DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosap and cytip

DIOPT Version :9

Sequence 1:	NP_610925.3	Gene:	Prosap / 50225	FlyBaseID:	FBgn0040752	Length:	1871	Species:	Drosophila melanogaster
Sequence 2:	XP_003199223.2	Gene:	cytip / 100537036	ZFINID:	ZDB-GENE-140106-76	Length:	343	Species:	Danio rerio

Alignment Length:	306	Identity:	65/306 - (21%)
Similarity:	120/306 - (39%)	Gaps:	51/306 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 SCQQPLESNEGGASGNGINN----RNNNHSVGQYSSATAPRIKKSAYNAPRSVVL--HRAKRGFG 719
            |...|...|..|..|..::.    |.:::|:..|   |.|:         |::|:  .:....||
Zfish    38 SFSSPKNLNTEGMKGRTLSQSQLARTHSNSLVDY---TDPQ---------RTMVVLEKQDNEVFG 90

  Fly   720 FILRGAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVE 784
            |     :..:..::::.:.......::..|..|..|:.|||..||.:|::||..:..::|:.::|
Zfish    91 F-----EVQTYGLKVKNTSMVEMCTFVCRVQDGSAAETAGLTAGDIILSVNGVSIEGSTHQNIIE 150

  Fly   785 MIRSAGALVNLTVVSPQFPH--QMQASAQYLPSGAR----------AGSHHLNSGPSTPQSSHRQ 837
            :||.:...:.|..||.....  :::....||....|          .....|..|.....:.:..
Zfish   151 LIRESSNTLKLETVSGSVMKRIELEKKMHYLKQTLREKWVELQSLTLKEKRLTQGNLNESAQYLS 215

  Fly   838 CATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGLENGG-----EKE 897
            ..::....:..|.||...||..|.|........|.....||  ....|.::.:|:.|     |..
Zfish   216 VDSVMSLSSPMGRSGQRFSSDSSCRSIMTDDSEDGAFMSSV--FDDSSPLSPIESSGSFFQLEVG 278

  Fly   898 DDLPHTKSNSVE---SIATPTPTGIQTGP----GT-PVQLRTASIK 935
            ...|.|::.|:.   |.::.:| |.:|.|    || |.:.|..|::
Zfish   279 ALRPITRTRSISLTGSNSSLSP-GWETSPSSLFGTLPRRSRKGSVR 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_f0	20..103	CDD:293120
		Ank_2	128..222	CDD:289560
		ANK	131..233	CDD:238125
		ANK repeat	157..189	CDD:293786
		ANK	186..312	CDD:238125
		ANK repeat	191..222	CDD:293786
		Ank_2	196..322	CDD:289560
		ANK repeat	224..289	CDD:293786
		ANK repeat	291..322	CDD:293786
		ANK repeat	324..353	CDD:293786
		SH3	532..586	CDD:302595
		PDZ_signaling	706..798	CDD:238492	21/93 (23%)
cytip	XP_003199223.2	PDZ_signaling	78..162	CDD:238492	19/88 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910