| Sequence 1: | NP_610925.3 | Gene: | Prosap / 50225 | FlyBaseID: | FBgn0040752 | Length: | 1871 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_036441.2 | Gene: | SHANK2 / 22941 | HGNCID: | 14295 | Length: | 1849 | Species: | Homo sapiens |
| Alignment Length: | 2066 | Identity: | 525/2066 - (25%) |
|---|---|---|---|
| Similarity: | 784/2066 - (37%) | Gaps: | 687/2066 - (33%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 14 EPRDGWLLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKF 78
Fly 79 LDEERRLGDYPFNGPVG----YLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEK 139
Fly 140 IAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDS 204
Fly 205 LEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRH 269
Fly 270 GLVQHLEHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVI 334
Fly 335 AGNLELAEIIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNG 399
Fly 400 AANGNNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPC 464
Fly 465 PSEHMLGAY----SSASSSLSE----GSSGHRS----HEDDISIVTDKSLGDTSDIIS--DSSGV 515
Fly 516 GTNSDSAACSIGHPSTTVVCMEPYAGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFP 580
Fly 581 ADCVQEVSLRQKHITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLL 645
Fly 646 QQPHQSPSLSVASNGSCQQPLESNEGGASGNGINNRNNNHSVGQYSSATAPRIKKSAYNAPRSVV 710
Fly 711 LHRA-KRGFGFILRGAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDV 774
Fly 775 TSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQASAQYLPSGARAGSHHLNSGPSTPQSSHRQCA 839
Fly 840 TLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGLENGGEK-------- 896
Fly 897 --EDDLPHTK-SNSVESIATPTPTGIQTGPGTPVQLRTASIKARPTSSRITA-AELEELFQRQQG 957
Fly 958 EGSAANASRYATMMTSSRFQSGTDSGAATPPASNGSPMRSGPLVYGSVAEMKRKTARSKHGSGTL 1022
Fly 1023 RGKPVATPTVGPGGAGGGRDLK--RFHSTPDLHGPQLHGSASSIWQASGKGHHSQDDVATLHASL 1085
Fly 1086 QRLNSNQGELKLGGLGAGSATGAGGAVLPPPNHPPPPPPVGQVVKVETRSSVSEYESTI------ 1144
Fly 1145 SLQQKLKKRTENDAVTSA---------------AID---------GVQSSF---------NP--- 1173
Fly 1174 ---SANAKIY--ASPQELRNVMAWKLRQAQEKP--------------------SQETSAGSQQPV 1213
Fly 1214 SQYA--APTQMRPAQQQQQAQQPPTALASHYAAPQVQVQQVQQVQQSP--------QQSAPQSPP 1268
Fly 1269 AP------------------------PLPQAAP-VPAQNGNGNGSTSGAGSAPPIPEPDYSCSES 1308
Fly 1309 DGEDENSILVARNTKLNEKIALFDVPETSGNSQASGSSSNSGSASISHSLSVEEIQ--------- 1364
Fly 1365 --RIRSNLKTSKSSPNGFAKKPEEEKP----------------------------QQEQQQSHQQ 1399
Fly 1400 PQQLLQPGEDECDNSSSGVSSEQEQLALAAGVTLPGGGKPTDTIKKKPSVTIVE-----EPKTIP 1459
Fly 1460 D---------QPSSNTSHTTKPMAKTTISIGGGGSAV---------PTATL-------------- 1492
Fly 1493 -------------------TVKQLVQQQHAPVIQQQQQQLGSKQPVTAASTNKFTQQSN-INSNV 1537
Fly 1538 MSP-------------QVLGRIPSHHHQQQSSNPNQKLIATQQQILQQQQQQLAHQQHLQQILKA 1589
Fly 1590 KAAAAGG---------ASNTAVLV--------AKHQQKLHKGTSSGHESEMETRSDLEDDDGDLS 1637
Fly 1638 PSPPAKAFQRHNSLTRKQAAAIAMQRGATRTTAVSLMQLPPPLEADSDG-----EP--SQLTLQR 1695
Fly 1696 QQSHHPSQTHPHPHQLQQQLQLQQQQQQQQQQQ------QPMAAHIVGMLP-SGQLVAVASGAVA 1753
Fly 1754 GV------PGVGATAVQQGNNNLQQLCTDNLVLAPPPQFCDCNDAKHAPQP 1798 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Prosap | NP_610925.3 | FERM_f0 | 20..103 | CDD:293120 | 39/86 (45%) |
| Ank_2 | 128..222 | CDD:289560 | 49/93 (53%) | ||
| ANK | 131..233 | CDD:238125 | 55/101 (54%) | ||
| ANK repeat | 157..189 | CDD:293786 | 14/31 (45%) | ||
| ANK | 186..312 | CDD:238125 | 72/125 (58%) | ||
| ANK repeat | 191..222 | CDD:293786 | 18/30 (60%) | ||
| Ank_2 | 196..322 | CDD:289560 | 70/125 (56%) | ||
| ANK repeat | 224..289 | CDD:293786 | 36/64 (56%) | ||
| ANK repeat | 291..322 | CDD:293786 | 17/30 (57%) | ||
| ANK repeat | 324..353 | CDD:293786 | 18/28 (64%) | ||
| SH3 | 532..586 | CDD:302595 | 20/53 (38%) | ||
| PDZ_signaling | 706..798 | CDD:238492 | 47/92 (51%) | ||
| SHANK2 | NP_036441.2 | FERM_f0 | 57..140 | CDD:293120 | 38/84 (45%) |
| ANK repeat | 197..228 | CDD:293786 | 14/30 (47%) | ||
| Ank_2 | 201..295 | CDD:289560 | 44/93 (47%) | ||
| ANK | 225..351 | CDD:238125 | 72/125 (58%) | ||
| ANK repeat | 230..261 | CDD:293786 | 18/30 (60%) | ||
| ANK repeat | 263..328 | CDD:293786 | 36/64 (56%) | ||
| Ank_2 | 270..361 | CDD:289560 | 50/90 (56%) | ||
| ANK | 326..>387 | CDD:238125 | 36/60 (60%) | ||
| ANK repeat | 330..361 | CDD:293786 | 17/30 (57%) | ||
| SH3_Shank2 | 529..580 | CDD:212916 | 18/52 (35%) | ||
| PDZ_signaling | 624..717 | CDD:238492 | 47/92 (51%) | ||
| SAM_Shank1,2,3 | 1782..1847 | CDD:188905 | |||
| SAM | 1783..1849 | CDD:197735 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165148407 | |
| Domainoid | 1 | 1.000 | 54 | 1.000 | Domainoid score | I11217 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 515 | 1.000 | Inparanoid score | I1305 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | - | - | FOG0001441 | |
| OrthoInspector | 1 | 1.000 | - | - | otm42133 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_103134 | |
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3037 |
| SonicParanoid | 1 | 1.000 | - | - | X750 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 10 | 9.820 | |||||