DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prosap and wdr19

DIOPT Version :9

Sequence 1:	NP_610925.3	Gene:	Prosap / 50225	FlyBaseID:	FBgn0040752	Length:	1871	Species:	Drosophila melanogaster
Sequence 2:	XP_031749755.1	Gene:	wdr19 / 100144725	XenbaseID:	XB-GENE-920013	Length:	1344	Species:	Xenopus tropicalis

Alignment Length:	358	Identity:	73/358 - (20%)
Similarity:	120/358 - (33%)	Gaps:	136/358 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 YLELKYKRRVYKML-------------TLDERQLKALH----------------------TRANL 125
            ::|:::..|||:.:             .:::..|.|.|                      ....:
Frog   688 HMEVEFAIRVYRTIGNVGMVMSLEQIKGIEDHNLLAGHLAMFAGDFNLAQDLYLASSSPAAALEM 752

  Fly   126 RRFLECINGGHVEKIAKMCAKGLDPN---FHCSE-------SGDTPLTVA------TGAKKPNKL 174
            ||.|:     |.:. |...||.|.||   |...|       :||....:|      ||..|..:.
Frog   753 RRDLQ-----HWDS-ALQLAKRLAPNQISFISKEYAMQLEFTGDYVNALAHYEKGITGDNKFQEH 811

  Fly   175 LIALVNGGALLDYRTKDGSTALHRAVEHDS----------LEAVSTLLELGASPNYRDGRGITPL 229
            ....:.|.|.:..|..|....:::|::|.|          ||::..|.|  |:..|..|:
Frog   812 DETCLAGVARMSIRMGDIRRGVNQALKHPSRSLKKDCGAILESMKQLTE--AAQLYEKGQ----- 869

  Fly   230 YI----SITRKCE--AKITESLLH--------------------DHATLGIQDSQGWNEVHQACR 268
            |.    |:..:|:  ||:.|.|.|                    ..|.|..::::.|:.|.:.
Frog   870 YFDKAASVYIRCKNWAKVGELLPHVSSPKIHLQYAKAKEADGKYKEAVLAYENAKDWDNVIRI-- 932

  Fly   269 HGLVQHLEHLLFYGADMDGRNASGNSPLHVCAV-------NNQEACARMLLFRGAQRGAQNF--- 323
                 .|:||              |:|.....:       ...:..||..|..|....|..|
Frog   933 -----SLDHL--------------NNPEKAVGIVKETQSLEGAKMVARFFLKLGDYGSAIQFLVL 978

  Fly   324 --ANQTPYQVAVIAGNLEL-AEII--ENYKSED 351
              .|...:|:|.....:|: |:||  ||..:||
Frog   979 SKCNDEAFQLAQQHNQMEIYADIIGSENTSTED 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_f0	20..103	CDD:293120	1/6 (17%)
		Ank_2	128..222	CDD:289560	29/119 (24%)
		ANK	131..233	CDD:238125	30/131 (23%)
		ANK repeat	157..189	CDD:293786	8/37 (22%)
		ANK	186..312	CDD:238125	31/168 (18%)
		ANK repeat	191..222	CDD:293786	10/40 (25%)
		Ank_2	196..322	CDD:289560	32/168 (19%)
		ANK repeat	224..289	CDD:293786	15/90 (17%)
		ANK repeat	291..322	CDD:293786	7/37 (19%)
		ANK repeat	324..353	CDD:293786	11/31 (35%)
		SH3	532..586	CDD:302595
		PDZ_signaling	706..798	CDD:238492
wdr19	XP_031749755.1	WD40	<19..345	CDD:225201
		WD40 repeat	23..52	CDD:293791
		WD40 repeat	57..93	CDD:293791
		WD40 repeat	101..135	CDD:293791
		WD40 repeat	142..168	CDD:293791
		WD40 repeat	236..271	CDD:293791
		WD40 repeat	278..300	CDD:293791
		WD40 repeat	322..359	CDD:293791
		WD40_3	508..564	CDD:406360
		TPR	856..1144	CDD:223533	39/184 (21%)
		Clathrin	<911..966	CDD:421262	12/75 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D468249at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010