DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prosap and shn-1

DIOPT Version :9

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:NP_001379494.1 Gene:shn-1 / 174739 WormBaseID:WBGene00006444 Length:1140 Species:Caenorhabditis elegans


Alignment Length:1528 Identity:378/1528 - (24%)
Similarity:575/1528 - (37%) Gaps:538/1528 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKFLDEERRLG 86
            ::|.||||||.|.|.......:||||:::||:||:.|.::||||||.||.:|:|||||.|:|.:.
 Worm    10 LQIFVPELNVRKFLAVTQNDFIWDVKRKLLATLPQALPQAFNYGLFLPPCDGRAGKFLLEDRTIR 74

  Fly    87 DYPFNGPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEKIAKMCAKGLDPN 151
            ||||...|.|||||||:||||||.|||:||||:||:..|::|::.:...:.||:.|||::|||.|
 Worm    75 DYPFTDCVPYLELKYKK
RVYKMLNLDEKQLKAMHTKGQLKKFMDYVQQKNNEKVEKMCSQGLDAN 139

  Fly   152 FHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVSTLLELGA 216
            ||.:: |:||||:|.|......::::|:.|||.:|:|..:|.||:|:|....|.|.|.||:||||
 Worm   140 FHDAQ-GETPLTLAAGIPNNRAVIVSLIGGGAHVDFRNSEGQTAMHKAAFLSSFENVKTLIELGA 203

  Fly   217 SPNYRDGRGITPLYIS-ITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRHGLVQHLEHLLF 280
            ||||||..|:||||.: :|.....::.|.||.:.|.:|:.|..|.:|:||||::||.:|:||||:
 Worm   204 SPNYRDPIGLTPLYYNMLTADSNDQVAEILLREAADIGVTDMHGNHEIHQACKNGLTKHVEHLLY 268

  Fly   281 YGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVIAGNLELAEIIE 345
            :|..:|..|.:||||||||||||:..|||:||||||...|.|...||...|:.|.||..:|::::
 Worm   269 FGGQIDAENVNGNSPLHVCAVNNRPECARVLLFRGADHLAVNKQGQTAL
HVSHIVGNPGVADVVQ 333

  Fly   346 NYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNGAANGNNGAGGV 410
            .:..:..||:||.|:|:.:||                                            
 Worm   334 AHNPKSSVPYRGTPQYSTRRR-------------------------------------------- 354

  Fly   411 GLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPCPSEHMLGAYSS 475
                                                                             
 Worm   355 ----------------------------------------------------------------- 354

  Fly   476 ASSSLSEGSSGHRSHEDDISIVTDKSLGDTSDIISDSSGVGTNSDSAACSIGHPSTTVVCMEPYA 540
                ||...:..||                            .|.|:.||               
 Worm   355 ----LSSTITRRRS----------------------------MSQSSICS--------------- 372

  Fly   541 GNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKHITNVMTASTGMA 605
                                                        |:|.               ..
 Worm   373 --------------------------------------------QDVY---------------RT 378

  Fly   606 PQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVASNGSCQQP-LESN 669
            ||..::..:..||:.|.               |.||.|.:     :||    ..|:.::. ::|.
 Worm   379 PQSVRKGPMSAAPSPSP---------------SRSSRTTI-----TPS----EYGTMRRSGMDSM 419

  Fly   670 EGG---ASGNGINNRNNNHSVGQYSSATAPRIKKSAYNAPRSVVLHRAKRGFGFILRGAKASSQL 731
            .||   |:|         |..                |..|.:|:.|..:||||||||||..:..
 Worm   420 RGGGMIAAG---------HET----------------NIARILVIPRGVKGFGFILRGAKHVAMP 459

  Fly   732 MQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLT 796
            :...|:.:.||||:.:.||..|:|..|||||||:||.|:|.||...||::|||.|:.||..:.|.
 Worm   460 LNFEPTAQVPALQFFEGVDMSGMAVRAGLRPGDYLLEIDGIDVRRCSHDEVVEFIQQAGDTITLK 524

  Fly   797 VVSPQFPHQMQASAQYLPSGARAGS--HHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGG 859
            |::..           :...:|.|:  |.    |.|..|.|....|       |..|...||:..
 Worm   525 VITVD-----------VADMSRGGTIVHR----PPTASSRHSLVFT-------PTPSAIYSSTKA 567

  Fly   860 SVRMAPMPPRRDPKTTLSVGRARAKSMVA-GLENGGEKEDDLPHTKSNSVESIATPTPTGIQTGP 923
            |                ||.|.|..:..| |::.....|....:::|                  
 Worm   568 S----------------SVYRMRFDTHDAHGVDYYAPNEIRNAYSES------------------ 598

  Fly   924 GTPVQLRTASIKARPTSS-RITAAELEELFQRQQGEGSAANASRYATMMTSSRFQSGTDSGAATP 987
                  |.||::.||.|. ||:|||||.|..||:                              .
 Worm   599 ------RHASVRQRPGSGRRISAAELENLMVRQR------------------------------V 627

  Fly   988 PASNGSPMRSGPLVYGSVAEMKRKTARSKHGSGTLRGKPVATPTVGPGGAGGGRDLKRFHSTPDL 1052
            |:..|||.:   :.|...:                              ..||...|:::|..|:
 Worm   628 PSVQGSPYQ---MQYDQES------------------------------LNGGYSSKKYNSVSDM 659

  Fly  1053 HGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRLNSNQGELKLGGLGAGSATGAGGAVLPPPN 1117
              .:..|..:.:..::|....:.:..|...::.:...|::...:|..:.:..:       ....:
 Worm   660 --KRRKGQRNVVASSAGLNRSTFEQAAPTTSTFEYNCSSRSTPQLSRMDSFDS-------FDDED 715

  Fly  1118 HPPPPPPVGQVVKVETRSSVSEYESTISLQQKLKKRTENDAVTSAAIDGVQSSFNPSANAKIYAS 1182
            ..|.|||...:.....|.|        |:|:....|                .|.|::..|....
 Worm   716 EMPAPPPASYISPDLQRDS--------SMQRSEYSR----------------PFRPTSRPKTPPP 756

  Fly  1183 PQELRNVMAWKLRQAQEKPSQETSAGSQQPVSQYAAPTQMRPAQQQQQAQQPPTALASHYAAPQV 1247
            |..:::......:..|:.||...||.:.||:.|          ||......||.....|.....|
 Worm   757 PPPMQHQNHQNHQYQQQHPSLPRSASTPQPIQQ----------QQSSIPPPPPPPPPPHCEPTMV 811

  Fly  1248 QVQQVQQVQQSPQQSA--PQSPPAPPLPQAAPVPAQNGNGNGSTSGAGSAPPIPEPDYSCSESDG 1310
            .|:..     .|..|:  |..||.||:...||.|.......|....|.|||.:      .|.|.|
 Worm   812 HVEFT-----PPSTSSVPPPPPPLPPISSGAPPPPPPPPPGGLMHVAASAPVL------MSNSKG 865

  Fly  1311 EDENSILVARNTKLNEKIALFDVPETSGNSQASGSSSNSGS----------------ASISHSLS 1359
            ...:::...:..|...:       |||..|.::.:::|:.|                :.::|.:.
 Worm   866 ISADALKSVQLKKAEPR-------ETSAASVSNNNNNNNNSTTDFQMDLKNALAKRRSKVAHDVD 923

  Fly  1360 VEEIQRIR---------------------SNLKTSKSSPNGFAKKPEEEKPQQEQQQSHQ----- 1398
            .:|.:..|                     .|:.......:|:.......:|.:.:::.|:     
 Worm   924 EDEERESRFEGLSLRETVRENVVERGKGIQNIGIVNKKDSGYTSSRTSLEPSESEEKDHRPHFSL 988

  Fly  1399 --QP--------QQLLQPGEDECDN---SSSGVSSEQEQLALAAGVTLPGGGKPTDTIKKKPSVT 1450
              .|        .|.|:....:.||   :||..:|....:.|.                 ||...
 Worm   989 DHSPNVQRVTLISQHLEDNYGQKDNMSVASSSTASSSSTVDLT-----------------KPGCF 1036

  Fly  1451 IVEE----PKTIPDQPSSNTSHTTKPMAKTTIS 1479
            :|..    |....|.|.|.|..:...:..:.||
 Worm  1037 VVPSHVIPPVDYDDDPDSGTGDSDGEIRCSEIS 1069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_f0 20..103 CDD:293120 45/80 (56%)
Ank_2 128..222 CDD:289560 43/93 (46%)
ANK 131..233 CDD:238125 49/102 (48%)
ANK repeat 157..189 CDD:293786 12/31 (39%)
ANK 186..312 CDD:238125 65/126 (52%)
ANK repeat 191..222 CDD:293786 18/30 (60%)
Ank_2 196..322 CDD:289560 67/126 (53%)
ANK repeat 224..289 CDD:293786 27/65 (42%)
ANK repeat 291..322 CDD:293786 22/30 (73%)
ANK repeat 324..353 CDD:293786 7/28 (25%)
SH3 532..586 CDD:302595 0/53 (0%)
PDZ_signaling 706..798 CDD:238492 44/91 (48%)
shn-1NP_001379494.1 FERM_F0_SHANK 8..91 CDD:340611 45/80 (56%)
PHA03095 116..>317 CDD:222980 98/201 (49%)
ANK repeat 145..176 CDD:293786 12/30 (40%)
ANK repeat 178..209 CDD:293786 18/30 (60%)
ANK repeat 211..277 CDD:293786 27/65 (42%)
ANK repeat 279..310 CDD:293786 22/30 (73%)
PDZ_signaling 435..526 CDD:238492 44/90 (49%)
SAM_Shank1,2,3 1074..1139 CDD:188905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160160162
Domainoid 1 1.000 85 1.000 Domainoid score I5254
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 406 1.000 Inparanoid score I1077
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001441
OrthoInspector 1 1.000 - - oto17406
orthoMCL 1 0.900 - - OOG6_103134
Panther 1 1.100 - - LDO PTHR24135
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3037
SonicParanoid 1 1.000 - - X750
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.010

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