DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prosap and grip2

DIOPT Version :9

Sequence 1:	NP_610925.3	Gene:	Prosap / 50225	FlyBaseID:	FBgn0040752	Length:	1871	Species:	Drosophila melanogaster
Sequence 2:	XP_031757025.1	Gene:	grip2 / 100495373	XenbaseID:	XB-GENE-854056	Length:	1115	Species:	Xenopus tropicalis

Alignment Length:	1286	Identity:	239/1286 - (18%)
Similarity:	390/1286 - (30%)	Gaps:	484/1286 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RVYKMLTLDERQLKALHTRANLRRFLECINGGHVEKIAKMCAKGLDPNFHCS----ESGDTPLTV 164
            ||.|:|.:..|..:. ..|.::|...:..:.|..|...:.|.:||     ||    .|.|.|  .
Frog     3 RVNKVLRIVRRPSRR-KKRESIRAEEDEDDDGDQESQEESCEEGL-----CSLSLCVSDDGP--Y 59

  Fly   165 ATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVSTLLELGASPNYRDGRGITPL 229
            :.|.|.|....:|||:                    ...|:.              .:.||:|
Frog    60 SKGNKDPAGNDLALVS--------------------RRQSIP--------------EEFRGVT-- 88

  Fly   230 YISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRHGLVQHLEHLLFYGADMDGRNASGNS 294
                       |.|.:..:.:|||:..|.                       |.|.||:....|
Frog    89 -----------IVELIKKEGSTLGLTISG-----------------------GTDKDGKPRVSN- 118

  Fly   295 PLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVIAGNL------ELAEIIENYKSEDI- 352
                             |..|......:..|...|..:|...||      |:..:::|.....:
Frog   119 -----------------LRSGGLAARSDQLNIGDYIKSVNGINLTKLRHEEIISLLKNVGERVVL 166

  Fly   353 -VPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNGAANGNNGAGGVGLMLSH 416
             |.:..||. .|...|.|...:..     ..|...|..||..|.|
Frog   167 EVEYELPPA-TPDNSSAIIPKTIE-----ITLCKEGNSFGFVMRG-------------------- 205

  Fly   417 QNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPCPSEHMLGAYSSASSSL- 480
                    |.|:..|               :..|.:.|..  .|..|...|..|    ..|..|
Frog   206 --------GAHEDWH---------------KSRPLVVTYV--RPGGPADREGTL----KVSDRLL 241

  Fly   481 -SEGSSGHR-SHEDDISIVT------------DKSLGDTSDIISDSSG------VGTNSDSAACS 525
             .:|.|.|. :|.|.:||:.            |.:|.||   ::::||      ..|...:...|
Frog   242 CVDGISLHNITHTDALSILRQCSQEAVFQIEYDVALMDT---VTNASGPLLVEIAKTPGSTLGIS 303

  Fly   526 IG---HPSTTVVCMEPYAGNTV----GHIRLQPGD-VIEVVG-STD-CGLLEGYVRGTNQSGFFP 580
            :.   |.:..|:.::.....:|    |  .|.||| ::.:.| ||: |.|:|        :....
Frog   304 LSTGTHRNKQVIVIDKVKPASVVDRCG--ALHPGDHILSIDGTSTEHCTLME--------ATQLL 358

  Fly   581 ADCVQEVSLR--QKHITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSST 643
            |..::.|.|.  ..|.:.:..........|:...|....|    ..:|..:|      |.|...|
Frog   359 ASIIENVKLEILPAHHSRLSLRPPETVKVQKSDHHHCWDP----CVNYCHTP------HPGHCKT 413

  Fly   644 LLQQPHQSPSLSVASNGS-CQQPLESNEGGAS--GN-GINNRNNN------HSVGQYSSATAPRI 698
                    |:.:..||.. |:..:.:|...:|  |. |.:::|:|      |.:...::.:..|.
Frog   414 --------PTWNSTSNQEYCKSLVAANFSSSSVAGTPGFSSQNSNTLPRTAHPMSPRTTMSRRRQ 470

  Fly   699 KKSAYNA----------PRSVVLHRAK----------RGFGFILRGAKASSQLMQLRPSERFPAL 743
            |:..:.:          |...::|...          .|||..|:|...:::.:...|..||
Frog   471 KRKDHKSSLSLASSTVGPGGQIIHTESTEIILRGDPLNGFGIQLQGGIFATETLSSPPLIRF--- 532

  Fly   744 QYLDDVDPGGVADMAG-LRPGDFLLTINGEDVTSASHEQVVEMIRSAGALVNLTVVSPQFPHQMQ 807
                 ::|...|:..| |:.||.||:|||......:.|:..:::|.| ||.|...:..:|    .
Frog   533 -----IEPDSPAERCGLLQVGDRLLSINGILTEDGTLEEANQLLRDA-ALSNKVALEIEF----D 587

  Fly   808 ASAQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSGPGSSSGGSVRMAPMPPRRDP 872
            .:...:||   :|:.|:.               ||::        .|...|.::..|...| .:|
Frog   588 VAESVVPS---SGTFHVK---------------LPKR--------KGVELGITISSASRKP-GEP 625

  Fly   873 KTTLSVGRARAKSMVAGLENGGE---------------------------------KEDDLPHTK 904
            .....:.:.........||.|.:                                 |::|....:
Frog   626 LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCSMEDAVQILRQCEDLVKLKIRKDEDNSDEQ 690

  Fly   905 SNSVESIATPT------PTGIQTG----PGTPV------------------------QLRTASIK 935
            ..|...|.|..      |.||...    |..|:                        .:...|:|
Frog   691 ETSGAIIYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHIGDRILAINNVSLK 755

  Fly   936 ARPTSSRITAAEL-------------EELFQRQ----QGEGS--------AANASR----YATMM 971
            .:|.|..|...::             |.:|.::    ..|||        :...|:    |:|.:
Frog   756 GKPLSEAIHLLQMAGETVTLKIKKQAERIFPQRLSDSMNEGSDPEDDLTDSQKTSKLSDIYSTAV 820

  Fly   972 TS------SRFQSGTDSG---------------------------AATPPASNGSPMRSGPLVYG 1003
            .|      |...||.|:|                           ::|||..:   .:|.|.:.|
Frog   821 PSVDSALESWDGSGIDAGYGSQGTYVPQAVGISLHPHEWRTSRQKSSTPPVEH---RKSYPFLDG 882

  Fly  1004 SVAEMKRKTARSKHGSGTLRGKPVATPTVGPGGAGGGRDLKRFHSTPDLHGPQLHGSASSIWQAS 1068
            |..|...:             ||...|: .|.|.....|                   .|.|:..
Frog   883 SFNEQDWE-------------KPTRYPS-QPNGLEADHD-------------------DSFWRVF 914

  Fly  1069 GKGHHSQDDVATLHASLQRLNSNQGELKLG---GLGAGSA------TGAGGAVL-PPPNHP--PP 1121
            |:   :.:|:.|...| :.|...:..:..|   |||..|:      :..||.|| ...:||  ..
Frog   915 GE---ALEDLETCGQS-ELLREIEASIMTGSVQGLGLDSSQILLENSNQGGHVLFRKGSHPISSN 975

  Fly  1122 PPPVGQVVKVETRSSVSEYESTISLQQKLKKRT-----ENDAVTSAAIDGV 1167
            .|.....:..|.|:...|.....||..:|.|.|     :.|....:..||:
Frog   976 SPKKENKLSQEARTKKEEVHDAQSLSTELLKVTVQKDMDTDDFGFSVSDGL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_f0	20..103	CDD:293120
		Ank_2	128..222	CDD:289560	17/97 (18%)
		ANK	131..233	CDD:238125	20/105 (19%)
		ANK repeat	157..189	CDD:293786	9/31 (29%)
		ANK	186..312	CDD:238125	15/125 (12%)
		ANK repeat	191..222	CDD:293786	1/30 (3%)
		Ank_2	196..322	CDD:289560	17/125 (14%)
		ANK repeat	224..289	CDD:293786	13/64 (20%)
		ANK repeat	291..322	CDD:293786	3/30 (10%)
		ANK repeat	324..353	CDD:293786	7/36 (19%)
		SH3	532..586	CDD:302595	14/60 (23%)
		PDZ_signaling	706..798	CDD:238492	27/102 (26%)
grip2	XP_031757025.1	PDZ_signaling	87..169	CDD:238492	21/135 (16%)
		PDZ_signaling	187..272	CDD:238492	24/138 (17%)
		PDZ_signaling	287..370	CDD:238492	19/92 (21%)
		PDZ_signaling	499..585	CDD:238492	25/94 (27%)
		PDZ_signaling	598..681	CDD:238492	11/106 (10%)
		PDZ_signaling	697..778	CDD:238492	12/80 (15%)
		PDZ_signaling	1007..1084	CDD:238492	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910