DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prosap and Tamalin

DIOPT Version :9

Sequence 1:	NP_610925.3	Gene:	Prosap / 50225	FlyBaseID:	FBgn0040752	Length:	1871	Species:	Drosophila melanogaster
Sequence 2:	NP_062391.3	Gene:	Tamalin / 56149	MGIID:	1860303	Length:	392	Species:	Mus musculus

Alignment Length:	337	Identity:	79/337 - (23%)
Similarity:	125/337 - (37%)	Gaps:	92/337 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   691 SSATAPRIKKSAY---NAPRSVVLHR----AKRG----FGFILRGAKASSQLMQLRPSERFPALQ 744
            |..|.||.|.|.:   |..:|....|    .::|    |||     :..:..:..|..:|...:.
Mouse    73 SGGTLPRRKGSGFRWKNFTQSPEQQRKVLTLEKGDNQTFGF-----EIQTYGLHHREEQRVEMVT 132

  Fly   745 YLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNL-TVVSPQF-PHQMQ 807
            ::..|.....|.:|||.|||.:.::||.:|....|.::|::|:::|.::.| |:..... ..:::
Mouse   133 FVCRVHESSPAQLAGLTPGDTIASVNGLNVEGIRHREIVDIIKASGNVLRLETLYGTSIRKAELE 197

  Fly   808 ASAQYLPS----------GARAGSHHLNSG-----PSTPQS--SHRQC----ATLPRKMT-GPGG 850
            |..|||..          ........|..|     ||...:  |.|.|    ..||..:. ||..
Mouse   198 ARLQYLKQTLYEKWGEYRSLMVQEQRLVHGLVVKDPSIYDTLESVRSCLYGAGLLPGSLPFGPLL 262

  Fly   851 SGPGSSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGLENGGEKEDDLPHT---KSNSVESIA 912
            :.|||:.||:                    .|||         |:.:|.:.||   .....:::.
Mouse   263 AAPGSARGGA--------------------RRAK---------GDTDDAVYHTCFFGGAEPQALP 298

  Fly   913 TPTPTGIQTGPG---TPVQLRTASI---KARPTSSRITAAELEELFQRQQGEGSAANASRYATMM 971
            .|.|.....||.   ||     ||:   ..|.|.||..:.       |..|.|....|.  ..:.
Mouse   299 PPPPPARALGPSSAETP-----ASVLFPAPRSTLSRSASV-------RCAGPGGGGGAP--GALW 349

  Fly   972 TSSRFQSGTDSG 983
            |.:|.|:...:|
Mouse   350 TEAREQALCGAG 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_f0	20..103	CDD:293120
		Ank_2	128..222	CDD:289560
		ANK	131..233	CDD:238125
		ANK repeat	157..189	CDD:293786
		ANK	186..312	CDD:238125
		ANK repeat	191..222	CDD:293786
		Ank_2	196..322	CDD:289560
		ANK repeat	224..289	CDD:293786
		ANK repeat	291..322	CDD:293786
		ANK repeat	324..353	CDD:293786
		SH3	532..586	CDD:302595
		PDZ_signaling	706..798	CDD:238492	25/100 (25%)
Tamalin	NP_062391.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		PDZ_signaling	99..184	CDD:238492	21/89 (24%)
		Interaction with PSCD3. /evidence=ECO:0000269\|PubMed:10828067	180..257		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910