DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prosap and Shank2

DIOPT Version :9

Sequence 1:	NP_610925.3	Gene:	Prosap / 50225	FlyBaseID:	FBgn0040752	Length:	1871	Species:	Drosophila melanogaster
Sequence 2:	XP_017444204.1	Gene:	Shank2 / 171093	RGDID:	628772	Length:	1853	Species:	Rattus norvegicus

Alignment Length:	2015	Identity:	522/2015 - (25%)
Similarity:	762/2015 - (37%)	Gaps:	696/2015 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKFLDEERR 84
            |::|:.:.:|...||::|..:..||..||::|.:|.:.||:..|||||.|.:||:.||||||||.
  Rat    57 LVIRVVIQDLQQTKCIRFNPDATVWVAKQRILCTLNQGLKDVLNYGLFQPASNGRDGKFLDEERL 121

  Fly    85 LGDYPFNGPVGY----LELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEKIAKMCA 145
            |.:||  .|:|.    ||.:||:||||...|||:||..|||:.||::|::......|||:.|:..
  Rat   122 LREYP--QPMGQGVPSLEFRYKKRVYKQSNLDEKQLARLHTKTNLKKFMDHTQHRSVEKLVKLLD 184

  Fly   146 KGLDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVST 210
            :|||||||..|:|:||||:|.......:::.||.||||.||:|::||.||||:|....:..|:.|
  Rat   185 RGLDPNFHDLETGETPLTLAAQLDGSMEVIKALRNGGAHLDFRSRDGMTALHKAARMRNQVALKT 249

  Fly   211 LLELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRHGLVQHL 275
            ||||||||:|:|..|:||||.:.....:....|.|||:||::..:|..||:|:|||||:|.||||
  Rat   250 LLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHASVCCKDENGWHEIHQACRYGHVQHL 314

  Fly   276 EHLLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVIAGNLEL 340
            ||||||||||..:|||||:.||:||:.||::|||:|||||..:..:|:.:|||:|||:||||.||
  Rat   315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGDKELKNYNSQTPFQVAIIAGNFEL 379

  Fly   341 AEIIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNGAANGNN 405
            ||.|:|:|..||||||..|.|:.:||.....|    ||...||.            ||...|.|.
  Rat   380 AEYIKNHKETDIVPFREAPAYSNRRRRPPNTL----AAPRVLLR------------SNSDNNLNA 428

  Fly   406 GAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPCPSEHML 470
            ||....:..:..:                  |::...||.||.           |..|..:...|
  Rat   429 GAPEWAVCSAATS------------------HRSLSPQLLQQT-----------PSKPDGATKSL 464

  Fly   471 GAYS----SASSSLSE----GSSGHRSHEDDISIVTDKSLGDTSDIIS--DSSGVGTNSDSAACS 525
            |:|:    |.|.||:.    |..|.|.......:.:..:.|...|.:|  :..|......||.
  Rat   465 GSYAPGPRSRSPSLNRLGGAGEDGKRPQPPHWHVGSPFTPGANKDSLSTFEYPGPRRKLYSAV-- 527

  Fly   526 IGHPSTTVVCMEPYAGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLR 590
               |....|.::||.....|.|.|..||.::|:...:.|..||..||  ..|:|||:||:||
  Rat   528 ---PGRLFVAIKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARG--HIGWFPAECVEEV--- 584

  Fly   591 QKHITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLS 655
                                    |..|..|.|.:           .:..|..|.:
  Rat   585 ------------------------QCKPRDSQAET-----------RADRSKKLFR--------- 605

  Fly   656 VASNGSCQQPLESNEGGASGNGINNRNNNHSVGQYSSATAPRIKKSAYNAPRSVVLHRA-KRGFG 719
                                        :::||.|.|..|   ........::|||.:. ..|||
  Rat   606 ----------------------------HYTVGSYDSFDA---ASDCIIEDKTVVLQKKDNEGFG 639

  Fly   720 FILRGAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVE 784
            |:||||||.:.:.:..|:..|||||||:.||.||||..||||.||||:.:|.|:|....|.|||.
  Rat   640 FVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVN 704

  Fly   785 MIRSAGALVNLTVVSPQFPHQMQASAQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPG 849
            |||..|..:.|.||                                         |:.|.:
  Rat   705 MIRQGGNHLVLKVV-----------------------------------------TVTRNL---- 724

  Fly   850 GSGPGSSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGLENGG---------EKEDDLPHTKS 905
              .|..::.   :.||.||:|.|.|.|::   |:|||.|.||..|         .|:.|.|.
  Rat   725 --DPDDTAR---KKAPPPPKRAPTTALTL---RSKSMTAELEELGLSLVDKASVRKKKDKPE--- 778

  Fly   906 NSVESIATPTPTGIQTGPGTPVQLRTASIKARPTSSRITAA-ELEELFQRQQGEGSAANASRYAT 969
               |.:....|:  :|.....::.|.|:||.||||....|| ::..:::||   |.|
  Rat   779 ---EIVPASKPS--RTAENVAIESRVATIKQRPTSRCFPAASDVNSVYERQ---GIA-------- 827

  Fly   970 MMTSSRFQSGTDSGAATPPASNGSPMRSGP---LVYGSVAEMKRKTARSKHGSGTLRGKPVATPT 1031
            :||               |...|||  .||   |..|::...|...:|......|...:....|.
  Rat   828 VMT---------------PTVPGSP--KGPFLGLPRGTMRRQKSIDSRIFLSGITEEERQFLAPP 875

  Fly  1032 VGPGGAGGGRDLK--RFHSTPDLHGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRLNSNQGE 1094
            :          ||  |..|.||                      :.:|:..
  Rat   876 M----------LKFTRSLSMPD----------------------TSEDIPP-------------- 894

  Fly  1095 LKLGGLGAGSATGAGGAVLPPPNHPPPPPPVGQVVKVETRSSVSEYESTI--SLQQ----KLKKR 1153
                               ||.:.||.|||.........||.......||  :..|    |:...
  Rat   895 -------------------PPQSVPPSPPPPSPTTYNCPRSPTPRVYGTIKPAFNQNPVAKVPPA 940

  Fly  1154 TENDAVTSA---------------AID---------GVQSSF---------NP------SANAKI 1179
            |.:|.|.:.               ::|         ..|::|         ||      .|:..:
  Rat   941 TRSDTVATMMREKGMFYRRELDRFSLDSEDVYSRSPAPQAAFRTKRGQMPENPYSEVGKIASKAV 1005

  Fly  1180 Y--ASPQELRNVMAWKLRQAQEKP--------------------SQETSAGSQQPVS-QYAAPTQ 1221
            |  |.|.. |..|..|....::.|                    |.::|.||...:. |...|.|
  Rat  1006 YVPAKPAR-RKGMLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQATEPGQ 1069

  Fly  1222 MRPAQQQQQAQQPPTALASHYAAPQVQVQQVQQVQQSP--------QQSAPQSPPAP-------- 1270
            :||......:.....|:|   .|.:.:.::::..:.||        .:.....||||
  Rat  1070 LRPDDSLTVSSPFAAAIA---GAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRMQPSKFP 1131

  Fly  1271 ----------------PLPQAAPVPAQN---GNGNGSTSGAGSAPPIPEPDYSCSESDGEDENSI 1316
                            |.|.|||...:|   |.|.....|....|.     .|.|::.|
  Rat  1132 EEGGFGDEDETEQPLLPTPGAAPRELENHFLGGGEAGAQGEAGGPL-----SSTSKAKG------ 1185

  Fly  1317 LVARNTKLNEKIALFDVPETSGNSQASGSSSNSGSASISHSLSVEEIQ-----------RIRSNL 1370
                             || ||.:.|..|||.:...:..|.|:...:.           |.|: :
  Rat  1186 -----------------PE-SGPAAALKSSSPASPENYVHPLTGRLLDPSSPLALALSARDRA-M 1231

  Fly  1371 KTSKSSPNGFAKKPEEEKP----------------------------QQEQQQSHQQPQQLLQPG 1407
            :.|:....|.|.|.:..||                            :||.:..::......:..
  Rat  1232 QESQQGHKGEAPKADLNKPLYIDTKMRPSVESGFPPVTRQNTRGPLRRQETENKYETDLSKDRRA 1296

  Fly  1408 EDECDNSSSGVSSEQEQ---LALAAGVTLPGGGKPT---------DTIKKKPSVTIVEEPKTIPD 1460
            :|:.:...:.|.:.|::   |.:...|.:|..|.|.         ||   ||.    ..|.|:|:
  Rat  1297 DDKKNMLINIVDTAQQKSAGLLMVHTVDIPVAGPPLEEEEDREDGDT---KPD----HSPSTVPE 1354

  Fly  1461 -----QPSSNTSHTTKPMA---KTTISIGGGGSAV---------PTATLTVKQ------------ 1496
                 :.:...|...:|.|   :|.::.|....||         |.|::.:.:
  Rat  1355 GVPKTEGALQISAAPEPAAAPGRTIVAAGSVEEAVILPFRIPPPPLASVDLDEDFLFTEPLPPPL 1419

  Fly  1497 ---------------------LVQQQHAPVIQQQQQQLGSKQPVTAASTNKFTQQSN-INSNVMS 1539
                                 ||:|:.:..  .|...|.|.||..:..:.|....|| :.|:.:.
  Rat  1420 EFANSFDIPDDRAASVPALADLVKQKKSDT--PQPPSLNSSQPANSTDSKKPAGISNCLPSSFLP 1482

  Fly  1540 P-------------QVLGRIPSHHHQQQSSNPNQKLIATQQQILQQQQQQLAHQQHLQQILKAKA 1591
            |             :|..|..|.||.:.:|.     |:|...|                   :..
  Rat  1483 PPESFDAVTDSGIEEVDSRSSSDHHLETTST-----ISTVSSI-------------------STL 1523

  Fly  1592 AAAGGAS-NTAVLVA----------------KHQQKLHKGTSSGHESEMETRSDLEDDDGDL--- 1636
            ::.||.| :|..:.|                |.:..:||..:...::..|     ||.||.:
  Rat  1524 SSEGGESMDTCTVYADGQAFVVDKPPVPPKPKMKPIVHKSNALYQDTLPE-----EDTDGFVIPP 1583

  Fly  1637 -SPSPP--------AKAFQRHNS-------------LTRKQAAAIA--------MQRG------- 1664
             :|.||        ||..|...|             |:..:|..|:        |.||
  Rat  1584 PAPPPPPGSAQAGVAKVIQPRTSKLWGDVTEVKSPILSGPKANVISELNSILQQMNRGKSVKPGE 1648

  Fly  1665 -------------------------ATRTTAVSLMQLPPPLEADSDGEPSQLTLQRQQSHHPSQT 1704
                                     .||:|.|:....|        |....:|||.:...:.|:|
  Rat  1649 GLELPVGAKSANLAPRSPEVMSTVSGTRSTTVTFTVRP--------GTSQPITLQSRPPDYESRT 1705

Fly 1705 1704
Rat 1706 1705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_f0	20..103	CDD:293120	38/86 (44%)
		Ank_2	128..222	CDD:289560	46/93 (49%)
		ANK	131..233	CDD:238125	51/101 (50%)
		ANK repeat	157..189	CDD:293786	14/31 (45%)
		ANK	186..312	CDD:238125	70/125 (56%)
		ANK repeat	191..222	CDD:293786	18/30 (60%)
		Ank_2	196..322	CDD:289560	69/125 (55%)
		ANK repeat	224..289	CDD:293786	35/64 (55%)
		ANK repeat	291..322	CDD:293786	17/30 (57%)
		ANK repeat	324..353	CDD:293786	18/28 (64%)
		SH3	532..586	CDD:302595	20/53 (38%)
		PDZ_signaling	706..798	CDD:238492	47/92 (51%)
Shank2	XP_017444204.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342315
Domainoid	1	1.000	54	1.000	Domainoid score	I10928
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1814
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001441
OrthoInspector	1	1.000	-	-		otm46280
orthoMCL	1	0.900	-	-		OOG6_103134
Panther	1	1.100	-	-	O	PTHR24135
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X750
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890