Protein Alignment OTX2 and eyg

DIOPT Version :10

• Sequence 1: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Sequence 2: NP_524042.2
• Gene: eyg / 39419
• FlyBaseID: FBgn0000625
• Length: 670
• Species: Drosophila melanogaster
• Alignment Length: 316
• Identity: 80/316 - (25%)
• Similarity: 119/316 - (37%)
• Gaps: 94/316 - (29%)

Human     8 PPYAVNGLSLTTSG-MDLLHPSVGYPGPWASCPAATP---------------------------R 44
            ||.|.:.:.::|.| :...|...|..|...:..|.:|                           .
  Fly   282 PPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENRHIDSDYLDDDDEP 346

Human    45 KQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQ 109
            |.||.||||:..||:.||..|.|:.||.:..||.::.:.:|.|:||||||.|||||.|:.|:
  Fly   347 KFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWRRHQR--- 408

Human   110 NGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVP---TIASSSAPVSIWSPAS------- 164
               .|.::  ::::|||..:.|:.....    |:|:..|   :.||:||||:...|..
  Fly   409 ---MNLLK--RQRSSPANPLHSQQSNDA----PASSPTPSNHSSASTSAPVAPVPPPQQPLPLCG 464

Human   165 ------------ISPLSDP-----------LSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGG 206
                        :.||..|           |.|..:.:|........|.....|.:.....
  Fly   465 DHSPQGPPPSVLLHPLHGPPGGHHHHHPLHLPTHPAALQLLSHYHQQQQQQQQQQHQQQQQ---- 525

Human   207 MDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSP-----ASLSTQGYGASSLG 257
                     .|||   ....|||.|.|...:||:...     .||.:....|:.||
  Fly   526 ---------QHHQ---QQQQLSPSGCNPAANHLSMGGERSAFRSLVSSPSAAAFLG 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	29/54 (54%)
		TF_Otx	161..242	CDD:427350	19/110 (17%)
eyg	NP_524042.2	HTH_ARSR	120..217	CDD:481197
		Homeodomain	349..405	CDD:459649	29/55 (53%)