DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prosap and Shank3

DIOPT Version :10

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:NP_067708.2 Gene:Shank3 / 59312 RGDID:69264 Length:1806 Species:Rattus norvegicus


Alignment Length:2083 Identity:527/2083 - (25%)
Similarity:774/2083 - (37%) Gaps:716/2083 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGSGAFDDEPPPEPRDGWLLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYG 65
            |.|.||           ..::||:.:|:|...|||:......||..||:||.:|...|:::.|||
  Rat    76 MDGPGA-----------SAVVVRVGIPDLQQTKCLRLDPTAPVWAAKQRVLCALNHSLQDALNYG 129

  Fly    66 LFAPPANGKAGKFLDEERRLGDYPFN--GPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRF 128
            ||.||:.|:|||||||||.|.|||.|  .|:.|||.:||||||....:|::|...|||:|||::|
  Rat   130 LFQPPSRGRAGKFLDEERLLQDYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKF 194

  Fly   129 LECINGGHVEKIAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGS 193
            ::.:.....:|:|::..||||||||..:||:.||::|........||..|.||||.||:||:||.
  Rat   195 MDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLRNGGAHLDFRTRDGL 259

  Fly   194 TALHRAVEHDSLEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQ 258
            ||:|.|....:..|::|||:|||||:|:|.||:||||.|.....:|...|.||||||.||..|..
  Rat   260 TAVHCATRQRNAGALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDEN 324

  Fly   259 GWNEVHQACRHGLVQHLEHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNF 323
            ||.|:|||||.|.||||||||||||:|..:|||||:.||:||:.|||:|||:||||||.:..:|:
  Rat   325 GWQEIHQACRFGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNY 389

  Fly   324 ANQTPYQVAVIAGNLELAEIIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGG 388
            .:||.:|||:||||.||||:|:.:|..|:||||..|.|..:||                      
  Rat   390 NSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRR---------------------- 432

  Fly   389 GFGGAMVGSNGAAN--------------GNNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQN 439
                 :.|.:|.|:              |:..|...|..|                         
  Rat   433 -----LAGPSGLASPRPLQRSASDINLKGDQPAASPGPTL------------------------- 467

  Fly   440 HHQQLQQQQLPHLHTLQLHGPPSPCPSEHMLGAYSSASSSLSEGSSGHRSHEDDISIVTDKSLGD 504
                   :.|||...||                      .|.|.....|..|.:           
  Rat   468 -------RSLPHQLLLQ----------------------RLQEEKDRDRDGEQE----------- 492

  Fly   505 TSDIISDSSGVGTNSDSAACSIGH------------------------------PSTTVVCMEPY 539
             :||...|:|.|.:|..:....|.                              |....:.::.:
  Rat   493 -NDISGPSAGRGGHSKISPSGPGGSGPAPGPGPASPAPPAPPPRGPKRKLYSAVPGRKFIAVKAH 556

  Fly   540 AGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQ---KHITNVMTAS 601
            :....|.|.|..|:.::|:...:.|..||.|:|  ::|:||||||:||.:||   :|.|      
  Rat   557 SPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKG--RTGWFPADCVEEVQMRQYDTRHET------ 613

  Fly   602 TGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQPL 666
                 ::.:.:.|.:                                                  
  Rat   614 -----REDRTKRLFR-------------------------------------------------- 623

  Fly   667 ESNEGGASGNGINNRNNNHSVGQYSSATAPRIKKSAYNAPRSVVL--HRAKRGFGFILRGAKASS 729
                             :::||.|.|.|:    .|.|.....|.:  .|...||||:||||||.:
  Rat   624 -----------------HYTVGSYDSLTS----HSDYVIDDKVAILQKRDHEGFGFVLRGAKAET 667

  Fly   730 QLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVN 794
            .:.:..|:..|||||||:.||..|||..||||.||||:.:||.:|....|:|||.:||..|..:.
  Rat   668 PIEEFTPTPAFPALQYLESVDVEGVAWKAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLV 732

  Fly   795 LTVVSPQFPHQMQASAQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGG 859
            :.|||                                         :.||        |...|  
  Rat   733 MKVVS-----------------------------------------VTRK--------PEEDS-- 746

  Fly   860 SVRMAPMPPRRDPKTTLSVGRARAKSMVAGLE-------NGGEKEDDLPHTKSNSVESIATPTPT 917
            :.|.||.||:|.|.|||::   |:|||.|.||       ..|||.|::       :...|.||  
  Rat   747 ARRRAPPPPKRAPSTTLTL---RSKSMTAELEELASIRRRKGEKLDEI-------LAVAAEPT-- 799

  Fly   918 GIQTGPG-TPVQLRTASIKARPTSSRITAAELEELFQRQQGEG----------------SAANAS 965
               ..|. .....|.|::|.||||.|||.||:..||:||...|                |.....
  Rat   800 ---LRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDE 861

  Fly   966 RYATMMTSSRFQSGT-------DSGAATPPASNGSPMRSGPLVYGSVAEMKRKTARSKHGSGTLR 1023
            :.|::: ..||...|       :.....||.....|....|..:.|                   
  Rat   862 KLASLL-EGRFPRSTSMQDTVREGRGIPPPPQTAPPPPPAPYYFDS------------------- 906

  Fly  1024 GKPVATPTVGPGGAGGGR--DLKRFHSTPDLHGPQLHGSASSIWQASGKGHHSQDDVATLHASL- 1085
            |.|   ||..|.....||  |..|....|.|.. :|...|:.::           |..|....| 
  Rat   907 GPP---PTFSPPPPPPGRAYDTVRSSFKPGLEA-RLGAGAAGLY-----------DSGTPLGPLP 956

  Fly  1086 --QRLNSNQGELKLGGLGAGSATGAGGAVLPPPNHPPPPPPVGQVVKVETRSSVSEYESTISLQQ 1148
              :|....:..:.|    ..||...|....|.|...||..|                        
  Rat   957 YPERQKRARSMIIL----QDSAPEVGDVPRPAPAATPPERP------------------------ 993

  Fly  1149 KLKKRTENDAVTSAAIDGVQSSFNPSAN-----AKIYA--SPQELRNVMAWKLRQAQEKPSQETS 1206
              |:|.......|           |.||     |.::|  .||..::.:   ::|.|.:.:||.:
  Rat   994 --KRRPRPSGPDS-----------PYANLGAFSASLFAPSKPQRRKSPL---VKQLQVEDAQERA 1042

  Fly  1207 A---GSQQPV----SQYAAPTQM--RPAQQQQQAQQPPTALASHYAAPQ---VQVQQVQQVQQS- 1258
            |   ||..||    ::..:||..  ||......:.:   .|...:..|.   |:.:::::.::| 
  Rat  1043 ALAVGSPGPVGGSFAREPSPTHRGPRPGGLDYSSGE---GLGLTFGGPSPGPVKERRLEERRRST 1104

  Fly  1259 ---PQQSAPQSPPAPPLPQAAPVPAQNGN--GNGSTSGAGSAPPIP---------EPDYSCSESD 1309
               ...:...|||:..||...|..:.:..  |.|:|:|.....|.|         .|....|   
  Rat  1105 VFLSVGAIEGSPPSADLPSLQPSRSIDERLLGTGATTGRDLLLPSPVSALKPLVGGPSLGPS--- 1166

  Fly  1310 GEDENSILVARNTKLNEKIALFDVPETSGNSQASGSSSNSGSASISHS----------LSVEEIQ 1364
            |......|..:....:..:||    ..:...:|..|.:.|.|.:..||          :.|:...
  Rat  1167 GSTFIHPLTGKPLDPSSPLAL----ALAARERALASQTPSRSPTPVHSPDADRPGPLFVDVQTRD 1227

  Fly  1365 RIRSNLKTSKSSPNGFAKKP-----EEEKPQQEQQQSHQQPQQLLQPGEDECDNSSSGV------ 1418
            ..|..|.:...||...|..|     |.|||.:|:::|.:..:.::....|......:|:      
  Rat  1228 SERGPLASPAFSPRSPAWIPVPARREAEKPTREERKSPEDKKSMILSVLDTSLQRPAGLIVVHAT 1292

  Fly  1419 SSEQEQLALAAGVTLPGG-------------GKPTDTIKKKPSVTI-----------VEEPKTI- 1458
            |:.||...|.|....||.             .:|..:.:.:|..:|           .|||:.: 
  Rat  1293 SNGQEPNRLGAEEERPGTPELAPTPMQAAAVAEPMPSPRAQPPGSIPADPGPGQGSSEEEPELVF 1357

  Fly  1459 -----PDQPSSNTSHTTKPMAKTTISIG------------------GGGSAVPTATLTVKQLVQQ 1500
                 |.|.||:...|.:.:|:    ||                  .|...:||...:.......
  Rat  1358 AVNLPPAQLSSSDEETREELAR----IGLVPPPEEFANGILLATPPPGPGPLPTTVPSPASGKPS 1418

  Fly  1501 QHAPVIQQQQQQLGSKQPVTAASTNKFTQQSNINSNVMSPQVL----GRIPSHH------H---- 1551
            ...|...:.....|.::..|.:|::...:.::..|.|.|...|    |.:...|      |    
  Rat  1419 SELPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLL 1483

  Fly  1552 QQQSSNPNQKL--------IATQQQILQQQQQQLAHQQHLQQILKAKAAAAGGASNTAVLVAKHQ 1608
            ::....|..||        :..:..:|:|                         |:.:.|:|:. 
  Rat  1484 EKPPVPPKPKLKSPLGKGPVTFRDPLLKQ-------------------------SSDSELMAQQ- 1522

  Fly  1609 QKLHKGTSSGHESEMETRSDLEDDDGDLSPSPPAKAFQRHNSLTRKQAAAIAMQRGATRTTAVSL 1673
               |..||:|..|.             ..|:.|...|||.:.|......:    ||         
  Rat  1523 ---HHATSTGLTSA-------------AGPARPRYLFQRRSKLWGDPVES----RG--------- 1558

  Fly  1674 MQLPPPLEADSDGEPSQLTLQRQQSHHPSQTHPHPHQLQQQLQLQQQQQQQQQQQQPMAAHIVGM 1738
              ||.|    .|.:|:.::                       :|..:.||..:..:.:....||.
  Rat  1559 --LPGP----EDDKPTVIS-----------------------ELSSRLQQLNKDTRSLGEEPVGG 1594

  Fly  1739 LPS-------------------GQLVAVASGAVAGVPGVGATAVQQGNNNLQQLCTDNLVLAPPP 1784
            |.|                   |:|..:::....|.||.||                :..:.|..
  Rat  1595 LGSLLDPAKKSPIAAARLFSSLGELSTISAQRSPGGPGGGA----------------SYSVRPSG 1643

  Fly  1785 QFCDCNDAKHAPQPHLPTSQYHPQQQQQQQHQQQQQQQQQLQQQLQQQQMLQMHQRLSG-GAGAG 1848
            ::   ..|:.||.|..|.|.                                  :|:.| |||.|
  Rat  1644 RY---PVARRAPSPVKPASL----------------------------------ERVEGLGAGVG 1671

  Fly  1849 AVG 1851
            ..|
  Rat  1672 GAG 1674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_F0_SHANK 20..103 CDD:340611 42/84 (50%)
ANKYR 109..348 CDD:440430 128/238 (54%)
ANK repeat 157..189 CDD:293786 14/31 (45%)
ANK repeat 191..222 CDD:293786 16/30 (53%)
ANK repeat 224..289 CDD:293786 40/64 (63%)
ANK repeat 291..322 CDD:293786 19/30 (63%)
ANK repeat 324..353 CDD:293786 16/28 (57%)
SH3 532..586 CDD:473055 17/53 (32%)
PDZ_SHANK1_3-like 703..800 CDD:467228 46/98 (47%)
Shank3NP_067708.2 Ubl1_cv_Nsp3_N-like 83..169 CDD:475130 42/85 (49%)
ANKYR 155..408 CDD:440430 136/252 (54%)
ANK repeat 222..255 CDD:293786 14/32 (44%)
ANK repeat 257..288 CDD:293786 16/30 (53%)
ANK repeat 290..355 CDD:293786 40/64 (63%)
ANK repeat 357..388 CDD:293786 19/30 (63%)
SH3 548..599 CDD:473055 15/52 (29%)
PDZ_SHANK1_3-like 638..739 CDD:467228 47/141 (33%)
Atrophin-1 1087..>1385 CDD:460830 63/308 (20%)
PRK12323 <1239..>1429 CDD:481241 37/193 (19%)
SAM_Shank1,2,3 1739..1804 CDD:188905
Blue background indicates that the domain is not in the aligned region.

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