DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prosap and shank3a

DIOPT Version :9

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:XP_017207498.1 Gene:shank3a / 557701 ZFINID:ZDB-GENE-060503-369 Length:1933 Species:Danio rerio


Alignment Length:2129 Identity:550/2129 - (25%)
Similarity:796/2129 - (37%) Gaps:774/2129 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PPPEPRDGWLLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKA 75
            |..||:...|:|||.:|:|...||::|..|..:|..||::|.:|.:.||:..|||||.|..||||
Zfish    86 PMEEPQGNTLVVRIGIPDLQQTKCMKFNVESPIWLSKQRILCTLNQSLKDVLNYGLFLPAYNGKA 150

  Fly    76 GKFLDEERRLGDYPFN--GPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVE 138
            ||||||:|.|.:||..  .||.|||.:||||||....|||:||..|||:|||::|:|.:...:||
Zfish   151 GKFLDEQRTLKEYPLPAVSPVPYLEFRYKRRVYTQAHLDEKQLSKLHTKANLKKFMEYVQQRNVE 215

  Fly   139 KIAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHD 203
            |::|...||||||:|..::|:.|||:|:..:...:|:..|.||||.||:||:||.||||:||...
Zfish   216 KVSKFLEKGLDPNYHDPDTGECPLTMASQLEGCAELIKVLKNGGAHLDFRTRDGITALHKAVRTK 280

  Fly   204 SLEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACR 268
            :..|:.|||:|||||:|:|.||:||||.|.....:....|.||||||.:|..|..||.|:|||||
Zfish   281 NHTALITLLDLGASPDYKDSRGLTPLYHSSMVGGDPYCCELLLHDHAQVGCMDENGWQEIHQACR 345

  Fly   269 HGLVQHLEHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAV 333
            ||.||||||||||||||..:|||||:.|||||:.||::|||:||||||.:..:|:.:||.:|||:
Zfish   346 HGHVQHLEHLLFYGADMSAQNASGNTALHVCALYNQDSCARVLLFRGANKEIKNYNSQTAFQVAI 410

  Fly   334 IAGNLELAEIIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSN 398
            ||||.:|||||:.:|:.|:||||..|.|..:||          ..|...|.::     .::..|.
Zfish   411 IAGNFDLAEIIKTHKASDVVPFRETPSYTNRRR----------VTGGDTLTSS-----RSLPRSA 460

  Fly   399 GAANGNNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQ--LHGPP 461
            ...|.||.|                    ...|.|             ..:|.|.:|.  .|...
Zfish   461 SDNNLNNVA--------------------DASHAH-------------SPVPSLRSLPPLAHSGI 492

  Fly   462 SPCPSEHMLGAYSSASSSLSEGS---------------SGHR------SHE----DDISIVTDKS 501
            .|...    |:..|..||||..|               :|.|      ||.    ...::..|.|
Zfish   493 DPAAD----GSLQSTGSSLSSHSRSPSLQRVTEEASVLAGRRHMPLMHSHSRGRLSPGTVQRDPS 553

  Fly   502 ---LGDTSDIISDSSGVGTNSDSAACSIGHPSTTVVCMEPYAGNTVGHIRLQPGDVI-------- 555
               :| .|..:|.:.|......||.     |..|.:.::||:....|.|:|..|:.:        
Zfish   554 PPPVG-PSHTLSGARGPKRKLYSAV-----PGRTFIVVKPYSPQGEGEIQLNRGERVKDYHSNAV 612

  Fly   556 ---------------------EVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKHITNVMT 599
                                 :|:...:.|..||.|:|  ::|:||||||:||.:||        
Zfish   613 EESPYVEHEIKEEDAHACVDDKVLSIGEGGFWEGTVKG--RTGWFPADCVEEVQMRQ-------- 667

  Fly   600 ASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQ 664
                                                          ..|.               
Zfish   668 ----------------------------------------------YDPR--------------- 671

  Fly   665 PLESNEGGASGNGINNRN----NNHSVGQYSSATAPRIKKSAY--NAPRSVVLHRAKRGFGFILR 723
             ||:.|         :||    .:::||.|.:.|:    .|.|  ....:::..:...||||:||
Zfish   672 -LETRE---------DRNKRLFRHYTVGSYDNFTS----YSDYIIEEKNAMLQKKENEGFGFVLR 722

  Fly   724 GAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRS 788
            ||||.:.:.:..|:..|||||||:.||..|||..||||.||||:.:||.:|....|:|||.:||.
Zfish   723 GAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVSLIRQ 787

  Fly   789 AGALVNLTVVSPQFPHQMQASAQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGP 853
            .|..:.:.|.|.                           ...|:|..    |:.:|         
Zfish   788 GGNSLLMKVASV---------------------------TRKPESEE----TVRKK--------- 812

  Fly   854 GSSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGLE-------NGGEKEDDLPHTKSNSVESI 911
                      ||.||:|.|.|||::   |:|||.|.||       ..||:.|::    ..|.|::
Zfish   813 ----------APPPPKRAPSTTLTL---RSKSMTAELEELASARRRRGERLDEI----LASQETV 860

  Fly   912 ATPTPTGIQTGPGTPVQLRTASIKARPTSSRITAAELEELFQRQ--------------------- 955
            ..|.         .....|.|::|.||||.|||.||:..||:||                     
Zfish   861 LRPK---------VEADYRAATVKQRPTSRRITPAEISSLFERQGLALHGALHPALEKAHMQLPK 916

  Fly   956 -----------QGEGSAANASRYATMMTSSRFQSGTDSGAATPPASNGSP-------MRSGP--- 999
                       :.:..:|.|:.:....:||...|..||.:..||.....|       :.:||   
Zfish   917 SMARTKSFGATEEDRLSALAAEHRFPRSSSMTDSLRDSHSIPPPPQMAPPPPPSLYYLDTGPPPS 981

  Fly  1000 ----------------------------LVYGSVAEM-----------KRKTARSK---HGSGTL 1022
                                        |.....||:           ::|.|||.   ..|..|
Zfish   982 FCPPPPPGRLHDPSRSSFKPGSEPRLHALPQTMSAELYEPPRHASHMERQKKARSMIILQDSSHL 1046

  Fly  1023 RGKPVATPTVGPGGAGGGRDLKR-------------------FHSTPDLHGPQLHGS-------- 1060
            ..:|...|..||......| :||                   |..||.  .||...|        
Zfish  1047 PVEPTDIPRPGPVSTPPER-IKRKGRIIDNPYANVGQFSVGMFTPTPS--KPQRRKSPLVKQLQV 1108

  Fly  1061 -----ASSIWQAS--GKGHHSQDDVATLHAS-------LQRLNSNQGELKLGGLGAGSATGAG-- 1109
                 .:|:..||  .:.|.....:|..|.|       .|:|...:.:....||..|....|.  
Zfish  1109 EDAQERASLALASIHAREHSPSGRLAAQHTSRSDFFHQQQQLLHERSQAHAEGLLQGKGPFAAAI 1173

  Fly  1110 ---------------------------GAVLPPPNHPP-------------------PPPPV--- 1125
                                       |:..|||..|.                   |||.:   
Zfish  1174 ADAVKDRERRLEERRKSTVFLSVGTMEGSSAPPPEAPSLTPSRSVDERMLTRELGQLPPPALALR 1238

  Fly  1126 ------------------------------------------------------GQVVKVETRSS 1136
                                                                  |.|:.:||::.
Zfish  1239 PSPGGTTFIHPLTGKPLDPNSPLALALAARERALTSQSQSPSSSPEPRTKHETAGGVLYMETQTK 1303

  Fly  1137 VSE--------------------YE-----------STISLQQKLKKRTE--------------- 1155
            .:|                    ||           |.||.:::|:.|||               
Zfish  1304 EAERSEGEGGFASPPFSPATKRIYETSVPTSKIQWGSPISTRKELETRTERKEERKIEDKKSMII 1368

  Fly  1156 ----NDAVTSAAIDGVQSSFN------------PSANAKIYASPQELRNVMAWKLRQAQEKPSQE 1204
                .....:|.:..|.::.|            ||....:..||:.    |..::::| :.|..|
Zfish  1369 SIMDTSQQKTAGLIMVHATSNGQAVGPSPERSVPSPKGILSESPKP----MLAEIKRA-KSPGPE 1428

  Fly  1205 TSAGSQQPVSQYAAPTQMRP-----------AQQQQQAQQ-----PPTALASHYAAPQVQVQQVQ 1253
            ..:.|..|.:  ||||...|           ...::.|:.     ||..|:|.....:.:::::.
Zfish  1429 APSISTPPPT--AAPTSQPPPSPSSDKTLAQGSSEEDAEPYTVTLPPAMLSSSDEETREELRKIG 1491

  Fly  1254 QVQQSPQQS------APQS--PPAPPLPQAAPVPAQNGNGNGSTSGAGSAPPIPEPDYSCSESDG 1310
            .|....:.|      .|::  ||||.|.|..|            |...||||.|.|         
Zfish  1492 VVPPPDEFSNGLLAKTPETAVPPAPTLTQTTP------------STLPSAPPAPPP--------- 1535

  Fly  1311 EDENSILVARNTKLNEKIALFDVPETSGNSQASG--SSSNSGSASISHSLSVEEIQRIRS---NL 1370
             ...|..||         |...||.:||...|||  |.|:.|..|.:.| .|||:....|   :|
Zfish  1536 -PAPSAAVA---------AAAQVPASSGLQAASGKPSESHLGPESAADS-GVEEVDTRSSSDHHL 1589

  Fly  1371 KTSK-----------SSPNG----------------FAKKPEEEKPQQEQQQSHQQPQQLLQPGE 1408
            :|:.           ||.:|                ..|.|...||:.:.|.| :.|.....|..
Zfish  1590 ETTSTISTVSSMSTLSSESGEPTDTYTTHADGQTFILDKPPVPPKPKLKSQLS-KGPVTFRDPLL 1653

  Fly  1409 DECDNSSSGVSSEQEQLALAAGVTLPGGGKPT-----------DTIKKKPSVTIVEEPKTIPDQP 1462
            .:  :|.|.:.|:|...||||.....|..:|.           ||::.:|.....|...|:..:.
Zfish  1654 KQ--SSDSELLSQQHAAALAAAAGASGPARPRYLFQRRSKLWGDTVEPRPLSGAEEGKPTVISEL 1716

  Fly  1463 SSNTSHTTKPMAKTTISIGG---GGSAVPTATLTVKQLVQQQHAPVIQQQQQQLGSKQPV----- 1519
            ||.    .:.:.|.|.|:|.   |.|..|                         |.|.||     
Zfish  1717 SSR----LQQLNKDTRSLGEEPLGASLDP-------------------------GRKSPVVGPRL 1752

  Fly  1520 --TAASTNKFTQQSNINSNVMSP----QVLGRIPSHHHQQQS------------SNPNQKLIATQ 1566
              :....:..:|:....:..:.|    .|..|.||.....:|            ::|     .|.
Zfish  1753 FSSLGELHTISQRGYGTTYTIRPGSRYPVTRRTPSPGSPDRSDPLGPIRGFGLATSP-----ITP 1812

  Fly  1567 QQILQQQQQQLAHQ-QHLQQILKAKAA---------AAGGASNTAVLVAKHQQKLHKGTSSGHES 1621
            ..||:.....|.|: :.::.::::.:|         :.|..|....|...||:.||         
Zfish  1813 PTILKSSSLSLPHEPKEVRFVMRSSSARSRSPSPAPSPGMTSPLLTLRPFHQKPLH--------- 1868

  Fly  1622 EMETRSDLEDDDGDLSPSPPAKAFQRHN-------SLTRKQAAAIAMQR 1663
             :..:.|:.|....::.:.....||.|.       :||::..|.:.:.|
Zfish  1869 -LWNKYDVGDWLASINLAEHRDRFQEHEIEGSHLPALTKEDYAELGVTR 1916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_f0 20..103 CDD:293120 43/84 (51%)
Ank_2 128..222 CDD:289560 46/93 (49%)
ANK 131..233 CDD:238125 51/101 (50%)
ANK repeat 157..189 CDD:293786 13/31 (42%)
ANK 186..312 CDD:238125 77/125 (62%)
ANK repeat 191..222 CDD:293786 18/30 (60%)
Ank_2 196..322 CDD:289560 76/125 (61%)
ANK repeat 224..289 CDD:293786 40/64 (63%)
ANK repeat 291..322 CDD:293786 19/30 (63%)
ANK repeat 324..353 CDD:293786 16/28 (57%)
SH3 532..586 CDD:302595 20/82 (24%)
PDZ_signaling 706..798 CDD:238492 41/91 (45%)
shank3aXP_017207498.1 FERM_f0 95..178 CDD:318667 42/82 (51%)
Ank_2 <202..>312 CDD:330894 55/109 (50%)
ANK 263..389 CDD:238125 77/125 (62%)
ANK repeat 268..299 CDD:293786 18/30 (60%)
ANK repeat 301..366 CDD:293786 40/64 (63%)
ANK 364..>427 CDD:238125 37/62 (60%)
ANK repeat 368..399 CDD:293786 19/30 (63%)
ANK repeat 401..426 CDD:293786 14/24 (58%)
SH3 580..660 CDD:327375 18/81 (22%)
PDZ_signaling 709..797 CDD:238492 41/87 (47%)
Atrophin-1 <1201..1525 CDD:331285 55/342 (16%)
SAM_Shank1,2,3 1866..1931 CDD:188905 11/61 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170582290
Domainoid 1 1.000 54 1.000 Domainoid score I11194
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 573 1.000 Inparanoid score I1015
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001441
OrthoInspector 1 1.000 - - otm25540
orthoMCL 1 0.900 - - OOG6_103134
Panther 1 1.100 - - O PTHR24135
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X750
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.980

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