DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prosap and Cytip

DIOPT Version :9

Sequence 1:	NP_610925.3	Gene:	Prosap / 50225	FlyBaseID:	FBgn0040752	Length:	1871	Species:	Drosophila melanogaster
Sequence 2:	NP_631939.1	Gene:	Cytip / 227929	MGIID:	2183535	Length:	359	Species:	Mus musculus

Alignment Length:	382	Identity:	90/382 - (23%)
Similarity:	149/382 - (39%)	Gaps:	87/382 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   658 SNGSCQQPLESNEGGAS---GNGINNRNNNHSVGQYSSATAPRIKKS------------AYNAPR 707
            |||:.:...:|..|..|   |......|....|...:.||.||.:|.            :::..:
Mouse    12 SNGNLEYCADSAYGSYSVLTGQLTMEDNRRIQVLADTVATLPRGRKQLALARSSSLGDFSWSQRK 76

  Fly   708 SVVLHRAKRG-FGFILRGAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTING 771
            .|.:.:...| |||.::..:..:|  .:..||....:..:.:..|   |..|||:.||....:||
Mouse    77 VVTVEKQDNGTFGFEIQTYRLQNQ--NICSSEVCTMICKVQEDSP---AHCAGLQVGDIFANVNG 136

  Fly   772 EDVTSASHEQVVEMIRSAGALVNLTVVSPQFPH---QMQASAQYLPSGARAGSHHLNSGPSTPQS 833
            ......:|:|||::|||:|.|:.:..::....|   :::|..|.|....:.....|       :|
Mouse   137 VSTEGFTHKQVVDLIRSSGNLLTIETLNGTMIHRRAELEAKLQTLKQTLKKKWVEL-------RS 194

  Fly   834 SHRQCATLPRKMTGPGGSGPG--------SSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGL 890
            .|.|   ..|.:.|...:.|.        ||..|:: :.|.|...| :..|| ..:..||.::.|
Mouse   195 LHLQ---EQRLLHGDTANSPNLENMDLDESSLFGNL-LGPSPALLD-RHRLS-SESSCKSWLSSL 253

  Fly   891 ENGGEKEDDLPHTKSNSVESIATPTPTGIQTGPGTPVQLRTASIKARPTSSRITAAELEELFQRQ 955
            .  .:.||.  :..|.|.:||                         |...||.|:.: :|.|..:
Mouse   254 T--VDSEDG--YRSSMSEDSI-------------------------RGAFSRQTSTD-DECFHSK 288

  Fly   956 QGEGSAANASRYATMMTSSRFQSGTDSGAATPP-ASNGSPMRSGPLVYGSVAEMKRK 1011
            .|:....|||     ...:|..|.|.||:.:|. .||.|.      |:|::....|:
Mouse   289 DGDEILRNAS-----SRRNRSISVTSSGSFSPLWESNYSS------VFGTLPRKSRR 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_f0	20..103	CDD:293120
		Ank_2	128..222	CDD:289560
		ANK	131..233	CDD:238125
		ANK repeat	157..189	CDD:293786
		ANK	186..312	CDD:238125
		ANK repeat	191..222	CDD:293786
		Ank_2	196..322	CDD:289560
		ANK repeat	224..289	CDD:293786
		ANK repeat	291..322	CDD:293786
		ANK repeat	324..353	CDD:293786
		SH3	532..586	CDD:302595
		PDZ_signaling	706..798	CDD:238492	26/92 (28%)
Cytip	NP_631939.1	PDZ_signaling	76..161	CDD:238492	26/89 (29%)
Cytip	NP_631939.1	Interaction with CYTH1. /evidence=ECO:0000250	166..188		4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910