Protein Alignment Prosap and shank2

DIOPT Version :10

• Sequence 1: NP_610925.3
• Gene: Prosap / 50225
• FlyBaseID: FBgn0040752
• Length: 1871
• Species: Drosophila melanogaster
• Sequence 2: XP_031755591.1
• Gene: shank2 / 100124731
• XenbaseID: XB-GENE-984534
• Length: 1842
• Species: Xenopus tropicalis
• Alignment Length: 2003
• Identity: 522/2003 - (26%)
• Similarity: 771/2003 - (38%)
• Gaps: 578/2003 - (28%)

  Fly    20 LLVRIHVPELNVYKCLQFPSERLVWDVKQQVLASLPKELKESFNYGLFAPPANGKAGKFLDEERR 84
            :::||.:|:|...||::|.....||..||::|.:|.:.||:..||||:.|.:||:.||||||||.
 Frog    60 MVIRIVIPDLQQTKCIRFNPHATVWVAKQRILCTLNQSLKDVLNYGLYQPFSNGREGKFLDEERL 124

  Fly    85 LGDY--PFNGPVGYLELKYKRRVYKMLTLDERQLKALHTRANLRRFLECINGGHVEKIAKMCAKG 147
            |.:|  |.:..|..||.:||:|:||..:|||:|:..|||:.|||:|::.::...||||.||..:|
 Frog   125 LREYPQPMSRGVPSLEFRYKKRLYKQPSLDEKQIAKLHTKGNLRKFMDYVHHCSVEKICKMLDRG 189

  Fly   148 LDPNFHCSESGDTPLTVATGAKKPNKLLIALVNGGALLDYRTKDGSTALHRAVEHDSLEAVSTLL 212
            ||||:|..::|:.|||::.......:::.||.||||.||:|.|||.||||:|....:...:.|||
 Frog   190 LDPNYHDPDNGENPLTLSAQMDNAVEMIKALRNGGAHLDFRAKDGMTALHKAARAKNQSTLMTLL 254

  Fly   213 ELGASPNYRDGRGITPLYISITRKCEAKITESLLHDHATLGIQDSQGWNEVHQACRHGLVQHLEH 277
            ||||||:|:|.||:||||.:.....:....|.|||:||.:|.:|..||.|:|||||:|..|||||
 Frog   255 ELGASPDYKDSRGLTPLYHTAMVGGDPYCCELLLHEHAAVGCKDENGWQEIHQACRYGHFQHLEH 319

  Fly   278 LLFYGADMDGRNASGNSPLHVCAVNNQEACARMLLFRGAQRGAQNFANQTPYQVAVIAGNLELAE 342
            ||||||.|..:|||||:.||:||:.||::|||:||||||.:..:|:.:|:|:|||:||||.||||
 Frog   320 LLFYGATMGAQNASGNTALHICALYNQDSCARVLLFRGANKEIKNYNSQSPFQVAIIAGNFELAE 384

  Fly   343 IIENYKSEDIVPFRGPPRYNPKRRSGIGWLSANGAAGAALLAAAGGGFGGAMVGSNGAANGNN-- 405
            .|:|:|..||||||..|.|:.:||.....|    ||...||.:          .|:...|.||
 Frog   385 FIKNHKESDIVPFREAPSYSHRRRGPQSTL----AAPRVLLRS----------NSDNNLNVNNLP 435

  Fly   406 --GAGGVGLMLSHQNHQQHHAGHHQQQHMHHQHHQNHHQQLQQQQLPHLHTLQLHGPPSPCPSEH 468
              .|....|                       |.....|.|||.|            .:|..:..
 Frog   436 EWSASSASL-----------------------HRSLSPQLLQQMQ------------NNPNGTVK 465

  Fly   469 MLGAYS----SASSSLSE-GSSGHRSHEDDISIVTDKSLGDTSDIISDSSGVGTNSDSAACSIGH 528
            .:|:|:    |.|.||:. |....|.....||...:|......|.    .|......||.
 Frog   466 TIGSYAQVPRSRSPSLNRLGEDAKRQQHRHISPGANKESAPALDF----QGPKRKLYSAL----- 521

  Fly   529 PSTTVVCMEPYAGNTVGHIRLQPGDVIEVVGSTDCGLLEGYVRGTNQSGFFPADCVQEVSLRQKH 593
            |....:.::.|.....|.|.|..||.|.|:...:.|..||..||  ..|:|||:||:|:
 Frog   522 PGRHFIVVKSYQPQGEGEIPLHKGDRIRVLSIGEGGFWEGNARG--HVGWFPAECVEEI------ 578

  Fly   594 ITNVMTASTGMAPQQQQQQHLQQAPAGSSAASYQGSPQLSLGGHSGSSSTLLQQPHQSPSLSVAS 658
                                 |..|:       .|.|:.    .:..:..|.:
 Frog   579 ---------------------QPKPS-------DGRPET----RTDRTKKLFR------------ 599

  Fly   659 NGSCQQPLESNEGGASGNGINNRNNNHSVGQYSSATAPRIKKSAYNAPRSVVLHRA-KRGFGFIL 722
                                     :::||.|.|..|   ........::|||.:. ..||||:|
 Frog   600 -------------------------HYTVGSYDSFDA---SSDCIIEEKTVVLQKKDNEGFGFVL 636

  Fly   723 RGAKASSQLMQLRPSERFPALQYLDDVDPGGVADMAGLRPGDFLLTINGEDVTSASHEQVVEMIR 787
            |||||.:.:.:..|:..|||||||:.||..|||..||||.||||:.:|.|:|....|.|||.|||
 Frog   637 RGAKADTPIEEFNPTPAFPALQYLESVDEDGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIR 701

  Fly   788 SAGALVNLTVVSPQFPHQMQASAQYLPSGARAGSHHLNSGPSTPQSSHRQCATLPRKMTGPGGSG 852
            ..|..:.|.||                                         |:.|.:      .
 Frog   702 QGGNHLVLKVV-----------------------------------------TVTRNL------D 719

  Fly   853 PGSSSGGSVRMAPMPPRRDPKTTLSVGRARAKSMVAGLENGGEKEDDLPHTKSNSVESIATPTPT 917
            |..::.   :.||.||:|.|.|.||:   |:|||.:.||........:...|..:.:|  .|.|.
 Frog   720 PDDTAR---KKAPPPPKRAPTTALSL---RSKSMTSELEELAVDIASVRRRKDKAEDS--GPIPK 776

  Fly   918 GIQTGPGTPVQLRTASIKARPTSSRITAA-ELEELFQRQ-------------QG----------- 957
            .::......|..|.|::|.||||....|| :...::.||             ||
 Frog   777 PLRPLDNAAVDSRIATVKQRPTSRCFPAATDTNSMYDRQGIAVIPPTAPGSHQGPFLGIPRGTMR 841

  Fly   958 -----------EGSAANASRYAT--MMTSSRFQSGTDSGAATP--------------PASNGSPM 995
                       .|......::..  |:..:|..|..|:....|              |:|..||.
 Frog   842 RQKSIDSRIPLSGITEEERQFLAPPMLKFTRSLSMPDASEDIPPPPATLPPSPPPPSPSSFNSPK 906

  Fly   996 RSGPLVYGSVAEMKRKTARSKHGSGTLRGKPVATPTVGPGGAGGGRDLKRFH---------STPD 1051
            ...|..||::.....:.:.:|..|..:|...|.|.         .||...|:         .:.:
 Frog   907 SPAPRGYGTIKPAFTQNSGTKSPSPAVRSDNVGTI---------ARDKSMFYRHEANRFSLDSEE 962

  Fly  1052 LHGPQLHGSASSIWQASGKGHHSQDDVATLHASLQRLNSNQGELKLGG----LGAGSATGAGGAV 1112
            |:...:....:.|.:.|....:...:|.                |||.    :.|..|...|..|
 Frog   963 LYNASMANQQNFINKRSKMPENPYSEVG----------------KLGNKAVYVPAKPARRKGMLV 1011

  Fly  1113 -------LPPPNHPPPPPPVGQVVKVETRSSV------SEYESTISLQQKLKKRTENDAVT---- 1160
                   .|......|.|.:  ::|..:.||.      |..|:.:.:.:::.:...:|::.
 Frog  1012 KQSNVEDSPEKTCSIPIPTI--IIKEPSTSSSGKSSQGSSMETDLQISEQVGQLRPDDSLNASSP 1074

  Fly  1161 -SAAIDGVQSSFNPSANAKIYASPQELRNVMAWKLRQAQEKPSQETSAGSQQPVSQYAAPTQMRP 1224
             :|||.|..........|:        ||..|:          ..|..|     .:...|   :|
 Frog  1075 FAAAIAGAVRDREKRLEAR--------RNSPAF----------LSTDLG-----DECVGP---KP 1113

  Fly  1225 AQQQQQAQQPPTAL------ASHYAAPQVQV---------QQVQQVQQSPQQSAPQSPPAPPLPQ 1274
            :.:.|.::.....:      ..|..||...|         .......|....:|..|....|...
 Frog  1114 SPRLQHSKSIDDGMFFNDEHTKHLMAPSSLVLPRGSSNAFTNNDSSHQGDVSNARMSKIKGPENN 1178

  Fly  1275 AAPVPAQNGNGNGSTSGAGSAPPIPEPDYSCSESDGEDENS----ILVARNTKLNEKIALFDVPE 1335
            |||..:.|.:||......|..               .|.||    .|.||:..|.::
 Frog  1179 AAPAKSTNSSGNYMHPVTGKL---------------LDPNSPLALALAARDRALKDQ-------- 1220

  Fly  1336 TSGNSQASGSSSNSGSASISHSLSVEEIQRIRSNLKTSKS-------SPN--GFAKKPE------ 1385
                :|.|.|.::...|.::..|.::  .::||.|::|.|       .||  |..|:.|
 Frog  1221 ----NQPSPSPTDPEKADLNKPLYID--TKLRSGLESSFSVATINANRPNQRGKLKRQETESKHD 1279

  Fly  1386 -----EEKPQQEQQQ--------SHQQPQQLLQP------------GEDE-------CDNSSSGV 1418
                 |||.|:|::.        |.|:...||..            .|.|       .:||::.|
 Frog  1280 LDSSKEEKRQEEKKNMLINIMDTSQQKTAGLLMVHTVDTTKADDALAESEEAEKGTPPENSNAPV 1344

  Fly  1419 SSEQEQLALAAGVTLPGG---GKPTDTIKKK-PSVTIVEEPKTIP-------------DQPSSNT 1466
            |..:|:|.    .:||..   |.|...:.|. .||..||||..:|             |:....|
 Frog  1345 SEPREELE----NSLPKANVLGTPAAPLNKAIVSVCSVEEPVILPFRIPPPPFASMDVDEDFIFT 1405

  Fly  1467 SHTTKPMA-KTTISIGGGGSAVPTATLTVKQLVQQQHAPVIQQQ------QQQLGSKQPVTAAST 1524
            .....|:. ..:..|....|.:|.||| ...|:|:::...:...      ...:.||:|  |..|
 Frog  1406 EPLPPPLEFANSFEIPEDASQMPPATL-ADLLIQRKNGAFLPPSFNPNVASNSIDSKRP--AVLT 1467

  Fly  1525 N----KFTQQSNINSNVMS---PQVLGRIPSHHHQQQSSNPNQKLIATQQQILQQQQQQLAHQQH 1582
            |    .|.|......||..   .:...|..|.||.:.:|.     |:|
 Frog  1468 NCLPTSFMQHPESFDNVTDSGIEEADSRSGSDHHLETTST-----IST----------------- 1510

  Fly  1583 LQQILKAKAAAAGGASNTAVLVAKHQQKLHKGTSSGHESEMETRSDLEDDDGDLSPSPPAKAFQR 1647
                          .|:.:.|           :|.|.|: ::|.:...|....|...||.....:
 Frog  1511 --------------VSSISTL-----------SSEGGEN-LDTCTVYADGQAFLVDKPPVPPKPK 1549

  Fly  1648 HNSLTRKQAAAIAMQRGATRTTAVSLMQLPPPLEADSDGEPSQLTLQRQQSHHPSQTH------- 1705
            ...:..|   :.|:.:.|.....:....:|||       .|..|.|..|    ||.|.
 Frog  1550 VKPIINK---SNALYKDAVLEENLDNFPVPPP-------APPPLPLSIQ----PSMTKAGQQRTS 1600

  Fly  1706 --------------PHPH-QLQQQLQLQQQQQQQQQQQQPMAAHIVGM-LPSGQLVAVAS----G 1750
                          |.|. .:..:|....||..:::..:|..    |: .|:|...|..|    .
 Frog  1601 KLWGDNTEVKSPVMPSPKANVISELNSILQQMNREKATKPGE----GLDSPTGMKTANLSTRGTD 1661

  Fly  1751 AVAGVPGVGATAV----QQGNNNLQQLCTDNLVLAPPPQF-CDCNDAKHAPQP 1798
            |::.|.|..:|.|    :.|.|  |.:...|..    |:| ......:.||.|
 Frog  1662 ALSTVSGNRSTTVTFTIRPGAN--QPISLQNRT----PEFEGRVTGMRRAPSP 1708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prosap	NP_610925.3	FERM_F0_SHANK	20..103	CDD:340611	37/84 (44%)
		ANKYR	109..348	CDD:440430	126/238 (53%)
		ANK repeat	157..189	CDD:293786	12/31 (39%)
		ANK repeat	191..222	CDD:293786	17/30 (57%)
		ANK repeat	224..289	CDD:293786	35/64 (55%)
		ANK repeat	291..322	CDD:293786	18/30 (60%)
		ANK repeat	324..353	CDD:293786	17/28 (61%)
		SH3	532..586	CDD:473055	19/53 (36%)
		PDZ_SHANK1_3-like	703..800	CDD:467228	48/97 (49%)
shank2	XP_031755591.1	FERM_F0_SHANK2	58..145	CDD:340696	37/84 (44%)
		ANKYR	184..391	CDD:440430	111/206 (54%)
		ANK repeat	199..231	CDD:293786	12/31 (39%)
		ANK repeat	233..264	CDD:293786	17/30 (57%)
		ANK repeat	266..331	CDD:293786	35/64 (55%)
		ANK repeat	333..364	CDD:293786	18/30 (60%)
		SH3_Shank2	524..575	CDD:212916	17/52 (33%)
		PDZ_SHANK1_3-like	614..715	CDD:467228	49/141 (35%)
		Atrophin-1	1611..>1775	CDD:460830	25/108 (23%)
		SAM_Shank1,2,3	1775..1840	CDD:188905