank_2 285..377 CDD:289560 46/91 (51%)
ANK 5 313..345 19/31 (61%)
ANK repeat 313..344 CDD:293786 19/30 (63%)
ANK 6 346..378 17/31 (55%)
ANK repeat 346..377 CDD:293786 17/30 (57%)
ANK 7 379..395 11/15 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 413..432 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 453..546 21/128 (16%)
SH3 557..608 CDD:302595 16/52 (31%)
PDZ_signaling 661..754 CDD:238492 46/92 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 841..894 10/64 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 917..1233 99/464 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1294 11/67 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1308..1417 25/119 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1429..1725 58/287 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1740..1787
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1842..1866
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1898..1988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2002..2029
SAM_Shank1,2,3 2100..2165 CDD:188905
SAM 2103..2167 CDD:197735
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342314
Domainoid 1 1.000 54 1.000 Domainoid score I10928
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 409 1.000 Inparanoid score I1814
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D133974at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46280
orthoMCL 1 0.900 - - OOG6_103134
Panther 1 1.100 - - LDO PTHR24135
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X750
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.900

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