Protein Alignment Prosap and SHANK2

DIOPT Version :10

• Sequence 1: NP_610925.3
• Gene: Prosap / 50225
• FlyBaseID: FBgn0040752
• Length: 1871
• Species: Drosophila melanogaster
• Sequence 2: NP_001427953.1
• Gene: SHANK2 / 22941
• HGNCID: 14295
• Length: 1889
• Species: Homo sapiens
• Alignment Length: 2083
• Identity: 524/2083 - (25%)
• Similarity: 783/2083 - (37%)
• Gaps: 681/2083 - (32%)

  Fly    14 EPRDGWLLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKF 78
            |.:...|::|:.:.:|...||::|..:..||..||::|.:|.:.||:..|||||.|.:||:.|||
Human    51 ESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKF 115

  Fly    79 LDEERRLGDYPFNGPVG----YLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEK 139
            |||||.|.:||  .|||    .||.:||:||||..:|||:||..|||:.||::.::.|....|||
Human   116 LDEERLLREYP--QPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEK 178

  Fly   140 IAKMCAKGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDS 204
            |.||..:|||||||..|:|:||||:|.......:::.||.||||.||:|.|||.||||:|....:
Human   179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARN 243

  Fly   205 LEAVSTLLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRH 269
            ..|:.|||||||||:|:|..|:||||.:.....:....|.|||:|||:..:|..||:|:|||||:
Human   244 QVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRY 308

  Fly   270 GLVQHLEHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVI 334
            |.||||||||||||||..:|||||:.||:||:.||::|||:|||||..:..:|:.:|||:|||:|
Human   309 GHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAII 373

  Fly   335 AGNLELAEIIENYKSEDIVP--------FRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFG 391
            |||.||||.|:|:|..||||        |..||.   ..|..|||..:........|......|.
Human   374 AGNFELAEYIKNHKETDIVPLVPTRRRVFGAPPL---SHRPAIGWAQSCNLDEPTGLFPPAPRFH 435

  Fly   392 GAMVGSNGAANG------------------NNGAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQ 438
            ....|......|                  |..|....|:.|:.::..:.:............|:
Human   436 RTCSGEQSHWTGSVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHR 500

  Fly   439 NHHQQLQQQQLPHLHTLQLHGPPSPCPSEHMLGAY----SSASSSLSE----GSSGHRS----HE 491
            :...||.||.           |..|..:...:|:|    .|.|.||:.    |..|.|.    |
Human   501 SLSPQLLQQM-----------PSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWH- 553

  Fly   492 DDISIVTDKSLGDTSDIIS--DSSGVGTNSDSAACSIGHPSTTVVCMEPYAGNTVGHIRLQPGDV 554
                :.:..:||...|.:|  :..|......||.     |....|.::||.....|.|.|..||.
Human   554 ----VGSPFALGANKDSLSAFEYPGPKRKLYSAV-----PGRLFVAVKPYQPQVDGEIPLHRGDR 609

  Fly   555 IEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKHITNVMTASTGMAPQQQQQQHLQQAPA 619
            ::|:...:.|..||..||  ..|:|||:||:||                           |..|.
Human   610 VKVLSIGEGGFWEGSARG--HIGWFPAECVEEV---------------------------QCKPR 645

  Fly   620 GSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQPLESNEGGASGNGINNRNNN 684
            .|.|.:           .:..|..|.:                                     :
Human   646 DSQAET-----------RADRSKKLFR-------------------------------------H 662

  Fly   685 HSVGQYSSATAPRIKKSAYNAPRSVVLHRA-KRGFGFILRGAKASSQLMQLRPSERFPALQYLDD 748
            ::||.|.|...   ........::|||.:. ..||||:||||||.:.:.:..|:..|||||||:.
Human   663 YTVGSYDSFDT---SSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLES 724

  Fly   749 VDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQASAQYL 813
            ||.||||..||||.||||:.:|.|:|....|.|||.|||..|..:.|.||
Human   725 VDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVV--------------- 774

  Fly   814 PSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDPKTTLSV 878
                                      |:.|.:      .|..::.   :.||.||:|.|.|.|::
Human   775 --------------------------TVTRNL------DPDDTAR---KKAPPPPKRAPTTALTL 804

  Fly   879 GRARAKSMVAGLENGGEKEDDLPHTK-SNSVESIATPTPTGIQTGPGTPVQLRTASIKARPTSSR 942
               |:|||.:.||...:.|:.:|.:| |.:.|::|              |:.|.|:||.||:|..
Human   805 ---RSKSMTSELEELDKPEEIVPASKPSRAAENMA--------------VEPRVATIKQRPSSRC 852

  Fly   943 ITA-AELEELFQRQQGEGSAANASRYATMMTSSRFQSGTDSGAATPPASNGSPMRSGPLVYGSVA 1006
            ..| :::..:::||   |.|        :||            .|.|.|..:|....|
Human   853 FPAGSDMNSVYERQ---GIA--------VMT------------PTVPGSPKAPFLGIP------- 887

  Fly  1007 EMKRKTARSKHGSG-TLRGKPVATPTVGPGGAGGGRDLK--RFHSTPDLHGPQLHGSASSIWQAS 1068
               |.|.|.:...| |...:....|.:          ||  |..|.||
Human   888 ---RGTMRRQKSIGITEEERQFLAPPM----------LKFTRSLSMPD----------------- 922

  Fly  1069 GKGHHSQDDVATLHASLQRLNSNQGELKLGGLGAGSATGAGGAVLPPPNHPPPPPPVGQVVKVET 1133
                 :.:|:..                                 ||.:.||.|||.........
Human   923 -----TSEDIPP---------------------------------PPQSVPPSPPPPSPTTYNCP 949

  Fly  1134 RSSVSEYESTI------SLQQKLKKRTENDAVTSA---------------AID---------GVQ 1168
            :|.......||      :...|:...|.:|.|.:.               ::|         |.|
Human   950 KSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYSLDSEDLYSRNAGPQ 1014

  Fly  1169 SSF---------NP------SANAKIY--ASPQELRNVMAWKLRQAQEKP--------------- 1201
            ::|         ||      .|:..:|  |.|.. |..|..|....::.|
Human  1015 ANFRNKRGQMPENPYSEVGKIASKAVYVPAKPAR-RKGMLVKQSNVEDSPEKTCSIPIPTIIVKE 1078

  Fly  1202 -----SQETSAGSQQPVSQYA--APTQMRPAQQQQQAQQPPTALASHYAAPQVQVQQVQQVQQSP 1259
                 |.::|.||...:...|  .|:|:||.:....:.....|:|   .|.:.:.::::..:.||
Human  1079 PSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAAAIA---GAVRDREKRLEARRNSP 1140

  Fly  1260 --------QQSAPQSPPAP------------------------PLPQAAP-VPAQNGNGNGSTSG 1291
                    .:.....||||                        |:|.|.| .|..:..|....|.
Human  1141 AFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQLSSPMPSATPREPENHFVGGAEASA 1205

  Fly  1292 AGSAPPIPEPDYSCSESDGEDENSILVARNTKLNEKIALFDVPETSGNSQASGSSSNSGSASISH 1356
            .|.|   ..|..|.|::.|                       ||:| .:..|.||..:|..:..|
Human  1206 PGEA---GRPLNSTSKAQG-----------------------PESS-PAVPSASSGTAGPGNYVH 1243

  Fly  1357 SLSVEEIQ-----------RIRSNLKTSKSSPNGFAKKPEEEKP--------------------- 1389
            .|:...:.           |.|: :|.|:..|.|.|.|.:..||
Human  1244 PLTGRLLDPSSPLALALSARDRA-MKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFPTVTRQ 1307

  Fly  1390 -------QQEQQQSHQQPQQLLQPGEDECDNSSSGVSSEQEQLALAAGVTLPGGGKPTDTIKKKP 1447
                   :||.:..::......:.|:|:.:.....:.:.|::.|....|......|..:.::::.
Human  1308 NTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVDATKLDNALQEED 1372

  Fly  1448 SVTIVE-----EPKTIPD---------QPSSNTSHTTKPMAKTTISIGGGGSAV---------PT 1489
            ....||     .|..:|:         |.|:....||.| .:|.:::|....||         |.
Human  1373 EKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVP-GRTIVAVGSMEEAVILPFRIPPPPL 1436

  Fly  1490 ATL---------------------------------TVKQLVQQQHAPVIQQQQQQLGSKQPVTA 1521
            |::                                 .:..||:|:.:..  .|...|.|.||..:
Human  1437 ASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQKKSDT--PQSPSLNSSQPTNS 1499

  Fly  1522 ASTNKFTQQSN-INSNVMSP-------------QVLGRIPSHHHQQQSSNPNQKLIATQQQILQQ 1572
            |.:.|....|| :.::.:.|             :|..|..|.||.:.:|.     |:|...|
Human  1500 ADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSSDHHLETTST-----ISTVSSI--- 1556

  Fly  1573 QQQQLAHQQHLQQILKAKAAAAGG---------ASNTAVLV--------AKHQQKLHKGTSSGHE 1620
                            :..::.||         |...|.:|        .|.:..:||..:...:
Human  1557 ----------------STLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNALYQD 1605

  Fly  1621 SEMETRSDLEDDDGDLSPSPPAKAFQRHNSLTRKQAAAIAMQRGATRTTAVSLMQLPPPLEADSD 1685
            :.:|     ||.|..:.| |||.                                 |||..:...
Human  1606 ALVE-----EDVDSFVIP-PPAP---------------------------------PPPPGSAQP 1631

  Fly  1686 G-----EP--SQLTLQRQQSHHPSQTHPHPHQLQQQLQLQQQQQQQQQQQ------QPMAAHIVG 1737
            |     :|  |:|.....:...|..:.|..:.:.:...:.||..:::..:      .||.|....
Human  1632 GMAKVLQPRTSKLWGDVTEIKSPILSGPKANVISELNSILQQMNREKLAKPGEGLDSPMGAKSAS 1696

  Fly  1738 MLP-SGQLVAVASGAVAGV------PGVGATAVQQGNNNLQQLCTDNLVLAPPPQFCDCNDAKHA 1795
            :.| |.::::..||..:..      ||.......|..              ||......:..:.|
Human  1697 LAPRSPEIMSTISGTRSTTVTFTVRPGTSQPITLQSR--------------PPDYESRTSGTRRA 1747

  Fly  1796 PQP 1798
            |.|
Human  1748 PSP 1750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_F0_SHANK	20..103	CDD:340611	39/86 (45%)
		ANKYR	109..348	CDD:440430	132/238 (55%)
		ANK repeat	157..189	CDD:293786	14/31 (45%)
		ANK repeat	191..222	CDD:293786	18/30 (60%)
		ANK repeat	224..289	CDD:293786	36/64 (56%)
		ANK repeat	291..322	CDD:293786	17/30 (57%)
		ANK repeat	324..353	CDD:293786	18/28 (64%)
		SH3	532..586	CDD:473055	20/53 (38%)
		PDZ_SHANK1_3-like	703..800	CDD:467228	49/97 (51%)
SHANK2	NP_001427953.1	None