DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prosap and CASKIN1

DIOPT Version :9

Sequence 1:	NP_610925.3	Gene:	Prosap / 50225	FlyBaseID:	FBgn0040752	Length:	1871	Species:	Drosophila melanogaster
Sequence 2:	NP_065815.1	Gene:	CASKIN1 / 57524	HGNCID:	20879	Length:	1431	Species:	Homo sapiens

Alignment Length:	1601	Identity:	321/1601 - (20%)
Similarity:	509/1601 - (31%)	Gaps:	495/1601 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KQQVLASLPKELKESFNYGLFAPPANGKAGKFLDEERRLGDYPFNGPVGYLELKYKRRVYKMLTL 111
            |:|.|....|.........|...|..||| |.|...::: :..|..|.|:
Human     3 KEQELVQAVKAEDVGTAQRLLQRPRPGKA-KLLGSTKKI-NVNFQDPDGF--------------- 50

  Fly   112 DERQLKALHTRANLRRFLECINGGHVEKIAKM----CAKGLDPNFHCSESGDTPLTVAT--GAKK 170
                 .|||..|        :| |:.|.|:.:    .|..:..|     .|..||..|.  |.|:
Human    51 -----SALHHAA--------LN-GNTELISLLLEAQAAVDIKDN-----KGMRPLHYAAWQGRKE 96

  Fly   171 PNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVSTLLELGASPNYRDGRGITPLYISITR 235
            |.||::   ..|:.::..:.:|...||.|.:|...:....||:..::|...|..|.|||.::
Human    97 PMKLVL---KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA--- 155

  Fly   236 KCE---AKITESLLHDHATLGI--------QDSQGWNEVHQACRHGLVQHLEHLLFYGADMDGRN 289
             ||   ..:.:.||..:....:        .|..|.:.:|.|.::|.:..:..||..|.|::.:.
Human   156 -CEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQT 219

  Fly   290 ASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTP----YQVAVIAGNLELAEIIE----- 345
            .||.: ||..|:..:....|:||..|.....:|..:||.    :|......:.|:.:::.
Human   220 KSGTA-LHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAA 283

  Fly   346 ------------------NYKSEDIVP---------FRGPPRYNPKRRSGIGWLSANGAAGAALL 383
                              |.|:.||:.         ::|....|......:|:..:  :.|.|::
Human   284 LQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPS--SLGEAIV 346

  Fly   384 AAAGGG------------------------------FGGAMVGSNGAANGNNGAGGVGLMLSHQN 418
            ..||..                              .||...||.....|..|:||..|
Human   347 KRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHAL------ 405

  Fly   419 HQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPCPSEHMLGAYSSASSSLSEG 483
                |||....:.:        ...|.|:.:.       ...|...|::...|:...|.|.....
Human   406 ----HAGSEGVKLL--------ATVLSQKSVS-------ESGPGDSPAKPPEGSAGVARSQPPVA 451

  Fly   484 SSGHRSHEDDISIVTDKSLGDTSDIISD---------------SSGVG-------TNSDSAACSI 526
            .:|....|.....:...|.|.:|:.:|.               |:|..       |..|..|..:
Human   452 HAGQVYGEQPPKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGV 516

  Fly   527 GHPSTTVVCMEPYAGNTV-----GHIRLQPGDV---IEVVGSTDCGLLEGYVRGTNQSGFFPADC 583
            ..|..........:|.::     .|   :|.::   :.::|      |..|.:....:|:...|.
Human   517 TKPGHRKKIAAEISGLSIPDWLPEH---KPANLAVWLSMIG------LAQYYKVLVDNGYENIDF 572

  Fly   584 V--------QEVSL-RQKHITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSG 639
            :        ||:.: :..|...:|.|...:|..|:.:.           |.|:|.|.......|.
Human   573 ITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEY-----------AKYEGGPLRRKAPQSL 626

  Fly   640 SSSTLLQQPH--------QSPSLSVASNGSCQQPLESNEGGASGNGINNRNNNHSVGQYSSATAP 696
            ....:...|.        |||.::...:......|::...|.:           .||..:.
Human   627 EVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPA-----------EVGPTTE---- 676

  Fly   697 RIKKSAYNAPRSVVLHRAKRGFGFILRGAKASSQLMQLRP----SERFPALQYLDDVDPGGVADM 757
              |.|::..|......|.....|...|...:|.:|:...|    |....:.:||.|..|......
Human   677 --KPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPP 739

  Fly   758 AGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQASAQYLPSGARAGSH 822
            ...|||.     :|..:..||...|....|.        |:.|...|   .:....|:..|.||.
Human   740 REARPGR-----HGHSIKRASVPPVPGKPRQ--------VLPPGTSH---FTPPQTPTKTRPGSP 788

  Fly   823 HLNSGP---------------------------STPQS-SHRQCA-TLPRKMTGP-GGSGPGSSS 857
            ....||                           |.||| :||..| .||:.:.|. |.:.||.:.
Human   789 QALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAP 853

  Fly   858 GGSVRMAP---MPPRRDPKTTLSVGRARAKSMVAGLENGGEKEDDL------PHT-------KSN 906
            .......|   :||..|.:......||.:.:..|..::..|:::.|      |:.       :|:
Human   854 PPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSH 918

  Fly   907 SVESIATPTPTGI---------------QTGPGTPVQLRTAS--IKARPTSSRITAAELEE--LF 952
            ||.:     |.|.               :.||..|...|::|  ..|......:..||.|:  |.
Human   919 SVRA-----PAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLG 978

  Fly   953 QRQQ-----------GEGSAANASRYATMMTSSRFQSGTDSGAATPPASNGSPMRSGP---LVYG 1003
            .|.|           ..|||.:....|.|:..|.. .|....|..||..:.:|..:.|   .|..
Human   979 VRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSI-GGGGRAARRPPEGHPTPRPASPEPGRVAT 1042

  Fly  1004 SVAEMKRKTA---------RSKHGSGTLRGKPVATPTVGPGGA---------GGGRDLKRFHSTP 1050
            .:|.:|.|.|         |.:..||.:.|. :||...|||.:         |.||...|..|..
Human  1043 VLASVKHKEAIGPGGEVVNRRRTLSGPVTGL-LATARRGPGESADPGPFVEDGTGRQRPRGPSKG 1106

  Fly  1051 D--LHGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRLNSNQGELKL---------------- 1097
            :  :.||.|....:|               |||...::...:.|..:|.
Human  1107 EAGVEGPPLAKVEAS---------------ATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKE 1156

  Fly  1098 ---------------GGLGA----GSATGAGGAVL---PPPNHPPP---------PPPVGQVVKV 1131
                           .|.|.    .::..||...|   |||..|||         |||.|:.
Human  1157 REAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEA--- 1218

  Fly  1132 ETRSSVSEYESTISLQQKLKKRTENDAVTSAAIDGVQSSFNPSANAKIYASPQELRNVMAWKLRQ 1196
                           ::..|.......|.:..:..:|.|..|::.......|
Human  1219 ---------------RKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGP------------- 1255

  Fly  1197 AQEKPSQETSAGSQQPVSQY-----AAPTQMR-----------PAQQQQQAQQPPTALASHYAAP 1245
              ..|..:.:.|:..|||..     .||..::           |:.....|:|||.|||.....|
Human  1256 --GSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTP 1318

  Fly  1246 QVQVQQVQQVQQSPQQSA-PQSPPAPPLPQAAPVPAQNGNGNGSTSGAGSAPPIPEPDYSCSESD 1309
                         |...| |..||:|..| |..|||:......:.:.|.:|||.|....|..:|.
Human  1319 -------------PSLGASPAKPPSPGAP-ALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSA 1369

  Fly  1310 G---EDENSILVARNTKLNEKIALFDV--PETSGNSQASGS 1345
            .   |:.::.|.|....:.|||...|.  |..|...:::||
Human  1370 RQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGS 1410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_f0	20..103	CDD:293120	14/55 (25%)
		Ank_2	128..222	CDD:289560	24/99 (24%)
		ANK	131..233	CDD:238125	29/107 (27%)
		ANK repeat	157..189	CDD:293786	10/33 (30%)
		ANK	186..312	CDD:238125	32/136 (24%)
		ANK repeat	191..222	CDD:293786	8/30 (27%)
		Ank_2	196..322	CDD:289560	34/136 (25%)
		ANK repeat	224..289	CDD:293786	17/75 (23%)
		ANK repeat	291..322	CDD:293786	9/30 (30%)
		ANK repeat	324..353	CDD:293786	7/55 (13%)
		SH3	532..586	CDD:302595	8/69 (12%)
		PDZ_signaling	706..798	CDD:238492	20/95 (21%)
CASKIN1	NP_065815.1	Ank_4	7..69	CDD:290365	20/92 (22%)
		ANK repeat	7..46	CDD:293786	10/40 (25%)
		ANK	43..168	CDD:238125	38/165 (23%)
		ANK repeat	48..79	CDD:293786	10/59 (17%)
		ANK 1	48..77		10/57 (18%)
		Ank_2	53..145	CDD:289560	27/108 (25%)
		ANK repeat	81..112	CDD:293786	10/33 (30%)
		ANK 2	81..110		10/31 (32%)
		ANK	109..241	CDD:238125	32/136 (24%)
		ANK repeat	114..145	CDD:293786	8/30 (27%)
		ANK 3	114..143		8/28 (29%)
		Ank_2	119..218	CDD:289560	25/102 (25%)
		ANK repeat	147..186	CDD:293786	8/42 (19%)
		ANK 4	147..176		8/32 (25%)
		ANK repeat	188..218	CDD:293786	8/29 (28%)
		ANK 5	188..217		8/28 (29%)
		Ank_5	208..261	CDD:290568	16/53 (30%)
		ANK 6	220..249		9/29 (31%)
		ANK repeat	221..251	CDD:293786	9/30 (30%)
		ANK repeat	253..287	CDD:293786	4/33 (12%)
		SH3_Caskin1	284..345	CDD:212995	8/62 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..373		2/24 (8%)
		Caskin1-CID	373..421	CDD:293208	13/65 (20%)
		CASK-binding. /evidence=ECO:0000250	375..469		21/118 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..447		5/32 (16%)
		SAM	470..532	CDD:197735	9/61 (15%)
		SAM_caskin1,2_repeat1	471..536	CDD:188896	10/64 (16%)
		SAM_caskin1,2_repeat2	537..607	CDD:188897	13/78 (17%)
		SAM	549..604	CDD:197735	10/60 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..977		76/384 (20%)
		Ten_N	<651..>809	CDD:284015	35/190 (18%)
		Caskin-Pro-rich	876..947	CDD:293512	13/75 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1014..1039		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1377		76/367 (21%)
		Caskin-tail	1370..1431	CDD:293238	11/41 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1390..1416		7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000