DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OVOL1 and trem

DIOPT Version :9

Sequence 1:NP_004552.2 Gene:OVOL1 / 5017 HGNCID:8525 Length:267 Species:Homo sapiens
Sequence 2:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster


Alignment Length:251 Identity:74/251 - (29%)
Similarity:92/251 - (36%) Gaps:67/251 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    22 LPDE-ERGEIYVPVSLGFCPPQPYREPE-------PSVA-------------EPPSCPLALNMSL 65
            :|:| |..|.|.          .|.|.|       |.:|             |||...:|.::..
  Fly   168 VPNEIEEAETYA----------EYEEYELLTNENSPEIAQEKGSTGTDVATEEPPEEEIAEDILD 222

Human    66 RDSSYS---MAPGPC------VVAQLPSEDMGHLTDPQSRDHGFLRTKMKVTLGDSPSGDLFT-- 119
            .|..|.   ..|..|      .||.       |...|:..       ..|..:|..|...|.|  
  Fly   223 SDEDYDPTHAKPEKCDRSGRKPVAY-------HKNSPKVE-------TFKKKVGRKPRNKLSTYI 273

Human   120 CRVCQKAFTYQRMLNRHMKCHNDVKRHLCTYCGKGFNDTFDLKRHVRTHTGVRPYKCSLCDKAFT 184
            |.||...:..|..|..|||.|:.||.|.|..||:||.....|.||:.||||.|||||:.|..||.
  Fly   274 CDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFA 338

Human   185 QRCSLESHLKKIHGVQQKYAYKERRAKLYVCEECGCTSESQEGHVLHLKEHHPDSP 240
            .|.:...| .:||       .|||.   |||:.|..|....:....|...|..:.|
  Fly   339 DRSTKTKH-HRIH-------TKERP---YVCDVCSRTFTYSDNLKFHKMIHTGEKP 383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OVOL1NP_004552.2 C2H2 Zn finger 120..140 CDD:275368 8/19 (42%)
C2H2 Zn finger 148..168 CDD:275368 8/19 (42%)
zf-H2C2_2 160..185 CDD:316026 15/24 (63%)
C2H2 Zn finger 176..197 CDD:275368 6/20 (30%)
tremNP_650861.1 zf-AD 11..87 CDD:214871
COG5048 <264..411 CDD:227381 50/131 (38%)
C2H2 Zn finger 274..294 CDD:275368 8/19 (42%)
zf-H2C2_2 287..311 CDD:290200 13/23 (57%)
C2H2 Zn finger 302..322 CDD:275368 8/19 (42%)
zf-H2C2_2 315..338 CDD:290200 14/22 (64%)
C2H2 Zn finger 330..350 CDD:275368 6/20 (30%)
zf-H2C2_2 345..367 CDD:290200 11/32 (34%)
C2H2 Zn finger 358..378 CDD:275368 4/19 (21%)
zf-H2C2_2 370..394 CDD:290200 3/14 (21%)
C2H2 Zn finger 386..406 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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