Protein Alignment OTX2 and Ptx1

DIOPT Version :10

• Sequence 1: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Sequence 2: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Alignment Length: 245
• Identity: 80/245 - (32%)
• Similarity: 108/245 - (44%)
• Gaps: 55/245 - (22%)

Human    44 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQ 108
            ::|||:||.||..||..||..|::.||||:..|||:|:..||.|:||:|||||||||.|::::..
  Fly   262 KRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNA 326

Human   109 QNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIW----SPASISPLS 169
            .|..   |..|..|          ||...||..|.:..   ...||.|.:.|    ||....|..
  Fly   327 MNAA---VAAADFK----------SGFGTQFMQPFADD---SLYSSYPYNNWTKVPSPLGTKPFP 375

Human   170 DPLSTSSSCM-----QRSYPMTYTQASGYS---------QGYAGS----TSYFG--GMDCGSYLT 214
            .|::...|.:     |.|.....|.|||.:         .|..||    ||..|  |..| .|.|
  Fly   376 WPVNPLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNVGAVGAPC-PYTT 439

Human   215 P----MHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNS 260
            |    |:.....|          .::|.::.|.|:|..:....:|.||.|
  Fly   440 PANPYMYRSAAEP----------CMSSSMSSSIATLRLKAKQHASAGFGS 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	33/54 (61%)
		TF_Otx	161..242	CDD:427350	25/104 (24%)
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	33/55 (60%)