DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prosap and shank2b

DIOPT Version :9

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:XP_017209578.1 Gene:shank2b / 567595 ZFINID:ZDB-GENE-061207-58 Length:1810 Species:Danio rerio


Alignment Length:1993 Identity:507/1993 - (25%)
Similarity:749/1993 - (37%) Gaps:559/1993 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SGSGAFDDEPP--PEPRDG-----WLLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELK 59
            |.|.:..||||  ..|..|     ..|:.:.:|:|...|.::|..:..||..|||:|.:|.:.|:
Zfish    22 SDSDSSRDEPPRLDRPTSGRQDNNTTLICVVIPDLQQSKSMRFSPDATVWVAKQQILCTLTQSLR 86

  Fly    60 ESFNYGLFAPPANGKAGKFLDEERRLGDYPFNGPVGY--LELKYKRRVYKMLTLDERQLKALHTR 122
            :..|||||.|..:|:...||:|||.|.|||.:...|.  ||.:||.|||:...::|:|::.|||:
Zfish    87 DVLNYGLFQPAVDGRESGFLEEERLLRDYPLSSTKGIPTLEFRYKSRVYQQPNVNEKQIEKLHTQ 151

  Fly   123 ANLRRFLECINGGHVEKIAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDY 187
            .|||:|:|.|....|||:|||..:|||||:|..::|:||||:|.......::::.|.||||.||:
Zfish   152 VNLRKFMEYIQHHQVEKVAKMLERGLDPNYHDPDTGETPLTLAAHLDNMLEIIVTLKNGGAHLDF 216

  Fly   188 RTKDGSTALHRAVEHDSLEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATL 252
            |::||.||||:|....:..|:.|:|:|||||:|:|.:|:||||.::|...:....|.||..||::
Zfish   217 RSRDGMTALHKAARAKNQIALKTMLDLGASPDYKDRQGLTPLYHTVTVGGDPSCCEVLLRAHASV 281

  Fly   253 GIQDSQGWNEVHQACRHGLVQHLEHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQ 317
            |..|..||:|:|||||:|.||||||||||||||...|||||:.||:||:..||.|||:||.|||.
Zfish   282 GCHDENGWHEIHQACRYGHVQHLEHLLFYGADMHVENASGNTALHICALYKQEKCARVLLVRGAS 346

  Fly   318 RGAQNFANQTPYQVAVIAGNLELAEIIENYKSEDIVPFRGPP----RYNPKRRSGIGWLSANGAA 378
            :..:|:..|||:|||:||||.||||.|:|:|..||||||..|    |..|.::|.:      ...
Zfish   347 KDVKNYRGQTPFQVAIIAGNFELAEFIKNHKEADIVPFREAPAGTGRSRPSQQSPL------QHQ 405

  Fly   379 GAALLAAAGGGFGGAMVGSNGAANGNNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQ 443
            |.:.|||.     ..::.||...|.|..      .||.:..:.........:.:..:|.|     
Zfish   406 GRSTLAAP-----RVLLRSNSDNNLNVN------KLSLERSRSPSPAASPLRSLSPRHPQ----- 454

  Fly   444 LQQQQLPHLHTLQLHGPPSPCPSEHMLGAYSSASSSLSEGSSGHRSHEDDISIVTDKSLGDT--- 505
                        |:...|:.......||..|:.|.|.|.|..|.               |||   
Zfish   455 ------------QMQNSPNGTVKTMALGGRSARSRSPSLGRLGE---------------GDTRRQ 492

  Fly   506 SDIISDS--------SGVGTNSDSAACSIGHPSTTVVCMEPYAGNTVGHIRLQPGDVIEVVGSTD 562
            :.:...|        ||:.|...........|....|.::.|.....|.|.|...|.::|:...:
Zfish   493 TPLRHSSPRANRDAFSGIETPGSKRKLYSAVPGRHYVVVKSYQPQAEGEIVLYKNDRVKVLSIGE 557

  Fly   563 CGLLEGYVRGTNQSGFFPADCVQEVSLRQKHITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQ 627
            .|..||..||  ..|:|||:||:|:                                        
Zfish   558 GGFWEGSARG--NVGWFPAECVEEI---------------------------------------- 580

  Fly   628 GSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQPLESNEGG--ASGNGINNRN--NNHSVG 688
                                                 |.:.||..  |..:....|.  .:::||
Zfish   581 -------------------------------------PSKPNEDRPYARADRSERRKLFRHYTVG 608

  Fly   689 QYSSATAPRIKKSAYNAPRSVVLHRAKRGFGFILRGAKASSQLMQLRPSERFPALQYLDDVDPGG 753
            .|.|..|.  .....|....|:..:...||||:||||||.:.:.:..|:..|||||||:.||.||
Zfish   609 SYDSFDAS--SDCVINEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGG 671

  Fly   754 VADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQASAQYLPSGAR 818
            ||..||||.||||:.:|.::|....|:|||.|||..|..:.:.||:.                  
Zfish   672 VAWKAGLRTGDFLIEVNQDNVVKVGHKQVVNMIRHGGNHLIIKVVTV------------------ 718

  Fly   819 AGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDPKTTLSVGRARA 883
              |.:|:     |..:.|                         :.||.||||.|.|.||:   |:
Zfish   719 --SRNLD-----PDDTAR-------------------------KKAPPPPRRAPSTALSM---RS 748

  Fly   884 KSMVAGLENGGEKEDDLPHTKSNSVESIATPTPTGIQTGPGTPV------QLRTASIKARPTS-- 940
            |||.:.||:..:|.  ....|.:.|:.:..|.         .|:      ::|.|::|.||||  
Zfish   749 KSMTSELEDLVDKA--TLRKKKDKVDEVVPPQ---------KPIWDNSNAEVRVATVKPRPTSKC 802

  Fly   941 ------------SRITAAELEE---------------LFQRQQGEGSAANASRYAT--MMTSSRF 976
                        |:.||.:...               ..:||...|......::.|  |:..:|.
Zfish   803 FPVSPEMNSLCNSQDTAVDSSPQPGSPRGPFLGLPRGTIRRQTSIGVTEEEKQFLTPPMLKFTRS 867

  Fly   977 QSGTDSG-------AATPPA--SNGSPMRSGPLVYGSVAEMKRKTARSKHGSGTLRG-----KPV 1027
            .|..|:.       |.:||:  .|.:|:.:|                  .|.||:|.     .|.
Zfish   868 LSMPDTSEDIPPPPAISPPSPPHNNAPVPAG------------------RGYGTIRAGFTSQSPN 914

  Fly  1028 ATPTVGPGGAGGG-RDL-KRFHSTPDLHGPQLHGSASSIWQASGKGH-HSQDDVATLHASLQRLN 1089
            |..|....|.|.| ||. |.:...|:              |...:|: ||.....:||....::.
Zfish   915 ANSTAPERGEGAGWRDQGKYYRDNPE--------------QYDSEGYNHSPTAQQSLHMRRAQIP 965

  Fly  1090 SNQ----GELKLGGLGAGSATGAGGAVLPPPNHPPPPP------PVGQVVKVETRSSVS------ 1138
            .|.    |::...||...:.......:|...::....|      |:..::..|..:|.|      
Zfish   966 ENPYSDVGKMGQAGLFVPNKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIIKEPSTSSSGKSSQG 1030

  Fly  1139 ---EYESTI----------------------------SLQQKLKKRTENDAV--TSAAIDGVQSS 1170
               |.|:|.                            ..:::|.....:.:.  |.|..:.|..:
Zfish  1031 SSMEIETTTPDHPGQLRPEDGLNPGSPFAAAIAGAVRDREKRLDSHRNSPSFRSTDAGDEDVVPT 1095

  Fly  1171 FNP------SANAKIYASPQELRNVMAWKLRQAQEKPSQETS---AGSQQPVSQYAAPTQMRPAQ 1226
            ..|      |.:..:::|.:.||.:||        .||...|   .|..........||.:|...
Zfish  1096 PTPRLRHSKSIDEGMFSSDERLRRLMA--------PPSSLLSIPRGGGNVTDFNSPEPTMVRELL 1152

  Fly  1227 QQQQAQQPPTALASHYAAPQVQVQQVQQVQQSPQQSAPQSPPAPPL--------PQAAPVPAQN- 1282
            ..:.... |.:|.:|..........|..|...|..  |.||.|..|        .|:.|:|.:: 
Zfish  1153 NTRTGHS-PISLPAHKTYSSGSGNYVHPVTGKPLD--PNSPLALALAARDRAMRDQSQPLPLKSD 1214

  Fly  1283 ----------------------GNGNGSTSG---AGSAPPIPEPDYSCSESDGEDENSILVARNT 1322
                                  |..:.:|.|   .|....:.|..|     :.|.:..:.:.:..
Zfish  1215 PSKLDLNKPLFIDTKLRPNVEVGFSSTATMGRPRGGLRRQMTESKY-----ETESKYQLDLGKPE 1274

  Fly  1323 KLNE--KIALFDVPETSGNSQA--------SGSSSNSGSAS-------ISHSLSVEEIQRIRSNL 1370
            |..|  |..|.|:.:||....|        .|:.|...|.|       :|...:..|::......
Zfish  1275 KRPEEKKNMLIDIVDTSQQKSAGLLMVHTTDGAKSEDNSLSEGERDEGVSPDNTPGELRDPNQPA 1339

  Fly  1371 KTSKSSPNGFAKKP-------------------------------EEE-------KPQQEQQQSH 1397
            .|:..:|...:..|                               :||       .|..|...|.
Zfish  1340 PTNPPAPKALSAAPHGKTIITVSSVDEPVKLPFGIPPPPLASVDIDEEFVFAEPLPPPLEFANSF 1404

  Fly  1398 QQPQQLLQPGE-----DECDNSSSGVSSEQEQLALAAGVTLPGGGKPTDTIKKKPSVTIVEEPKT 1457
            ..|:.  |.|.     .:..|.:.|.|       ||......|||..  .||:...:|....|..
Zfish  1405 DIPED--QAGSIAELLKQKANGTKGPS-------LAPYYPALGGGHA--EIKRSTVLTNCTPPSF 1458

  Fly  1458 IP---------------------DQPSSNTSHTTKPMAKTTISIGGGGSAVPTATLTVKQLVQQQ 1501
            .|                     ..|...|:.|...::..:.....||..:.|.|      |...
Zfish  1459 PPGPLEPYEQITDSGIEVDSRSSGDPQLETTSTISTVSSISTLSSEGGETLDTCT------VYAD 1517

  Fly  1502 HAPVIQQQQQQLGSKQPVTAASTNKFTQQSNINSNVMS--------PQVLGRIPSHHHQQQSSNP 1558
            ....:..:.|.|...:|..|..:|...:.|....||.|        |...|.||    .:....|
Zfish  1518 GQAFLVDRSQILSKPKPKPAIKSNALYKDSLPEENVGSFRMPSSVPPPPPGSIP----PEPLKTP 1578

  Fly  1559 NQKLIATQQQILQQQQQQLAH----QQHLQQILKAKAAAAGGASNTAVLVAKHQQKLHKGTS--- 1616
            .|:   |.:......:.:..|    ...||.:.|.||...|.|     |.:....:.|.||.   
Zfish  1579 TQR---TSKLWGDPPEMKGPHGPETNSVLQHVNKDKAPKPGEA-----LDSPTGSRTHFGTRNQD 1635

  Fly  1617 -----SGHESEMETRSDLEDDDGDLSPSP--PAKAFQRHNSLTRK--------QAAAIAMQRGAT 1666
                 ||.:.........:......:|||  .|::...|:.....        .:.|.::...||
Zfish  1636 GVSLISGTQQNTTVTFTAQPGPNVPAPSPCRQAESLPPHHHTPSPIMSPPDSGLSCASSLPTSAT 1700

  Fly  1667 RTTAVSLMQLP-PPLEADS--DGEPSQLTLQRQQSHHPSQTHP 1706
            ..|...:..|| |||...:  ...||.|||.:..|:.|..|.|
Zfish  1701 SPTMTDVFGLPTPPLSLGTGRSRSPSPLTLIQAASNKPFATKP 1743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_f0 20..103 CDD:293120 33/84 (39%)
Ank_2 128..222 CDD:289560 45/93 (48%)
ANK 131..233 CDD:238125 49/101 (49%)
ANK repeat 157..189 CDD:293786 13/31 (42%)
ANK 186..312 CDD:238125 69/125 (55%)
ANK repeat 191..222 CDD:293786 16/30 (53%)
Ank_2 196..322 CDD:289560 68/125 (54%)
ANK repeat 224..289 CDD:293786 36/64 (56%)
ANK repeat 291..322 CDD:293786 17/30 (57%)
ANK repeat 324..353 CDD:293786 18/28 (64%)
SH3 532..586 CDD:302595 18/53 (34%)
PDZ_signaling 706..798 CDD:238492 43/91 (47%)
shank2bXP_017209578.1 FERM_f0 51..130 CDD:318667 31/78 (40%)
Ank_2 157..251 CDD:315466 45/93 (48%)
ANK repeat 187..218 CDD:293786 13/30 (43%)
ANK 215..373 CDD:238125 89/157 (57%)
ANK repeat 220..251 CDD:293786 16/30 (53%)
ANK repeat 254..285 CDD:293786 12/30 (40%)
ANK repeat 287..318 CDD:293786 23/30 (77%)
ANK repeat 320..351 CDD:293786 17/30 (57%)
ANK repeat 353..379 CDD:293786 17/25 (68%)
SH3 526..577 CDD:327375 16/52 (31%)
PDZ_signaling 623..716 CDD:238492 43/92 (47%)
SAM_Shank1,2,3 1743..1808 CDD:188905 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170582292
Domainoid 1 1.000 72 1.000 Domainoid score I9300
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 573 1.000 Inparanoid score I1015
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001441
OrthoInspector 1 1.000 - - otm25950
orthoMCL 1 0.900 - - OOG6_103134
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3037
SonicParanoid 1 1.000 - - X750
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.820

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