DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prosap and shank2a

DIOPT Version :9

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:XP_021323618.1 Gene:shank2a / 572407 ZFINID:ZDB-GENE-120215-55 Length:1707 Species:Danio rerio


Alignment Length:1801 Identity:457/1801 - (25%)
Similarity:672/1801 - (37%) Gaps:584/1801 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKFLDEERR 84
            |:|::.:|:|...|||:|.....||..||::|.:|.:.||:..|:|||.|.::|..| ||:||..
Zfish    54 LMVQVFIPDLQQTKCLRFDPCASVWAAKQRILCTLSQNLKDVLNFGLFQPSSSGDGG-FLEEESL 117

  Fly    85 LGDYPFNGPVG----YLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEKIAKMCA 145
            :||.|.  |.|    .||.:||.|:|...::||:|:..|||:||||||::||....:||:::|..
Zfish   118 MGDLPV--PAGESLPMLEFRYKTRLYSQSSVDEKQIARLHTKANLRRFMDCILHRQLEKVSRMLD 180

  Fly   146 KGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVST 210
            ||||||:..||||:.|||:|...:...:.:.||.||||.||:|.|||.||||:|....:.:|:.|
Zfish   181 KGLDPNYQDSESGEAPLTLAVQMESMVEFIKALRNGGAHLDFRAKDGMTALHKAACAKNQDALKT 245

  Fly   211 LLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRHGLVQHL 275
            ||:||||||.:|.||:|.||.::|...|....|.||..:..|..||..||.|.|||||||.|:||
Zfish   246 LLDLGASPNSKDSRGLTALYHTVTAGGETHCCELLLDANTALCCQDENGWQETHQACRHGYVEHL 310

  Fly   276 EHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVIAGNLEL 340
            ||||.|||||..:|||||:|||:||:.|||.||.:||.|||.:..:|:::|:|:|||:|:||.||
Zfish   311 EHLLCYGADMSAQNASGNTPLHICALYNQEKCAHVLLLRGADKDMKNYSSQSPFQVALISGNFEL 375

  Fly   341 AEIIENYKSEDIVPFRGPP---RYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNGAAN 402
            ||:|:|::..:.|...||.   |.|.|:                                     
Zfish   376 AELIKNHRDPEPVSRSGPQLSCRLNEKK------------------------------------- 403

  Fly   403 GNNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPCPSE 467
                                                                     |......:
Zfish   404 ---------------------------------------------------------PQVATAVD 411

  Fly   468 HMLGAYSSASSS--LSEGSSGHRSHEDDISIVTDKSLGDTSDIISDSSGVGTNSDSAACSIGHPS 530
            :.|..:|:||.:  ...|::.|....|    |.:.::|                 ||.|:     
Zfish   412 YELIIFSAASDAPQTLAGAAAHARGWD----VAETAMG-----------------SACCT----- 450

  Fly   531 TTVVCMEPYAGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKHIT 595
                                    .|.||.:|........|...:||.    |:....||.....
Zfish   451 ------------------------AERVGLSDTPSASRGRRPLPRSGV----CMSRSLLRSSSDI 487

  Fly   596 NVMTASTGMAPQQQQQQ-------HLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPS 653
            ||...:  ::|:.||.|       .:....:|.|......|..||:.         |:..|.|.:
Zfish   488 NVPERT--VSPELQQMQRDAGARMRMMMMTSGRSGRMKSNSRSLSVS---------LEDEHSSST 541

  Fly   654 LSVASNG-----SCQQPLESNEGGA-----------SGNGIN---NRN----------------- 682
            .....||     |.::.|.|...|.           :|.|.|   :||                 
Zfish   542 TLKCPNGRVCVPSSRRKLYSATSGRHVLLVRSCLPHAGGGENSSLHRNGRVRDSRAERSDRKKLF 606

  Fly   683 NNHSVGQYSSATAPRIKKSAYNAPRSVVLHRA-KRGFGFILRGAKASSQLMQLRPSERFPALQYL 746
            .:.:||.|.|...   ........::|||.:. ..||||:||||||.:.:.:..|:..|||||||
Zfish   607 RHFTVGSYDSMDN---SSDCTTEQKTVVLQKQDSEGFGFVLRGAKADTPIEEFIPTAAFPALQYL 668

  Fly   747 DDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQASAQ 811
            :.||.||||.:.|||.||||..:|.:.|....|.|||.||:..|..:.:.||             
Zfish   669 ESVDEGGVAWLMGLRTGDFLTEVNHQSVVKMGHRQVVSMIKHGGNRLVIKVV------------- 720

  Fly   812 YLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDPKTTL 876
                       .::..|.......|                         :.||.||:|.|.|.|
Zfish   721 -----------RVSRNPDDKDDKTR-------------------------KKAPPPPKRAPTTAL 749

  Fly   877 SVGRARAKSMVAGLENGGEKEDDLPHTKSNSVESIATPTPTGIQTGPGTPVQLRTASIKARPTSS 941
            ::   |:|||...||:..:.|:.:|..|....:|.|.                :|.||::||   
Zfish   750 TM---RSKSMTCELEDPDKVEEAVPPQKIMHEKSSAD----------------KTVSIRSRP--- 792

  Fly   942 RITAAELEELFQRQQGEGSAANASRYATMMTSSRFQSGTDSGAATPPASNGSPMRSGPLVYGSVA 1006
                                  :||:...|..::..|.....|..||   ..|.||    :|...
Zfish   793 ----------------------SSRFLASMDFNQSASERPGVAVVPP---NVPGRS----HGGYI 828

  Fly  1007 EMKRKTARSKHGSGTLRGKPVATPTVGPGGAGGGRDLKRFHSTPDLHGPQLHGSASSIWQASGKG 1071
            .:.:.:.|        |.|.|       |.||   :.|:|     |..|.|..|.|.        
Zfish   829 RLPKSSMR--------RQKSV-------GIAG---EEKKF-----LIPPLLKFSRSL-------- 862

  Fly  1072 HHSQDDVATLHASLQRLNSNQGELKLGGLGAGSATGAGGAVLPPPNHPPPPPPVGQVVKVETRSS 1136
              |..|.:.                              .:.|||...||.||    .|:.| |:
Zfish   863 --SMPDTSE------------------------------DIPPPPGISPPSPP----YKLST-ST 890

  Fly  1137 VSEYESTISLQQKLKKRTENDAVTSAAIDGVQSSFNPSANAKIYASPQELRNVMAWKLRQAQEKP 1201
            ...||...|:.      |:|.|.....|:..|..:: ..|.:.|               ..|..|
Zfish   891 AQGYEPNQSIY------TQNSAARCHTIERDQVGYH-RQNFEPY---------------DCQTHP 933

  Fly  1202 SQETSAGSQQPVSQ---YAAPTQMRPAQQQQQAQQPPTALASHYAAPQVQVQQVQQVQQSPQQSA 1263
            ....:...:.|.|.   |..|   :||:::....:.|                  .|:.||:::.
Zfish   934 GLNRAHVPENPYSDKPLYVPP---KPARRKGILVKQP------------------NVEDSPEKTC 977

  Fly  1264 PQSPPAPPLPQAAPVPAQNGNGNGSTSGAGSAPPIPEPDYSCSESDGEDENSILVARNTKLNEKI 1328
            ..|.|...:.:    |:.:.:|.   |..||:..|        |:.|                  
Zfish   978 SISIPTIIVKE----PSTSSSGK---SSRGSSMEI--------ETTG------------------ 1009

  Fly  1329 ALFDVPETSGNSQASGSSSNSGSASISHSLSVEEIQRIRSNLKTSKSSPNGFA-----KKPEEEK 1388
                 ||..|..:..||.||..:|:|:.::...|     ..|:..|:||...:     :.|....
Zfish  1010 -----PEPPGQLRPDGSVSNPFAAAIAGAVRDRE-----KRLEARKNSPAFLSMDLGDEDPFIPT 1064

  Fly  1389 PQQEQQQSHQQPQQLLQPGEDECDNSSSGVSSEQEQLALAAGVTLPGGGKPTDTIKKKPSVTIVE 1453
            |:..|..|       :..|....|.|...:.:  ...:|.....|...|..||.           
Zfish  1065 PRLRQSMS-------IDEGMFANDKSLENIMA--PPASLIGSSQLRNEGNLTDF----------- 1109

  Fly  1454 EPKTIPDQPSSNTSHTTKPMAKTTISIGGGGSAVPTATLTVKQLVQQQH----APVIQQQQQQLG 1514
               |||:.       .|||:...:......||.:.......:|:.::.|    .|...|......
Zfish  1110 ---TIPEP-------MTKPLTTRSRKCPDIGSPIGIDDDFQQQVSRKTHDICSPPAPGQSSGNKA 1164

  Fly  1515 SKQPVT-----------AASTNK--FTQ---QSNINSNVMSPQVLGRIPS-----HHHQQQSSNP 1558
            .|:||.           .|:.|:  |..   :|||.:|..:...:|: |.     ..|.::||..
Zfish  1165 LKEPVLPPLPPPKGEPHKANLNQPLFIDTKLRSNIETNFAATTAVGQ-PKDSGGLFRHSRESSRQ 1228

  Fly  1559 NQKLIATQQQIL---QQQQQQLAHQQHLQQILKAKAAAAGGASNTAVLVAK--------HQQKLH 1612
            ..|:....:|:.   ...||:.|....:|.:.|||  ..|.:.:...|:.:        ...||.
Zfish  1229 TVKVSNPSEQLKNAHNTSQQKSAGLLMVQSLNKAK--PQGNSLSDGFLLEESPVMDGEPSDSKLP 1291

  Fly  1613 KGT----------SSGHESEMETRSDLEDDDGDLSPSPPAKAFQRHNSLTRKQAAAIAMQRGATR 1667
            ...          |||....:.|..|::::.....|.||...|.....:...|.|.|..|:....
Zfish  1292 NSQTTPMEEPGKFSSGIPLPLLTSVDIDEEFDVAEPLPPPLEFANSLDIPEDQVAVILKQKKNNE 1356

  Fly  1668 TTAV----------SLMQLPPP------------LEAD---SDGEP 1688
            |.||          |....|||            .|||   |.|:|
Zfish  1357 TRAVHHSRASNCMTSHAYPPPPPEMFEPVTDSGIEEADSRNSAGDP 1402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_f0 20..103 CDD:293120 35/86 (41%)
Ank_2 128..222 CDD:289560 47/93 (51%)
ANK 131..233 CDD:238125 52/101 (51%)
ANK repeat 157..189 CDD:293786 14/31 (45%)
ANK 186..312 CDD:238125 71/125 (57%)
ANK repeat 191..222 CDD:293786 17/30 (57%)
Ank_2 196..322 CDD:289560 69/125 (55%)
ANK repeat 224..289 CDD:293786 35/64 (55%)
ANK repeat 291..322 CDD:293786 18/30 (60%)
ANK repeat 324..353 CDD:293786 14/28 (50%)
SH3 532..586 CDD:302595 8/53 (15%)
PDZ_signaling 706..798 CDD:238492 43/92 (47%)
shank2aXP_021323618.1 FERM_f0 54..136 CDD:318667 34/84 (40%)
Ank_2 163..257 CDD:315466 47/93 (51%)
ANK repeat 163..189 CDD:293786 12/25 (48%)
ANK repeat 192..224 CDD:293786 14/31 (45%)
ANK 221..347 CDD:238125 71/125 (57%)
ANK repeat 226..257 CDD:293786 17/30 (57%)
ANK repeat 259..324 CDD:293786 35/64 (55%)
ANK 322..>392 CDD:238125 36/69 (52%)
ANK repeat 326..357 CDD:293786 18/30 (60%)
ANK repeat 359..388 CDD:293786 14/28 (50%)
PDZ_signaling 628..720 CDD:238492 43/91 (47%)
SAM_Shank1,2,3 1640..1705 CDD:188905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001441
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103134
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.900

Return to query results.
Submit another query.