DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prosap and Shank3

DIOPT Version :9

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:NP_067398.3 Gene:Shank3 / 58234 MGIID:1930016 Length:1805 Species:Mus musculus


Alignment Length:2071 Identity:528/2071 - (25%)
Similarity:785/2071 - (37%) Gaps:693/2071 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGSGAFDDEPPPEPRDGWLLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYG 65
            |.|.||           ..::||:.:|:|...|||:......||..||:||.:|...|:::.|||
Mouse    76 MDGPGA-----------SAVVVRVGIPDLQQTKCLRLDPTAPVWAAKQRVLCALNHSLQDALNYG 129

  Fly    66 LFAPPANGKAGKFLDEERRLGDYPFN--GPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRF 128
            ||.||:.|:|||||||||.|.|||.|  .|:.|||.:||||||....:|::|...|||:|||::|
Mouse   130 LFQPPSRGRAGKFLDEERLLQDYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKF 194

  Fly   129 LECINGGHVEKIAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGS 193
            ::.:.....:|:|::..||||||||..:||:.||::|........||..|.||||.||:||:||.
Mouse   195 MDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLRNGGAHLDFRTRDGL 259

  Fly   194 TALHRAVEHDSLEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQ 258
            ||:|.|....:..|::|||:|||||:|:|.||:||||.|.....:|...|.||||||.||..|..
Mouse   260 TAVHCATRQRNAGALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDEN 324

  Fly   259 GWNEVHQACRHGLVQHLEHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNF 323
            ||.|:|||||.|.||||||||||||:|..:|||||:.||:||:.|||:|||:||||||.:..:|:
Mouse   325 GWQEIHQACRFGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNY 389

  Fly   324 ANQTPYQVAVIAGNLELAEIIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGG 388
            .:||.:|||:||||.||||:|:.:|..|:||||..|.|..:||                      
Mouse   390 NSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRR---------------------- 432

  Fly   389 GFGGAMVGSNGAAN--------------GNNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQN 439
                 :.|.:|.|:              |:..|...|..|....||.      ..|.:..:..::
Mouse   433 -----LAGPSGLASPRPLQRSASDINLKGDQPAASPGPTLRSLPHQL------LLQRLQEEKDRD 486

  Fly   440 HHQQLQQQQLPHLHTLQLHGPPSPCPSEHMLGAYSSASSSLSEGSSGHRSHEDDISIVTDKSLGD 504
            ...:|:.         .:.||                    |.|..||..       ::....|.
Mouse   487 RDGELEN---------DISGP--------------------SAGRGGHNK-------ISPSGPGG 515

  Fly   505 TSDIISDSSGVGTNSD---------------SAACSIGHPSTTVVCMEPYAGNTVGHIRLQPGDV 554
            :    ..:.|.|..|.               ||.     |....:.::.::....|.|.|..|:.
Mouse   516 S----GPAPGPGPASPAPPAPPPRGPKRKLYSAV-----PGRKFIAVKAHSPQGEGEIPLHRGEA 571

  Fly   555 IEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQ---KHITNVMTASTGMAPQQQQQQHLQQ 616
            ::|:...:.|..||.|:|  ::|:||||||:||.:||   :|.|           ::.:.:.|.:
Mouse   572 VKVLSIGEGGFWEGTVKG--RTGWFPADCVEEVQMRQYDTRHET-----------REDRTKRLFR 623

  Fly   617 APAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQPLESNEGGASGNGINNR 681
                                                                             
Mouse   624 ----------------------------------------------------------------- 623

  Fly   682 NNNHSVGQYSSATAPRIKKSAYNAPRSVVL--HRAKRGFGFILRGAKASSQLMQLRPSERFPALQ 744
              :::||.|.|.|:    .|.|.....|.:  .|...||||:||||||.:.:.:..|:..|||||
Mouse   624 --HYTVGSYDSLTS----HSDYVIDDKVAILQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQ 682

  Fly   745 YLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQAS 809
            ||:.||..|||..||||.||||:.:||.:|....|:|||.:||..|..:.:.|||          
Mouse   683 YLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVS---------- 737

  Fly   810 AQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDPKT 874
                                           :.||          ....|:.|.||.||:|.|.|
Mouse   738 -------------------------------VTRK----------PEEDGARRRAPPPPKRAPST 761

  Fly   875 TLSVGRARAKSMVAGLE-------NGGEKEDDLPHTKSNSVESIATPTPTGIQTGPG-TPVQLRT 931
            ||::   |:|||.|.||       ..|||.|::       :...|.||     ..|. .....|.
Mouse   762 TLTL---RSKSMTAELEELASIRRRKGEKLDEI-------LAVAAEPT-----LRPDIADADSRA 811

  Fly   932 ASIKARPTSSRITAAELEELFQRQQGEG----------------SAANASRYATMMTSSRFQSGT 980
            |::|.||||.|||.||:..||:||...|                |.....:.|::: ..||...|
Mouse   812 ATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLL-EGRFPRST 875

  Fly   981 -------DSGAATPPASNGSPMRSGPLVYGSVAEMKRKTARSKHGSGTLRGKPVATPTVGPGGAG 1038
                   :.....||.....|....|..:.|                   |.|   ||..|    
Mouse   876 SMQDTVREGRGIPPPPQTAPPPPPAPYYFDS-------------------GPP---PTFSP---- 914

  Fly  1039 GGRDLKRFHSTPDLHGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRLNSNQGELKLGGLGAG 1103
                            |...|.|....::|.|.                             |..
Mouse   915 ----------------PPPPGRAYDTVRSSFKP-----------------------------GLE 934

  Fly  1104 SATGAGGAVLPPPNHPPPPPPVGQVVKVETRSSVSEYESTISL------------QQKLKKRTEN 1156
            :..|||.|.|..|:.|..|.|..:..| ..||.:...:|...:            .::.|:|...
Mouse   935 ARLGAGAAGLYDPSTPLGPLPYPERQK-RARSMIILQDSAPEVGDVPRPAPAATPPERPKRRPRP 998

  Fly  1157 DAVTSAAIDGVQSSFNPSAN-----AKIYA--SPQELRNVMAWKLRQAQEKPSQETSA---GSQQ 1211
            ....|           |.||     |.::|  .||..::.:   ::|.|.:.:||.:|   ||..
Mouse   999 SGPDS-----------PYANLGAFSASLFAPSKPQRRKSPL---VKQLQVEDAQERAALAVGSPG 1049

  Fly  1212 PV----SQYAAPTQM--RPAQQQQQAQQPPTALASHYAAPQ---VQVQQVQQVQQS----PQQSA 1263
            ||    ::..:||..  ||......:.:   .|...:..|.   |:.:::::.::|    ...:.
Mouse  1050 PVGGSFAREPSPTHRGPRPGSLDYSSGE---GLGLTFGGPSPGPVKERRLEERRRSTVFLSVGAI 1111

  Fly  1264 PQSPPAPPLPQAAPVPAQNGN--GNGSTSGAGSAPPIP---------EPDYSCSESDGEDENSIL 1317
            ..|||:..||...|..:.:..  |.|:|:|.....|.|         .|....|   |......|
Mouse  1112 EGSPPSADLPSLQPSRSIDERLLGTGATTGRDLLLPSPVSALKPLVGGPSLGPS---GSTFIHPL 1173

  Fly  1318 VARNTKLNEKIALFDVPETSGNSQASGSSSNSGSASISHS----------LSVEEIQRIRSNLKT 1372
            ..:....:..:||    ..:...:|..|.:.|.|.:..||          :.|:.....|..|.:
Mouse  1174 TGKPLDPSSPLAL----ALAARERALASQTPSRSPTPVHSPDADRPGPLFVDVQTRDSERGPLAS 1234

  Fly  1373 SKSSPNGFAKKP-----EEEKPQQEQQQSHQQPQQLLQPGEDECDNSSSGV------SSEQEQLA 1426
            ...||...|..|     |.|||.:|:::|.:..:.::....|......:|:      |:.||...
Mouse  1235 PAFSPRSPAWIPVPARREAEKPPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSR 1299

  Fly  1427 LAAGVTLPGG-------------GKPTDTIKKKPSVTI-----------VEEPKTI------PDQ 1461
            |.|....||.             .:|..:.:.:|..:|           .|||:.:      |.|
Mouse  1300 LGAEEERPGTPELAPAPMQAAAVAEPMPSPRAQPPGSIPADPGPGQGSSEEEPELVFAVNLPPAQ 1364

  Fly  1462 PSSNTSHTTKPMAK----------------TTISIGGGGSAVPTATLTVKQLVQQQHAPVIQQQQ 1510
            .||:...|.:.:|:                ||...|.|  .:||...:..........|...:..
Mouse  1365 LSSSDEETREELARIGLVPPPEEFANGILLTTPPPGPG--PLPTTVPSPASGKPSSELPPAPESA 1427

  Fly  1511 QQLGSKQPVTAASTNKFTQQSNINSNVMSPQVL----GRIPSHH------H----QQQSSNPNQK 1561
            ...|.::..|.:|::...:.::..|.|.|...|    |.:...|      |    ::....|..|
Mouse  1428 ADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPK 1492

  Fly  1562 L--------IATQQQILQQ-QQQQLAHQQHLQQILKAKAAAAGGASNTAVLVAKHQQKLHKGTSS 1617
            |        :..:..:|:| ...:|..|||       .||:.|.||                 ::
Mouse  1493 LKSPLGKGPVTFRDPLLKQSSDSELMAQQH-------HAASTGLAS-----------------AA 1533

  Fly  1618 GHESEMETRSDLEDDDGDLSPSPPAKAFQRHNSLTRKQAAAIAMQRGATRTTAVSLMQLPPPLEA 1682
            |                   |:.|...|||.:.|......:    ||           ||.|   
Mouse  1534 G-------------------PARPRYLFQRRSKLWGDPVES----RG-----------LPGP--- 1561

  Fly  1683 DSDGEPSQLTLQRQQSHHPSQTHPHPHQLQQQLQLQQQQQQQQQQQQPM---------------- 1731
             .|.:|:.::                 :|..:|| |..:..:...::|:                
Mouse  1562 -EDDKPTVIS-----------------ELSSRLQ-QLNKDTRSLGEEPVGGLGSLLDPAKKSPIA 1607

  Fly  1732 AAHIVGMLPSGQLVAVASGAVAGVPGVGATAVQQGNNNLQQLCTDNLVLAPPPQFCDCNDAKHAP 1796
            ||.:...|  |:|..:::....|.||.||                :..:.|..::   ..|:.||
Mouse  1608 AARLFSSL--GELSTISAQRSPGGPGGGA----------------SYSVRPSGRY---PVARRAP 1651

  Fly  1797 QPHLPTSQYHPQQQQQQQHQQQQQQQQQLQQQLQQQQMLQMHQRLSG-GAGAGAVG 1851
            .|..|.|.                                  :|:.| |||.|..|
Mouse  1652 SPVKPASL----------------------------------ERVEGLGAGVGGAG 1673

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_f0 20..103 CDD:293120 42/84 (50%)
Ank_2 128..222 CDD:289560 43/93 (46%)
ANK 131..233 CDD:238125 49/101 (49%)
ANK repeat 157..189 CDD:293786 14/31 (45%)
ANK 186..312 CDD:238125 75/125 (60%)
ANK repeat 191..222 CDD:293786 16/30 (53%)
Ank_2 196..322 CDD:289560 74/125 (59%)
ANK repeat 224..289 CDD:293786 40/64 (63%)
ANK repeat 291..322 CDD:293786 19/30 (63%)
ANK repeat 324..353 CDD:293786 16/28 (57%)
SH3 532..586 CDD:302595 17/53 (32%)
PDZ_signaling 706..798 CDD:238492 43/93 (46%)
Shank3NP_067398.3 Ubiquitin_like_fold 83..169 CDD:391949 42/85 (49%)
ANKYR 200..392 CDD:223738 105/191 (55%)
ANK repeat 222..255 CDD:293786 14/32 (44%)
ANK repeat 257..288 CDD:293786 16/30 (53%)
ANK repeat 290..355 CDD:293786 40/64 (63%)
Ank_2 329..410 CDD:372319 54/80 (68%)
ANK repeat 357..388 CDD:293786 19/30 (63%)
SH3 548..599 CDD:388381 15/52 (29%)
PDZ_signaling 647..736 CDD:238492 42/88 (48%)
PRK12323 <1204..>1428 CDD:237057 43/225 (19%)
SAM_Shank1,2,3 1738..1803 CDD:188905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838528
Domainoid 1 1.000 54 1.000 Domainoid score I11171
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 406 1.000 Inparanoid score I1870
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001441
OrthoInspector 1 1.000 - - otm44187
orthoMCL 1 0.900 - - OOG6_103134
Panther 1 1.100 - - O PTHR24135
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X750
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.890

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