DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prosap and Shank2

DIOPT Version :9

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:XP_006508582.1 Gene:Shank2 / 210274 MGIID:2671987 Length:1912 Species:Mus musculus


Alignment Length:2086 Identity:528/2086 - (25%)
Similarity:778/2086 - (37%) Gaps:681/2086 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKFLDEERR 84
            |::|:.:.:|...||::|..:..||..||::|.:|.:.||:..|||||.|.:||:.||||||||.
Mouse    57 LVIRVVIQDLQQTKCIRFNPDATVWVAKQRILCTLNQGLKDVLNYGLFQPASNGRDGKFLDEERL 121

  Fly    85 LGDYPF-NGP-VGYLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEKIAKMCAKG 147
            |.:||. .|| |..||.:||:||||...|||:||..|||:.||::|::......|||:||:..:|
Mouse   122 LREYPQPMGPGVPSLEFRYKKRVYKQSNLDEKQLARLHTKTNLKKFMDHAQHRSVEKLAKLLDRG 186

  Fly   148 LDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVSTLL 212
            ||||||..|:|:||||:|.......:::.||.||||.||:|::||.||||:|....:..|:.|||
Mouse   187 LDPNFHDLETGETPLTLAAQLDDSMEVIKALRNGGAHLDFRSRDGMTALHKAARMRNQVALKTLL 251

  Fly   213 ELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRHGLVQHLEH 277
            ||||||:|:|..|:||||.:.....:....|.|||:||::..:|..||:|:|||||:|.||||||
Mouse   252 ELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHASVCCKDENGWHEIHQACRYGHVQHLEH 316

  Fly   278 LLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVIAGNLELAE 342
            ||||||||..:|||||:.||:||:.||::|||:|||||..:..:|:.:|||:|||:||||.||||
Mouse   317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAIIAGNFELAE 381

  Fly   343 IIENYKSEDIVPF---RGPPRYNP--KRRSGIGWLSANGAAGAALLAAAGGGFGGAMVG------ 396
            .|:|:|..||||.   |.|....|  ..|..:||..:......|.|.....||.....|      
Mouse   382 YIKNHKETDIVPLAPTRRPISGAPPCSHRPTMGWAQSCTVDEPAGLRPPALGFHRTCSGEQPHWT 446

  Fly   397 -----------SNGAANGNNGAGGVGLMLSHQNHQQHHAGHHQQQHMH-HQHHQNHHQQLQQQQL 449
                       ||......|......::|...:....:||..:..... ...|::...||.||. 
Mouse   447 GSVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNAGAPEWAVCSAATSHRSLSPQLLQQT- 510

  Fly   450 PHLHTLQLHGPPSPCPSEHMLGAYSSASSSLSEGSSGHRSHEDDISIVTDKSLGDTSD------- 507
                      |..|..:...||:|          :.|.||....::     .||.|::       
Mouse   511 ----------PSKPDGATKSLGSY----------TPGPRSRSPSLN-----RLGGTAEDGKRTQP 550

  Fly   508 --IISDSSGVGTNSDSAA----------CSIGHPSTTVVCMEPYAGNTVGHIRLQPGDVIEVVGS 560
              .:......|.|.||.:          .....|....|.::||.....|.|.|..||.::|:..
Mouse   551 HWHVGSPFTPGANKDSLSTFEYPGPRRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSI 615

  Fly   561 TDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKHITNVMTASTGMAPQQQQQQHLQQAPAGSSAAS 625
            .:.|..||..||  ..|:|||:||:||                           |..|..|.|.:
Mouse   616 GEGGFWEGSARG--HIGWFPAECVEEV---------------------------QCKPRDSQAET 651

  Fly   626 YQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQPLESNEGGASGNGINNRNNNHSVGQY 690
                       .:..|..|.:                                     :::||.|
Mouse   652 -----------RADRSKKLFR-------------------------------------HYTVGSY 668

  Fly   691 SSATAPRIKKSAYNAPRSVVLHRA-KRGFGFILRGAKASSQLMQLRPSERFPALQYLDDVDPGGV 754
            .|..|   ........::|||.:. ..||||:||||||.:.:.:..|:..|||||||:.||.|||
Mouse   669 DSFDA---ASDCIIEDKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGV 730

  Fly   755 ADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQASAQYLPSGARA 819
            |..||||.||||:.:|.|:|....|.|||.|||..|..:.|.||                     
Mouse   731 AWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLILKVV--------------------- 774

  Fly   820 GSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDPKTTLSVGRARAK 884
                                |:.|.:      .|..::.   :.||.||:|.|.|.|::   |:|
Mouse   775 --------------------TVTRNL------DPDDTAR---KKAPPPPKRAPTTALTL---RSK 807

  Fly   885 SMVAGLENGG---------EKEDDLPHTKSNSVESIATPTPTGIQTGPGTPVQLRTASIKARPTS 940
            ||.|.||..|         .|:.|.|.      |.:....|:  :|.....::.|.|:||.||||
Mouse   808 SMTAELEELGLSLVDKASVRKKKDKPE------EIVPASKPS--RTAENVAIESRVATIKQRPTS 864

  Fly   941 SRITAA-ELEELFQRQQGEGSAANASRYATMMTSSRFQSGTDSGAATPPASNGSPMRSGP---LV 1001
            ....|| ::..:::||   |.|        :||               |...|||  .||   |.
Mouse   865 RCFPAASDVNSVYERQ---GIA--------VMT---------------PTVPGSP--KGPFLGLP 901

  Fly  1002 YGSVAEMKRKTARSKHGSGTLRGKPVATPTVGPGGAGGGRDLK--RFHSTPDLHGPQLHGSASSI 1064
            .|::...|...:|......|...:....|.:          ||  |..|.||             
Mouse   902 RGTMRRQKSIDSRIFLSGITEEERQFLAPPM----------LKFTRSLSMPD------------- 943

  Fly  1065 WQASGKGHHSQDDVATLHASLQRLNSNQGELKLGGLGAGSATGAGGAVLPPPNHPPPPPPVGQVV 1129
                     :.:|:..                                 ||.:.||.|||.....
Mouse   944 ---------TSEDIPP---------------------------------PPQSVPPSPPPPSPTT 966

  Fly  1130 KVETRSSVSEYESTIS-------LQQKLKKRTENDAVTSA---------------AID------- 1165
            ....||.......||.       :..|:...|.:|.|.:.               ::|       
Mouse   967 YNCPRSPTPRVYGTIKPAFNQNPVVAKVPPATRSDTVATMMREKGMFYRRELDRFSLDSEDVYSR 1031

  Fly  1166 --GVQSSF---------NP------SANAKIY--ASPQELRNVMAWKLRQAQEKP---------- 1201
              ..|::|         ||      .|:..:|  |.|...:.|:. |....::.|          
Mouse  1032 SPAPQAAFRTKRGQMPENPYSEVGKIASKAVYVPAKPARRKGVLV-KQSNVEDSPEKTCSIPIPT 1095

  Fly  1202 ----------SQETSAGSQQPVS-QYAAPTQMRPAQQQQQAQQPPTALASHYAAPQVQVQQVQQV 1255
                      |.::|.||...:. |...|.|:||......:.....|:|   .|.:.:.::::..
Mouse  1096 IIVKEPSTSSSGKSSQGSSMEIDPQATEPGQLRPDDSLTVSSPFAAAIA---GAVRDREKRLEAR 1157

  Fly  1256 QQSP--------QQSAPQSPPAPPLPQAAPVPAQNGNGNGSTSGAGSAPPIPEPDYSCSE----- 1307
            :.||        .:.....||||.: ||:..|.:.|.|:...:   ..|.:|.|..:..|     
Mouse  1158 RNSPAFLSTDLGDEDVGLGPPAPRM-QASKFPEEGGFGDEDET---EQPLLPTPGAAPRELENHF 1218

  Fly  1308 -------SDGEDENSILVARNTKLNEKIALFDVPETSGNSQASGSSSNSGSASISHSLSVEEIQ- 1364
                   :.||....:......|         .|| ||.:....|||.:|..:..|.|:...:. 
Mouse  1219 LGGGEAGAQGEAGGPLSSTSKAK---------GPE-SGPAAPLKSSSPAGPENYVHPLTGRLLDP 1273

  Fly  1365 ----------RIRSNLKTSKSSPNGFAKKPEEEKP----------------------------QQ 1391
                      |.|: ::.|:....|.|.|.:..||                            :|
Mouse  1274 SSPLALALSARDRA-MQESQQGHKGEAPKADLNKPLYIDTKMRPSVESGFPPVTRQNTRGPLRRQ 1337

  Fly  1392 EQQQSHQQPQQLLQPGEDECDNSSSGVSSEQEQ---LALAAGVTLPGGGKPT---------DTIK 1444
            |.:..::......:..:|:.:...:.|.:.|::   |.:...|.:|..|.|.         ||  
Mouse  1338 ETENKYETDLGKDRRADDKKNMLINIVDTAQQKSAGLLMVHTVDVPMAGPPLEEEEDREDGDT-- 1400

  Fly  1445 KKPSVTIVEEPKTIPD---------QPSSNTSHTTKPMAKTTISIGGGGSAV---------PTAT 1491
             ||.    ..|.|:|:         |.|:.......| .:|.::.|....||         |.|:
Mouse  1401 -KPD----HSPSTVPEGVPKTEGALQISAAPEPAVAP-GRTIVAAGSVEEAVILPFRIPPPPLAS 1459

  Fly  1492 LTVKQ---------------------------------LVQQQHAPVIQQQQQQLGSKQPVTAAS 1523
            :.:.:                                 ||:|:....  .|...|.|.||..:..
Mouse  1460 VDLDEDFLFTEPLPPPLEFANSFDIPDDRAASVPALADLVKQKKNDT--SQPPTLNSSQPANSTD 1522

  Fly  1524 TNKFTQQSN-INSNVMSP-------------QVLGRIPSHHHQQQSSNPNQKLIATQQQILQQQQ 1574
            :.|....|| :.|:.:.|             :|..|..|.||.:.:|.     |:|...|     
Mouse  1523 SKKPAGISNCLPSSFLPPPESFDAVTDSGIEEVDSRSSSDHHLETTST-----ISTVSSI----- 1577

  Fly  1575 QQLAHQQHLQQILKAKAAAAGGAS-NTAVLVA----------------KHQQKLHKGTSSGHESE 1622
                          :..::.||.| :|..:.|                |.:..:||..:...::.
Mouse  1578 --------------STLSSEGGESMDTCTVYADGQAFVVDKPPVPPKPKMKPIVHKSNALYQDTL 1628

  Fly  1623 METRSDLEDDDGDL----SPSPP--------AKAFQRHNS-------------LTRKQAAAIA-- 1660
            .|     ||.||.:    :|.||        ||..|...|             |:..:|..|:  
Mouse  1629 PE-----EDTDGFVIPPPAPPPPPGSAQAGVAKVIQPRTSKLWGDVPEVKSPILSGPKANVISEL 1688

  Fly  1661 ------MQRG--------------------------------ATRTTAV------------SLMQ 1675
                  |.||                                .||:|.|            :|..
Mouse  1689 NSILQQMNRGKSVKPGEGLELPVGAKSANLAPRSPEVMSTVSGTRSTTVTFTVRPGTSQPITLQS 1753

  Fly  1676 LPPPLEADSDG---EPSQLTLQRQQSHHPSQTHPHPHQLQQQLQLQQQQQQQQQQQQPMAAHIVG 1737
            .||..|:.:.|   .||.:....:.|.....|.|.|...................|.| |..:.|
Mouse  1754 RPPDYESRTSGPRRAPSPVVSPTELSKEILPTPPPPSATAASPSPTLSDVFSLPSQSP-AGDLFG 1817

  Fly  1738 MLPSGQ 1743
            :.|:|:
Mouse  1818 LNPAGR 1823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_f0 20..103 CDD:293120 39/84 (46%)
Ank_2 128..222 CDD:289560 47/93 (51%)
ANK 131..233 CDD:238125 52/101 (51%)
ANK repeat 157..189 CDD:293786 14/31 (45%)
ANK 186..312 CDD:238125 70/125 (56%)
ANK repeat 191..222 CDD:293786 18/30 (60%)
Ank_2 196..322 CDD:289560 69/125 (55%)
ANK repeat 224..289 CDD:293786 35/64 (55%)
ANK repeat 291..322 CDD:293786 17/30 (57%)
ANK repeat 324..353 CDD:293786 18/28 (64%)
SH3 532..586 CDD:302595 20/53 (38%)
PDZ_signaling 706..798 CDD:238492 47/92 (51%)
Shank2XP_006508582.1 Ubiquitin_like_fold 55..142 CDD:391949 39/84 (46%)
PHA03095 164..>371 CDD:222980 108/206 (52%)
ANK repeat 197..228 CDD:293786 14/30 (47%)
ANK repeat 230..261 CDD:293786 18/30 (60%)
ANK repeat 263..328 CDD:293786 35/64 (55%)
ANK repeat 330..361 CDD:293786 17/30 (57%)
SH3_Shank2 586..637 CDD:212916 18/52 (35%)
PDZ_signaling 682..774 CDD:238492 47/91 (52%)
PHA03247 <1129..1538 CDD:223021 78/436 (18%)
SAM_Shank1,2,3 1845..1910 CDD:188905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838526
Domainoid 1 1.000 54 1.000 Domainoid score I11171
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 406 1.000 Inparanoid score I1870
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001441
OrthoInspector 1 1.000 - - otm44187
orthoMCL 1 0.900 - - OOG6_103134
Panther 1 1.100 - - O PTHR24135
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3037
SonicParanoid 1 1.000 - - X750
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.920

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