DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prosap and shank2

DIOPT Version :9

Sequence 1:NP_610925.3 Gene:Prosap / 50225 FlyBaseID:FBgn0040752 Length:1871 Species:Drosophila melanogaster
Sequence 2:XP_031755591.1 Gene:shank2 / 100124731 XenbaseID:XB-GENE-984534 Length:1842 Species:Xenopus tropicalis


Alignment Length:2003 Identity:522/2003 - (26%)
Similarity:771/2003 - (38%) Gaps:578/2003 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKFLDEERR 84
            :::||.:|:|...||::|.....||..||::|.:|.:.||:..||||:.|.:||:.||||||||.
 Frog    60 MVIRIVIPDLQQTKCIRFNPHATVWVAKQRILCTLNQSLKDVLNYGLYQPFSNGREGKFLDEERL 124

  Fly    85 LGDY--PFNGPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEKIAKMCAKG 147
            |.:|  |.:..|..||.:||:|:||..:|||:|:..|||:.|||:|::.::...||||.||..:|
 Frog   125 LREYPQPMSRGVPSLEFRYKKRLYKQPSLDEKQIAKLHTKGNLRKFMDYVHHCSVEKICKMLDRG 189

  Fly   148 LDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVSTLL 212
            ||||:|..::|:.|||::.......:::.||.||||.||:|.|||.||||:|....:...:.|||
 Frog   190 LDPNYHDPDNGENPLTLSAQMDNAVEMIKALRNGGAHLDFRAKDGMTALHKAARAKNQSTLMTLL 254

  Fly   213 ELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRHGLVQHLEH 277
            ||||||:|:|.||:||||.:.....:....|.|||:||.:|.:|..||.|:|||||:|..|||||
 Frog   255 ELGASPDYKDSRGLTPLYHTAMVGGDPYCCELLLHEHAAVGCKDENGWQEIHQACRYGHFQHLEH 319

  Fly   278 LLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVIAGNLELAE 342
            ||||||.|..:|||||:.||:||:.||::|||:||||||.:..:|:.:|:|:|||:||||.||||
 Frog   320 LLFYGATMGAQNASGNTALHICALYNQDSCARVLLFRGANKEIKNYNSQSPFQVAIIAGNFELAE 384

  Fly   343 IIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNGAANGNN-- 405
            .|:|:|..||||||..|.|:.:||.....|    ||...||.:          .|:...|.||  
 Frog   385 FIKNHKESDIVPFREAPSYSHRRRGPQSTL----AAPRVLLRS----------NSDNNLNVNNLP 435

  Fly   406 --GAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPCPSEH 468
              .|....|                       |.....|.|||.|            .:|..:..
 Frog   436 EWSASSASL-----------------------HRSLSPQLLQQMQ------------NNPNGTVK 465

  Fly   469 MLGAYS----SASSSLSE-GSSGHRSHEDDISIVTDKSLGDTSDIISDSSGVGTNSDSAACSIGH 528
            .:|:|:    |.|.||:. |....|.....||...:|......|.    .|......||.     
 Frog   466 TIGSYAQVPRSRSPSLNRLGEDAKRQQHRHISPGANKESAPALDF----QGPKRKLYSAL----- 521

  Fly   529 PSTTVVCMEPYAGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKH 593
            |....:.::.|.....|.|.|..||.|.|:...:.|..||..||  ..|:|||:||:|:      
 Frog   522 PGRHFIVVKSYQPQGEGEIPLHKGDRIRVLSIGEGGFWEGNARG--HVGWFPAECVEEI------ 578

  Fly   594 ITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVAS 658
                                 |..|:       .|.|:.    .:..:..|.:            
 Frog   579 ---------------------QPKPS-------DGRPET----RTDRTKKLFR------------ 599

  Fly   659 NGSCQQPLESNEGGASGNGINNRNNNHSVGQYSSATAPRIKKSAYNAPRSVVLHRA-KRGFGFIL 722
                                     :::||.|.|..|   ........::|||.:. ..||||:|
 Frog   600 -------------------------HYTVGSYDSFDA---SSDCIIEEKTVVLQKKDNEGFGFVL 636

  Fly   723 RGAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIR 787
            |||||.:.:.:..|:..|||||||:.||..|||..||||.||||:.:|.|:|....|.|||.|||
 Frog   637 RGAKADTPIEEFNPTPAFPALQYLESVDEDGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIR 701

  Fly   788 SAGALVNLTVVSPQFPHQMQASAQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSG 852
            ..|..:.|.||                                         |:.|.:      .
 Frog   702 QGGNHLVLKVV-----------------------------------------TVTRNL------D 719

  Fly   853 PGSSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGLENGGEKEDDLPHTKSNSVESIATPTPT 917
            |..::.   :.||.||:|.|.|.||:   |:|||.:.||........:...|..:.:|  .|.|.
 Frog   720 PDDTAR---KKAPPPPKRAPTTALSL---RSKSMTSELEELAVDIASVRRRKDKAEDS--GPIPK 776

  Fly   918 GIQTGPGTPVQLRTASIKARPTSSRITAA-ELEELFQRQ-------------QG----------- 957
            .::......|..|.|::|.||||....|| :...::.||             ||           
 Frog   777 PLRPLDNAAVDSRIATVKQRPTSRCFPAATDTNSMYDRQGIAVIPPTAPGSHQGPFLGIPRGTMR 841

  Fly   958 -----------EGSAANASRYAT--MMTSSRFQSGTDSGAATP--------------PASNGSPM 995
                       .|......::..  |:..:|..|..|:....|              |:|..||.
 Frog   842 RQKSIDSRIPLSGITEEERQFLAPPMLKFTRSLSMPDASEDIPPPPATLPPSPPPPSPSSFNSPK 906

  Fly   996 RSGPLVYGSVAEMKRKTARSKHGSGTLRGKPVATPTVGPGGAGGGRDLKRFH---------STPD 1051
            ...|..||::.....:.:.:|..|..:|...|.|.         .||...|:         .:.:
 Frog   907 SPAPRGYGTIKPAFTQNSGTKSPSPAVRSDNVGTI---------ARDKSMFYRHEANRFSLDSEE 962

  Fly  1052 LHGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRLNSNQGELKLGG----LGAGSATGAGGAV 1112
            |:...:....:.|.:.|....:...:|.                |||.    :.|..|...|..|
 Frog   963 LYNASMANQQNFINKRSKMPENPYSEVG----------------KLGNKAVYVPAKPARRKGMLV 1011

  Fly  1113 -------LPPPNHPPPPPPVGQVVKVETRSSV------SEYESTISLQQKLKKRTENDAVT---- 1160
                   .|......|.|.:  ::|..:.||.      |..|:.:.:.:::.:...:|::.    
 Frog  1012 KQSNVEDSPEKTCSIPIPTI--IIKEPSTSSSGKSSQGSSMETDLQISEQVGQLRPDDSLNASSP 1074

  Fly  1161 -SAAIDGVQSSFNPSANAKIYASPQELRNVMAWKLRQAQEKPSQETSAGSQQPVSQYAAPTQMRP 1224
             :|||.|..........|:        ||..|:          ..|..|     .:...|   :|
 Frog  1075 FAAAIAGAVRDREKRLEAR--------RNSPAF----------LSTDLG-----DECVGP---KP 1113

  Fly  1225 AQQQQQAQQPPTAL------ASHYAAPQVQV---------QQVQQVQQSPQQSAPQSPPAPPLPQ 1274
            :.:.|.::.....:      ..|..||...|         .......|....:|..|....|...
 Frog  1114 SPRLQHSKSIDDGMFFNDEHTKHLMAPSSLVLPRGSSNAFTNNDSSHQGDVSNARMSKIKGPENN 1178

  Fly  1275 AAPVPAQNGNGNGSTSGAGSAPPIPEPDYSCSESDGEDENS----ILVARNTKLNEKIALFDVPE 1335
            |||..:.|.:||......|..               .|.||    .|.||:..|.::        
 Frog  1179 AAPAKSTNSSGNYMHPVTGKL---------------LDPNSPLALALAARDRALKDQ-------- 1220

  Fly  1336 TSGNSQASGSSSNSGSASISHSLSVEEIQRIRSNLKTSKS-------SPN--GFAKKPE------ 1385
                :|.|.|.::...|.::..|.::  .::||.|::|.|       .||  |..|:.|      
 Frog  1221 ----NQPSPSPTDPEKADLNKPLYID--TKLRSGLESSFSVATINANRPNQRGKLKRQETESKHD 1279

  Fly  1386 -----EEKPQQEQQQ--------SHQQPQQLLQP------------GEDE-------CDNSSSGV 1418
                 |||.|:|::.        |.|:...||..            .|.|       .:||::.|
 Frog  1280 LDSSKEEKRQEEKKNMLINIMDTSQQKTAGLLMVHTVDTTKADDALAESEEAEKGTPPENSNAPV 1344

  Fly  1419 SSEQEQLALAAGVTLPGG---GKPTDTIKKK-PSVTIVEEPKTIP-------------DQPSSNT 1466
            |..:|:|.    .:||..   |.|...:.|. .||..||||..:|             |:....|
 Frog  1345 SEPREELE----NSLPKANVLGTPAAPLNKAIVSVCSVEEPVILPFRIPPPPFASMDVDEDFIFT 1405

  Fly  1467 SHTTKPMA-KTTISIGGGGSAVPTATLTVKQLVQQQHAPVIQQQ------QQQLGSKQPVTAAST 1524
            .....|:. ..:..|....|.:|.||| ...|:|:::...:...      ...:.||:|  |..|
 Frog  1406 EPLPPPLEFANSFEIPEDASQMPPATL-ADLLIQRKNGAFLPPSFNPNVASNSIDSKRP--AVLT 1467

  Fly  1525 N----KFTQQSNINSNVMS---PQVLGRIPSHHHQQQSSNPNQKLIATQQQILQQQQQQLAHQQH 1582
            |    .|.|......||..   .:...|..|.||.:.:|.     |:|                 
 Frog  1468 NCLPTSFMQHPESFDNVTDSGIEEADSRSGSDHHLETTST-----IST----------------- 1510

  Fly  1583 LQQILKAKAAAAGGASNTAVLVAKHQQKLHKGTSSGHESEMETRSDLEDDDGDLSPSPPAKAFQR 1647
                          .|:.:.|           :|.|.|: ::|.:...|....|...||.....:
 Frog  1511 --------------VSSISTL-----------SSEGGEN-LDTCTVYADGQAFLVDKPPVPPKPK 1549

  Fly  1648 HNSLTRKQAAAIAMQRGATRTTAVSLMQLPPPLEADSDGEPSQLTLQRQQSHHPSQTH------- 1705
            ...:..|   :.|:.:.|.....:....:|||       .|..|.|..|    ||.|.       
 Frog  1550 VKPIINK---SNALYKDAVLEENLDNFPVPPP-------APPPLPLSIQ----PSMTKAGQQRTS 1600

  Fly  1706 --------------PHPH-QLQQQLQLQQQQQQQQQQQQPMAAHIVGM-LPSGQLVAVAS----G 1750
                          |.|. .:..:|....||..:::..:|..    |: .|:|...|..|    .
 Frog  1601 KLWGDNTEVKSPVMPSPKANVISELNSILQQMNREKATKPGE----GLDSPTGMKTANLSTRGTD 1661

  Fly  1751 AVAGVPGVGATAV----QQGNNNLQQLCTDNLVLAPPPQF-CDCNDAKHAPQP 1798
            |::.|.|..:|.|    :.|.|  |.:...|..    |:| ......:.||.|
 Frog  1662 ALSTVSGNRSTTVTFTIRPGAN--QPISLQNRT----PEFEGRVTGMRRAPSP 1708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ProsapNP_610925.3 FERM_f0 20..103 CDD:293120 37/84 (44%)
Ank_2 128..222 CDD:289560 44/93 (47%)
ANK 131..233 CDD:238125 50/101 (50%)
ANK repeat 157..189 CDD:293786 12/31 (39%)
ANK 186..312 CDD:238125 70/125 (56%)
ANK repeat 191..222 CDD:293786 17/30 (57%)
Ank_2 196..322 CDD:289560 69/125 (55%)
ANK repeat 224..289 CDD:293786 35/64 (55%)
ANK repeat 291..322 CDD:293786 18/30 (60%)
ANK repeat 324..353 CDD:293786 17/28 (61%)
SH3 532..586 CDD:302595 19/53 (36%)
PDZ_signaling 706..798 CDD:238492 46/92 (50%)
shank2XP_031755591.1 FERM_F0_SHANK2 58..145 CDD:340696 37/84 (44%)
ANKYR 166..368 CDD:223738 104/201 (52%)
ANK repeat 199..231 CDD:293786 12/31 (39%)
ANK repeat 233..264 CDD:293786 17/30 (57%)
ANK repeat 266..331 CDD:293786 35/64 (55%)
Ank_2 279..364 CDD:403870 49/84 (58%)
ANK repeat 333..364 CDD:293786 18/30 (60%)
SH3_Shank2 524..575 CDD:212916 17/52 (33%)
PDZ_signaling 619..712 CDD:238492 46/92 (50%)
SAM_Shank1,2,3 1775..1840 CDD:188905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11041
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001441
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24135
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3037
SonicParanoid 1 1.000 - - X750
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.130

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